Results 111 to 120 of about 28,868 (258)
Food Science &Nutrition, Volume 13, Issue 8, August 2025.The positive influence of berberine on the nervous system can be attributed to its diverse effects on multiple targets. The effects of berberine include its antioxidant, anti‐apoptotic, anti‐necroptotic, and anti‐inflammatory properties, as well as its ability to induce autophagy.
Xiaolan Wang +5 more
wiley +1 more source
Presynaptic APP levels and synaptic homeostasis are regulated by Akt phosphorylation of huntingtin
eLife, 2020 Studies have suggested that amyloid precursor protein (APP) regulates synaptic homeostasis, but the evidence has not been consistent. In particular, signaling pathways controlling APP transport to the synapse in axons and dendrites remain to be ...
Julie Bruyère +12 more
doaj +1 more source
Human Brain Mapping, Volume 46, Issue 11, 01 August 2025.Our study analyzed longitudinal diffusion MRI data from healthy and Huntington's disease (HD) individuals to investigate the dentato‐rubro‐thalamic tract (DRTT) in HD. Microstructural disruptions along the DRTT were linked to motor and cognitive impairments, suggesting cerebellar involvement in disease progression and highlighting DRTT alterations as ...
Zexi Wang +3 more
wiley +1 more source
The Journal of Cell Biology, 2005 ![Graphic][1] Cdk5 (red) phosphorylates htt (green) and protects it from caspases.A cyclin-dependent kinase protects neurons from toxic fragments of huntingtin (htt), according to Luo et al.
openaire +3 more sources
Detection of ubiquitinated huntingtin species in intracellular aggregates
Frontiers in Molecular Neuroscience, 2015 Protein conformation diseases, including polyglutamine diseases, result from the accumulation and aggregation of misfolded proteins. Huntington’s disease is one of nine diseases caused by an expanded polyglutamine repeat within the affected protein and ...
Katrin eJuenemann +2 more
doaj +1 more source
Reduced Fractalkine Levels Lead to Striatal Synaptic Plasticity Deficits in Huntington’s Disease
Frontiers in Cellular Neuroscience, 2020 Huntington’s disease (HD) is an inherited neurodegenerative disorder in which the striatum is the most affected brain region. Although a chronic inflammatory microglial reaction that amplifies disease progression has been described in HD patients, some ...
Anya Kim +40 more
doaj +1 more source
Journal of Biochemical and Molecular Toxicology, Volume 39, Issue 8, August 2025.Curcumin regulates several signaling pathways linked to neuroprotection, such as those that reduce oxidative stress, prevent Aβ formation, and decrease neuroinflammation. ABSTRACT Progressive neuronal loss and dysfunction characterize neurodegenerative diseases (NDs) such as Alzheimer's, Parkinson's, and Huntington's diseases, spinal cord injury, and ...
Md. Rezaul Islam +11 more
wiley +1 more source
The Ubiquitin-Proteasome Pathway in Huntington's Disease
The Scientific World Journal, 2008 The accumulation of mutant protein is a common feature of neurodegenerative disease. In Huntington's disease, a polyglutamine expansion in the huntingtin protein triggers neuronal toxicity.
Siddhartha Mitra, Steven Finkbeiner
doaj +1 more source
The effects of huntingtin-lowering: what do we know so far?
Degenerative Neurological and Neuromuscular Disease, 2019 Therapies targeting mutant huntingtin DNA, mRNA, and protein have a chance at becoming the first disease-modifying treatments for Huntington’s disease, a fatal inherited neurodegenerative disorder for which only symptom management treatments are ...
W. Kaemmerer, R. Grondin
semanticscholar +1 more source
Human-to-mouse prion-like propagation of mutant huntingtin protein
Acta Neuropathologica, 2016 Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder of the central nervous system (CNS) that is defined by a CAG expansion in exon 1 of the huntingtin gene leading to the production of mutant huntingtin (mHtt).
Iksoo Jeon +17 more
semanticscholar +1 more source