Results 211 to 220 of about 40,478 (236)

Prognostic Significance of Telomerase Activity and Human Telomerase Reverse Transcriptase Expression in Ampullary Carcinoma

Annals of Surgical Oncology, 2012
Telomerase activity and human telomerase reverse transcriptase (TERT) have been reported as markers of tumor aggressiveness and poor prognosis in several digestive cancers. In the present study, we examined telomerase activity and TERT expression in ampullary carcinoma to determine whether these parameters could be used as indicators of aggressiveness ...
Ryutaro, Sakabe, Yoshiaki, Murakami, Kenichiro, Uemura, Takeshi, Sudo, Yasushi, Hashimoto, Naru, Kondo, Akira, Nakashima, Hiroki, Ohge, Taijiro, Sueda, Eiso, Hiyama   +9 more
openaire   +2 more sources

Expression of Human Telomerase Reverse Transcriptase in Laryngeal Tissues

Otolaryngology–Head and Neck Surgery, 2004
ProblemTelomerase is believed to play a major role in transforming cells (immortalization) to carcinoma. Its activity has been detected in 90% of human cancers. We evaluated telomerase activity in laryngeal carcinoma patients who underwent surgery for cure through the immunohistochemical detection of human telomerase reverse transcriptase (hTERT ...
Ramon A Franco, Yongyuth Wasinwong
openaire   +1 more source

MCPH1/BRIT1 represses transcription of the human telomerase reverse transcriptase gene

Gene, 2012
MCPH1, a repressor of human telomerase reverse transcriptase (hTERT) function, is implicated in cellular immortalization. But little is known about how MCPH1 represses telomerase activity. In this study, to determine the mechanism by which MCPH1 regulates hTERT gene expression, we examined the role of MCPH1 in regulating the hTERT promoter in vitro. Co-
Lei, Shi, Ming, Li, Bing, Su
openaire   +2 more sources

Immunoprecipitation of Human Telomerase Reverse Transcriptase with Telomerase Activity

Analytical Biochemistry, 2001
J M, Kraveka, D, Schady, L M, Obeid, B, Ogretmen   +3 more
openaire   +2 more sources

Human telomerase reverse transcriptase and telomeres in cancer

Journal of Current Oncology, 2021
Anurag Mehta, Shrinidhi Nathany
openaire   +1 more source

Significance of immunological detection of human telomerase reverse transcriptase: re-evaluation of expression and localization of human telomerase reverse transcriptase.

The American journal of pathology, 2003
Human telomerase reverse transcriptase (hTERT) is a catalytic subunit of telomerase and is a potentially useful diagnostic marker for cancers. There have been few studies in which immunological detection of hTERT has been attempted and its subcellular localization has not been precisely defined.
Satoru, Kyo, Kenkichi, Masutomi, Yoshiko, Maida, Taro, Kanaya, Noriyuki, Yatabe, Mitsuhiro, Nakamura, Masaaki, Tanaka, Mitsuko, Takarada, Isamu, Sugawara, Seishi, Murakami, Takahiro, Taira, Masaki, Inoue   +11 more
openaire   +1 more source

Regulation of human telomerase in homeostasis and disease

Nature Reviews Molecular Cell Biology, 2020
Steven E Artandi
exaly  

M2 Anti-Human Telomerase Reverse Transcriptase

Hybridoma and Hybridomics, 2002
openaire   +1 more source

Detection of telomerase activity, human telomerase RNA, and telomerase reverse transcriptase in human hepatocellular carcinoma

Gastroenterology, 2000
Masaki Shimojima, Fumihiko Komine, Hiroshi Aoki, Toshihiro Shimizu, Tamiko Kaneko, Miki Kaneko, Mitsuhiko Moriyama, Yasuyuki Arakawa   +7 more
openaire   +1 more source

A second chance for telomerase reverse transcriptase in anticancer immunotherapy

Nature Reviews Clinical Oncology, 2016
Maurizio Zanetti
exaly