Neurobiology of Disease, 1999 Huntington's disease (HD) is caused by an expanded glutamine tract, which confers a novel aggregation-promoting property on the 350-kDa huntingtin protein.
Francesca Persichetti +6 more
doaj
Quantifying Huntingtin Protein in Human Cerebrospinal Fluid Using a Novel Polyglutamine Length-Independent Assay. [PDF]
J Huntingtons Dis, 2022 Fodale V +5 more
europepmc +1 more source
Profilin reduces aggregation and phase separation of huntingtin N-terminal fragments by preferentially binding to soluble monomers and oligomers [PDF]
, 2018 Aimin Li +6 more
core +2 more sources
A C-terminal ataxin-2 disordered region promotes Huntingtin protein aggregation and neurodegeneration in Drosophila models of Huntington's disease. [PDF]
G3 (Bethesda), 2021 Huelsmeier J +3 more
europepmc +1 more source
Interaction of Huntingtin-associated Protein-1 with Kinesin Light Chain [PDF]
, 2005 John R. McGuire +3 more
openalex +1 more source
Allele-Specific Knockdown of Mutant Huntingtin Protein via Editing at Coding Region Single Nucleotide Polymorphism Heterozygosities. [PDF]
Hum Gene Ther, 2022 Oikemus SR +14 more
europepmc +1 more source
A Protein Interaction Network Links GIT1, an Enhancer of Huntingtin Aggregation, to Huntington’s Disease [PDF]
, 2005 Heike Goehler +23 more
openalex +1 more source
Automated four-dimensional long term imaging enables single cell tracking within organotypic brain slices to study neurodevelopment and degeneration. [PDF]
, 2019 Current approaches for dynamic profiling of single cells rely on dissociated cultures, which lack important biological features existing in tissues. Organotypic slice cultures preserve aspects of structural and synaptic organisation within the brain and ...
Barch, Mariya +11 more
core
Cloning, expression, purification, crystallization and preliminary crystallographic analysis of pseudo death-effector domain of HIPPI, a molecular partner of Huntingtin-interacting protein HIP-1 [PDF]
, 2006 Manisha Banerjee +4 more
openalex +1 more source
Mutant huntingtin enhances activation of dendritic Kv4 K+ channels in striatal spiny projection neurons [PDF]
, 2019 Huntington\u27s disease (HD) is initially characterized by an inability to suppress unwanted movements, a deficit attributable to impaired synaptic activation of striatal indirect pathway spiny projection neurons (iSPNs).
Carrillo-Reid, Luis +13 more
core +1 more source