Results 131 to 140 of about 37,460 (168)

Exon 1-targeting miRNA reduces the pathogenic exon 1 HTT protein in Huntington's disease models. [PDF]

Brain
Sogorb-Gonzalez M, Landles C, Caron NS, Stam A, Osborne G, Hayden MR, Howland D, van Deventer S, Bates GP, Vallès A, Evers M.   +10 more
europepmc   +1 more source

Inhibitor-based modulation of huntingtin aggregation mechanisms mitigates fibril-induced cellular stress. [PDF]

Nat Commun
Jain G, Trombetta-Lima M, Matlahov I, Ribas HT, Chen T, Parlato R, Portale G, Dolga AM, van der Wel PCA.   +8 more
europepmc   +1 more source

Therapeutic approaches targeting aging and cellular senescence in Huntington's disease. [PDF]

CNS Neurosci Ther
Bhat AA, Moglad E, Afzal M, Thapa R, Almalki WH, Kazmi I, Alzarea SI, Ali H, Pant K, Singh TG, Dureja H, Singh SK, Dua K, Gupta G, Subramaniyan V.   +14 more
europepmc   +1 more source

Regulation of Mutant Huntingtin Mitochondrial Toxicity by Phosphomimetic Mutations within Its N-Terminal Region. [PDF]

J Neurosci
Yablonska S, Strohlein CE, Baranov SV, Yeh SM, Patel A, Singh T, Jauhari A, Kim J, Khattar NK, Li F, Wang X, Chang YF, Lee CYD, Yang XW, Carlisle DL, Friedlander RM.   +15 more
europepmc   +1 more source

Biodistribution and dosimetry of the PET radioligand [¹⁸F]CHDI-650 in mice for detection of mutant huntingtin aggregates. [PDF]

EJNMMI Res
Akkermans J, Miranda A, Verhaeghe J, Elvas F, Zajicek F, Bard J, Liu L, Khetarpal V, Doot R, Staelens S, Bertoglio D.   +10 more
europepmc   +1 more source

TDP-43 overexpression in the hypothalamus drives neuropathology, dysregulates metabolism and impairs behavior in mice. [PDF]

Acta Neuropathol Commun
Bergh S, Casadei N, Gabery S, Simonsson O, Duarte JMN, Kirik D, Nguyen HP, Petersén Å.   +7 more
europepmc   +1 more source

In-vitro Neuro-2a cytotoxicity analysis and molecular docking investigation on potential anti-amyloid agents from Adiantum lunulatum. [PDF]

Heliyon
Jerom JP, Jalal A, Sajan AL, Soman R, Nair RH, Narayanan SP.   +5 more
europepmc   +1 more source

Editorial: Plant and fungal extracts and metabolites in neurotherapy: exploring their pharmacology and potential clinical uses. [PDF]

Front Pharmacol
Hao J, Lavrov I, Zhou X.
europepmc   +1 more source

Decoding the genetic blueprints of neurological disorders: disease mechanisms and breakthrough gene therapies. [PDF]

Front Neurol
Saeed U, Piracha ZZ, Tariq MN, Syed S, Rauf M, Razaq L, Iftikhar MK, Maqsood A, Ahsan SM.   +8 more
europepmc   +1 more source