Cell Proliferation, EarlyView.Proteomics and functional validation reveal ITGA5 as a dual promoter of epithelial‐mesenchymal transition and anoikis resistance in human bronchial epithelium: targeting ITGA5 represents a novel therapeutic strategy for asthma airway remodelling. ABSTRACT Airway remodelling is a major contributor to persistent airflow limitation and irreversible lung ...
Ting Wang +10 more
wiley +1 more source
Effects of allopurinol and febuxostat on uric acid transport and transporter expression in human umbilical vein endothelial cells. [PDF]
PLoS Onevan der Pol KH +13 more
europepmc +1 more source
Cell Proliferation, EarlyView.Neurological disorders are hard to treat. Stem cell‐derived neural organoids enable research, and their transplantation aids CNS therapy, with this article reviewing relevant advances, challenges and prospects. ABSTRACT Neurological disorders are often devastating and notoriously difficult to repair, creating an urgent need for novel research models ...
Yutong Wang +8 more
wiley +1 more source
Bupleuri Radix Ameliorates Vascular Inflammation in Human Umbilical Vein Endothelial Cells via Modulation of Tight Junction Protein Expression and Inhibition of Nuclear Factor-κB Activation. [PDF]
J PharmacopunctureKim MY, Bang EJ, Choi YH, Hong SH.
europepmc +1 more source
An update on the landscape of collagen bioactive fragments
The FEBS Journal, EarlyView.The remodeling of the extracellular matrix releases collagen bioactive fragments, which exert molecular functions and regulate numerous biological processes via several signaling pathways. Here, we summarize the latest findings describing the roles of major bioactive fragments from collagens I, IV, VI, and XVIII in various physiological and ...
Sylvie Ricard‐Blum, Julie Fradette
wiley +1 more source
Protocol for fabricating and characterizing microvessel-on-a-chip for human umbilical vein endothelial cells. [PDF]
STAR ProtocCacheux J +6 more
europepmc +1 more source
A noncanonical role for Jagged1 in endothelial mechanotransduction
The FEBS Journal, EarlyView.This study reveals a noncanonical role for Jagged1 in endothelial mechanotransduction. Shear stress modulates Jagged1 expression and subcellular localization. Loss of Jagged1 attenuates mechanotransduction and reduces Src, VEGFR2, and ERK signaling. Direct mechanical stimulation of Jagged1 induces activation of these signaling pathways.
Freddy Suarez Rodriguez +7 more
wiley +1 more source
Protective role of kallistatin in oxygen-glucose deprivation and reoxygenation in human umbilical vein endothelial cells. [PDF]
Clin Exp Emerg MedUm YW, Kwon WY, Seong SY, Suh GJ.
europepmc +1 more source
Journal of Periodontal Research, EarlyView.The scoping review summarizes the current preclinical and clinical evidence for the use of “cell‐free” therapies in craniofacial (periodontal, bone and soft‐tissue) regeneration. It also aims to highlight key challenges and strategies towards the clinical translation of these therapies.
Siddharth Shanbhag +6 more
wiley +1 more source
Involvement of retinoic acid‑inducible gene‑I in radiation‑induced senescence of human umbilical vein endothelial cells. [PDF]
Biomed RepSasaki F +4 more
europepmc +1 more source