Results 181 to 190 of about 49,474 (299)

Huntingtin Expression Stimulates Endosomal–Lysosomal Activity, Endosome Tubulation, and Autophagy [PDF]

, 2000
Kimberly B. Kegel, Manho Kim, Ellen Sapp, Charmian McIntyre, José G. Castaño, Neil Aronin, Marian DiFiglia   +6 more
openalex   +1 more source

Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage [PDF]

, 2017
To test the hypotheses that mutant huntingtin protein length and wild-type huntingtin dosage have important effects on disease-related transcriptional dysfunction, we compared the changes in mRNA in seven genetic mouse models of Huntington's disease (HD)
Albin, Roger, Augood, Sarah J., Bates, Gillian P., Becanovic, Kristina, Cha, Jang-Ho J., Delorenzi, Mauro, Dunnett, Stephen B., Faull, Richard L.M., Ferrante, Robert J., Goldstein, Darlene R., Hannan, Anthony J., Hayden, Michael R., Hodges, Angela, Jones, Lesley, Kooperberg, Charles, Kuhn, Alexandre, Leavitt, Blair R., Luthi-Carter, Ruth, Olson, James M., Pouladi, Mahmoud A., Sathasivam, Kirupa, Sengstag, Thierry, Shelbourne, Peggy, Strand, Andrew D.   +23 more
core  

Expression and protein-binding studies of the EEN gene family, new interacting partners for dynamin, synaptojanin and huntingtin proteins [PDF]

, 2000
Chi Wai Eric So, MH Sham, Sze Lun CHEW, Ngai Cheung, C K So, Sookja Kim Chung, Carlos Caldas, Markus Wiedemann, Li Chong Chan   +8 more
openalex   +1 more source

Preserved VPS13A distribution and expression in Huntington’s disease: divergent mechanisms of action for similar movement disorders?

Frontiers in Neuroscience
VPS13A disease and Huntington’s disease (HD) are two basal ganglia disorders that may be difficult to distinguish clinically because they have similar symptoms, neuropathological features, and cellular dysfunctions with selective degeneration of the ...
Esther García-García, Esther García-García, Esther García-García, Maria Carreras-Caballé, Maria Carreras-Caballé, Albert Coll-Manzano, Alba Ramón-Lainez, Alba Ramón-Lainez, Alba Ramón-Lainez, Gisela Besa-Selva, Gisela Besa-Selva, Gisela Besa-Selva, Esther Pérez-Navarro, Esther Pérez-Navarro, Esther Pérez-Navarro, Cristina Malagelada, Cristina Malagelada, Cristina Malagelada, Jordi Alberch, Jordi Alberch, Jordi Alberch, Jordi Alberch, Mercè Masana, Mercè Masana, Mercè Masana, Manuel J. Rodríguez, Manuel J. Rodríguez, Manuel J. Rodríguez   +27 more
doaj   +1 more source

Analysis of CAG and CCG repeats in Huntingtin gene among HD patients and normal populations of India [PDF]

, 2000
Sreemanta Pramanik, P. Basu, Prasanta K. Gangopadhaya, Krishna K. Sinha, Dilip Kumar Jha, Srish Sinha, Shyamal Kumar Das, Bibek K Maity, Amitava Mukherjee, Sushanta Roychoudhuri, Partha P. Majumder, Nitai P. Bhattacharyya   +11 more
openalex   +1 more source

Inhibiting Caspase Cleavage of Huntingtin Reduces Toxicity and Aggregate Formation in Neuronal and Nonneuronal Cells [PDF]

, 2000
Cheryl L. Wellington, Roshni R. Singaraja, Lisa Ellerby, Jane Savill, Sophie Roy, Blair R. Leavitt, Elena Cattaneo, Abigail S. Hackam, Alan H. Sharp, Nancy A. Thornberry, Donald W. Nicholson, Dale E. Bredesen, Michael R. Hayden   +12 more
openalex   +1 more source

Huntingtin: an iron-regulated protein essential for normal nuclear and perinuclear organelles [PDF]

, 2000
Paige Hilditch-Maguire
openalex   +1 more source

Inhibition of huntingtin fibrillogenesis by specific antibodies and small molecules: Implications for Huntington's disease therapy [PDF]

, 2000
Volker Heiser, Eberhard Scherzinger, Annett Boeddrich, Eckhard Nordhoff, Rudi Lurz, Nancy Schugardt, Hans Lehrach, Erich E. Wanker   +7 more
openalex   +1 more source

The biological function of the Huntingtin protein and its relevance to Huntington’s Disease pathology [PDF]

, 2011
available in PMC 2011 December 14.Huntington’s Disease is an adult-onset dominant heritable disorder characterized by progressive psychiatric disruption, cognitive deficits, and loss of motor coordination.
Littleton, J. Troy, Schulte, Joost
core  

Activation of MLK2-mediated Signaling Cascades by Polyglutamine-expanded Huntingtin [PDF]

, 2000
Ya Fang Liu, Donna S. Dorow, John Marshall   +2 more
openalex   +1 more source