Results 31 to 40 of about 493,813 (294)

99mTc-GSA scintigraphy for assessing the functional volume ratio of the future liver remnant in the routine practice of liver resection

Surgery Open Science, 2022
Background: The significance of incorporating regional functional heterogeneity assessment by liver scintigraphy into the calculation of the future liver remnant has been reported.
Masatake Iida, MD, PhD, Yuzo Yamamoto, MD, PhD, Hiroki Katoh, BHSc, Naoto Taniguchi, BHSc, Yuki Abe, MD, PhD, Kenta Kumagai, MD, Hiroshi Uchinami, MD, PhD   +6 more
doaj  

Binding of 99mTc to human serum albumin

Al-Mustansiriyah Journal of Pharmaceutical Sciences, 2004
The specificity of 99m Tc-MDP binding to HSA was examined , the results showed that the non specific binding was 21-23% of the total binding . The range of optimum pH for the binding was 7.4-7.6 .
Abdulrahman K. Loay
doaj   +1 more source

AlbuCORE: an albumin-based molecular scaffold for multivalent biologics design

mAbs, 2020
As biologics have become a mainstay in the development of novel therapies, protein engineering tools to expand on their structural advantages, namely specificity, affinity, and valency are of interest.
Mario Sanches, Igor D’Angelo, Maria Jaramillo, Jason Baardsnes, John Zwaagstra, Joe Schrag, Ian Schoenhofen, Mauro Acchione, Sam Lawn, Grant Wickman, Nina Weisser, David K. Y. Poon, Gordon Ng, Surjit Dixit   +13 more
doaj   +1 more source

Serum Albumin Redox States: More Than Oxidative Stress Biomarker

Antioxidants, 2021
Serum albumin is the most abundant circulating protein in mammals including humans. It has three isoforms according to the redox state of the free cysteine residue at position 34, named as mercaptalbumin (reduced albumin), non-mercaptalbumin-1 and -2 ...
Fuka Tabata, Yasuaki Wada, Satomi Kawakami, Kazuhiro Miyaji   +3 more
doaj   +1 more source

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

FEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp, Katharina Rataj, Stefanie König, Marcia E. Newcomer, Oliver Werz, Ulrike Garscha   +5 more
wiley   +1 more source

Recent Advancements in Serum Albumin-Based Nanovehicles Toward Potential Cancer Diagnosis and Therapy

Frontiers in Chemistry, 2021
Recently, drug delivery vehicles based on nanotechnology have significantly attracted the attention of researchers in the field of nanomedicine since they can achieve ideal drug release and biodistribution.
Xue Shen, Xiyang Liu, Tingting Li, Yin Chen, Yang Chen, Pan Wang, Lin Zheng, Hong Yang, Chunhui Wu, Shengqi Deng, Yiyao Liu, Yiyao Liu   +11 more
doaj   +1 more source

Circulating histones as clinical biomarkers in critically ill conditions

FEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez, Juan Carlos Ruiz‐Rodríguez, Ricard Ferrer, Raquel Durá, Antonio Artigas, Iván Bajaña, David Bolado López de Andujar, Irene Cánovas‐Cervera, Adrián Ceccato, Luis Chiscano‐Camón, Elena Climent‐Martinez, Georgia García Fernández, Gemma Goma, Verónica Monforte, Beatriz Quevedo‐Sánchez, Adolf Ruiz‐Sanmartín, Antonio Sierra‐Rivera, Nieves Carbonell Monleón   +17 more
wiley   +1 more source

A simple colorimetric assay to determine the concentration and proportion of human mercaptalbumin

Practical Laboratory Medicine, 2022
Objectives: Human serum albumin can take on two forms, mercaptalbumin (HMA) or non-mercaptalbumin (HNA), depending on the redox status of its Cys34. The ratio of HMA and HNA is considered to be a novel biomarker of oxidative stress.
Sawaki Tada, Keiko Yasukawa, Yutaka Yatomi, Tomoaki Uchiki   +3 more
doaj  

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

Molecular Oncology, EarlyView.
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park, Jae Won Oh, Hyewon Chung, Jung Won Kwon, Yi Rang Na, Kwang Pyo Kim, Seung Hyeok Seok   +6 more
wiley   +1 more source

THE EMULSIFICATION OF HUMAN SERUM ALBUMIN AND HYALURONIC ACID SOLUTIONS IN POLYDIMETHYLSILOXANE PDMS-1000 [PDF]

Biotechnologia Acta, 2014
To create a biologically inert material suitable for use in a wide range of temperatures and in corrosive environments, the methods of optical microscopy and NMR-cryometry were used for investigation of emulsification of solutions of human serum albumin ...
А. M. Ruban, A. I. Kazanets, T. V. Krupskaya, V. V. Turov   +3 more
doaj   +1 more source