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Telomerase activity reconstituted in vitro with purified human telomerase reverse transcriptase and human telomerase RNA component

Telomerase activity reconstituted in vitro with purified human telomerase reverse transcriptase and human telomerase RNA component
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Expression of Human Telomerase Reverse Transcriptase in Lymphangioleiomyomatosis

American Journal of Respiratory and Critical Care Medicine, 2002
Telomerase synthesizes nucleotide hexameric repeats (telomeres) at the ends of chromosomes, replacing base sequences that are lost from these sites during each mitotic cycle and protecting these ends against the action of exonucleases and ligases. Therefore, telomerase is essential for maintaining cellular replication.
Fumiyuki, Kumaki, Kazuyo, Takeda, Zu-Xi, Yu, Joel, Moss, Victor J, Ferrans   +4 more
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Butylidenephthalide Suppresses Human Telomerase Reverse Transcriptase (TERT) in Human Glioblastomas

Annals of Surgical Oncology, 2011
Telomerase is widely expressed in most human cancers, but is almost undetectable in normal somatic cells and is therefore a potential drug target. Using the human telomerase promoter platform, the naturally occurring compound butylidenephthalide (BP) was selected for subsequent investigation of antitumor activity in vitro and in vivo.We treated human ...
Po-Cheng, Lin, Shinn-Zong, Lin, Yi-Lin, Chen, Jeng-Shou, Chang, Li-Ing, Ho, Po-Yen, Liu, Li-Fu, Chang, Yeu-Chern, Harn, Shee-Ping, Chen, Li-Yi, Sun, Pi-Chun, Huang, Jung-Ting, Chein, Chang-Hai, Tsai, Chii-Wen, Chou, Horng-Jyh, Harn, Tzyy-Wen, Chiou   +15 more
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Immortalization of human osteoblasts by transferring human telomerase reverse transcriptase gene

Biochemical and Biophysical Research Communications, 2004
In the current study, in order to establish an immortalized osteoblast cell line, human mesenchymal stem cells (hMSCs) had been inducted into osteoblasts directionally by an osteo-inductive conditioned medium, then the osteoblasts were steadily transduced by a retroviral vector containing human telomerase reverse transcriptase (hTERT) gene.
Yin, Xiaoxue, Chen, Zhongqiang, Guo, Zhaoqing, Dang, Gengting, Ma, Qingjun, Wang, Shenwu   +5 more
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Telomerase activity and expression of human telomerase RNA component and human telomerase reverse transcriptase in lung carcinomas

Human Pathology, 2001
The aim of this study was to evaluate the usefulness of determination of telomerase activity and expression of human telomerase RNA component (hTERC) and human telomerase reverse transcriptase (hTERT) for the diagnosis of lung carcinomas. The tissues studied consisted of 115 carcinomas and adjacent nonneoplastic lung, which were removed surgically ...
F, Kumaki, T, Kawai, S, Hiroi, N, Shinomiya, Y, Ozeki, V J, Ferrans, C, Torikata   +6 more
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Activation of telomerase and expression of human telomerase reverse transcriptase in coronary atherosclerosis

Cardiovascular Pathology, 2005
Considerable research on telomerase on human neoplastic and normal long-lived proliferative tissues has emerged. We explored the expression of telomerase in atherosclerotic human epicardial coronary arteries.Forty discrete human coronary arterial segments obtained from 19 heart transplant recipients were classified into nonatherosclerotic and ...
Shih-Chi, Liu, Shoei-Shen, Wang, Mu-Zon, Wu, Deng-Chyang, Wu, Fang-Jung, Yu, Wen-Jone, Chen, Fu-Tien, Chiang, Meng-Fen, Yu   +7 more
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The significance of human telomerase reverse transcriptase (hTERT) in cancer

European Journal of Surgical Oncology (EJSO), 2001
Since the discovery of the enzyme telomerase in humans, it has become apparent that it is the most general of tumour markers known, and enormously significant in its potential for diagnostic, prognostic and therapeutic applications. Extensive work has identified three core components of the enzyme, of which the catalytic subunit hTERT (human telomerase
K L, Kirkpatrick, K, Mokbel
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Quantitative Analysis of Human Telomerase Reverse Transcriptase in Pancreatic Cancer

Clinical Cancer Research, 2006
Abstract Although telomerase activity is a promising diagnostic marker, clinical introduction of this marker for cancer diagnosis is still problematic due to the lack of means of evaluating sample quality. Human telomerase reverse transcriptase (hTERT), one of the subunits of telomerase, is also a promising diagnostic marker.
Kenoki, Ohuchida, Kazuhiro, Mizumoto, Daisuke, Yamada, Hiroshi, Yamaguchi, Hiroyuki, Konomi, Eishi, Nagai, Koji, Yamaguchi, Masazumi, Tsuneyoshi, Masao, Tanaka   +8 more
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Human Telomerase Reverse Transcriptase (hTERT) Positively Regulates 26S Proteasome Activity

Journal of Cellular Physiology, 2017
Human telomerase reverse transcriptase (hTERT) is the catalytic subunit of telomerase, an RNA‐dependent DNA polymerase that elongates telomeric DNA. hTERT displays several extra‐telomeric functions that are independent of its telomere‐regulatory function, including tumor progression, and neuronal cell death regulation. In this study, we evaluated these
Eunju, Im, Jong Bok, Yoon, Han-Woong, Lee, Kwang Chul, Chung   +3 more
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Detection of telomerase activity, telomerase RNA component, and telomerase reverse transcriptase in human hepatocellular carcinoma

Hepatology Research, 2004
The aim of this study was to estimate the correlation between telomerase activity and the expression of human telomerase RNA component (hTERC), human telomerase reverse transcriptase (hTERT) in patients with hepatocellular carcinoma (HCC), and to analyze the influence of the nucleotide homology of the hTERC template region on telomerase activity.
Masaki, Shimojima, Fumihiko, Komine, Hisashi, Hisatomi, Toshihiro, Shimizu, Mitsuhiko, Moriyama, Yasuyuki, Arakawa   +5 more
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