Results 151 to 160 of about 44,176 (282)
Protein Aggregates and Polyglutamine Tracts In Neurodegenerative Disease [PDF]
, 2018 The incidence of neurodegenerative diseases such as Alzheimer\u27s Disease, Parkinson\u27s Disease, Huntington\u27s Disease and other Polyglutamine Diseases is projected to dramatically increase throughout the developed world, and yet the pathology of ...
Mack, John
core +1 more source
Tissue Transglutaminase Does Not Contribute to the Formation of Mutant Huntingtin Aggregates [PDF]
, 2001 Wanjoo Chun +4 more
openalex +1 more source
Charge within Nt17 peptides modulates huntingtin aggregation and initial lipid binding events [PDF]
, 2023 Alyssa R. Stonebraker +5 more
openalex +1 more source
Navigating the neuronal recycling bin: Another look at huntingtin in coordinating autophagy
Autophagy ReportsNeurons, as post–mitotic and long–lived cells, rely heavily on autophagy to maintain cellular homoeostasis and ensure proper function. Huntingtin (HTT), a protein central to Huntington’s disease (HD), has emerged as a putative multifunctional regulator ...
Thomas J. Krzystek, Shermali Gunawardena
doaj +1 more source
AAV5-miHTT gene therapy for Huntington disease: lowering both huntingtins [PDF]
, 2020 Melvin M. Evers, Pavlina Konstantinova
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Advanced SciencePolyglutamine (polyQ) tract length expansion (≥ 36 residues) within the N‐terminal exon‐1 of Huntingtin (Httex1) leads to Huntington's disease, a neurodegenerative condition marked by the presence of intranuclear Htt inclusions.
Priyesh Mohanty +2 more
doaj +1 more source
Mutant Huntingtin promotes autonomous microglia activation via myeloid lineage-determining factors
, 2014 Andrea Crotti +9 more
openalex +1 more source