Results 71 to 80 of about 33,531 (157)

Emerging Links Between Ferroptosis and Neurodegeneration: Implications for Disease Mechanisms and Nutraceutical Interventions

Food Science &Nutrition, Volume 13, Issue 6, June 2025.
Ferroptosis, a controlled cell death, is driven by iron and characterized by reactive oxygen species and lipid peroxidation. The impact of lipid peroxides, GSH/GPX4, and iron metabolism–targeting small molecule inhibitors is discussed. Nucleic acids, proteins, and phytochemicals are implicated as inhibitors of ferroptosis.
Anwar Ali, Quratulain Babar, Ayesha Saeed, Domenico Sergi, Nenad Naumovski, Isam A. Mohamed Ahmed, Ghalia Shamlan, Halah Abdulrahman Hafiz, Muhammad Faisal Manzoor, Joanna Trafialek, Felix Kwashie Madilo   +10 more
wiley   +1 more source

Biomarkers for Huntington's disease: an update [PDF]

, 2012
Huntington's disease (HD) is a devastating autosomal-dominant neurodegenerative condition caused by a CAG repeat expansion in the gene encoding huntingtin which is characterised by progressive motor impairment, cognitive decline and neuropsychiatric ...
Scahill, RI, Tabrizi, SJ, Wild, EJ
core   +1 more source

The Nasal–Brain Drug Delivery Route: Mechanisms and Applications to Central Nervous System Diseases

MedComm, Volume 6, Issue 6, June 2025.
Τhe BBB restricts CNS drug delivery. NBDD bypasses the BBB via olfactory/trigeminal routes, enabling CNS delivery of therapeutic (small molecules, biologics, nucleic acids) for neurodegenerative/psychiatric disorders and brain tumors using advanced NBDD delivery systems (e.g nanocarriers) to enhance targeting and bioavailability.
Yi Qiu, Shiyuan Huang, Li Peng, Li Yang, Guosong Zhang, Tao Liu, Fang Yan, Xi Peng   +7 more
wiley   +1 more source

Letter to the editor: autoimmune pathogenic mechanisms in Huntington’s disease [PDF]

, 2018
Letter to the Editor: Autoimmune pathogenic mechanisms in Huntington's ...
DE VINCENTIIS, Marco, De Virgilio, A, Fusconi, M, GRECO, Antonio, Inghilleri, M, Ralli, M   +5 more
core   +1 more source

Polyglutamine expansion induced dynamic misfolding of androgen receptor

Protein Science, Volume 34, Issue 6, June 2025.
Abstract Spinal bulbar muscular atrophy (SBMA) is caused by a polyglutamine expansion (pQe) in the N‐terminal transactivation domain of the human androgen receptor (AR‐NTD), resulting in a combination of toxic gain‐ and loss‐of‐function mechanisms. The structural basis of these processes has not been resolved due to the disordered nature of the NTD ...
Laurens W. H. J. Heling, Vahid Sheikhhassani, Julian Ng, Morris van Vliet, Alba Jiménez‐Panizo, Andrea Alegre‐Martí, Jaie Woodard, Willeke van Roon‐Mom, Iain J. McEwan, Eva Estébanez‐Perpiñá, Alireza Mashaghi   +10 more
wiley   +1 more source

Quantification Assays for Total and Polyglutamine-Expanded Huntingtin Proteins

PLoS ONE, 2014
The expansion of a CAG trinucleotide repeat in the huntingtin gene, which produces huntingtin protein with an expanded polyglutamine tract, is the cause of Huntington's disease (HD). Recent studies have reported that RNAi suppression of polyglutamine-expanded huntingtin (mutant HTT) in HD animal models can ameliorate disease phenotypes.
Faywell Albertus, Marieke Lamers, Kristiina Pulli, Wolfgang Reindl, Melanie A. Smith, Sipke Dijkstra, Ignacio Munoz-Sanjuan, Ivette Boogaard, Agnieszka Szynol, George McAllister, Michela Tessari, Frank Herrmann, Douglas Macdonald, David F. Fischer, Daniel Kordt   +14 more
openaire   +5 more sources

Evaluating the Potential of COL8A1 as a Therapeutic Target for Chemoresistance, Disease Progression, and a Prognostic Marker in Gastric Cancer

Journal of Cellular and Molecular Medicine, Volume 29, Issue 11, June 2025.
ABSTRACT This study aimed to identify key genes associated with post‐chemotherapy recurrence in gastric cancer patients. Gene expression data from multiple cohorts were analysed to determine differentially expressed genes between recurrent and non‐recurrent cases. A prognostic risk model incorporating COL8A1, HSPB7 and SLIT2 was developed and validated
Chao Xu, MuZhen He, HongYuan Chen, LiangJie Chi, XiangYu Wang, ShuYuan Li, QingShui Wang, Yao Lin, FangQin Xue   +8 more
wiley   +1 more source

Mitochondrial dynamics–fusion, fission, movement, and mitophagy–in neurodegenerative diseases [PDF]

, 2009
Neurons are metabolically active cells with high energy demands at locations distant from the cell body. As a result, these cells are particularly dependent on mitochondrial function, as reflected by the observation that diseases of mitochondrial ...
Alexander, Baloyannis, Banchs, Bossy-Wetzel, Brockmann, Cassidy-Stone, Chang, Chen, Cho, Clark, D. C. Chan, de Brito, Delettre, Dodson, Exner, Fransson, Frezza, Gispert, H. Chen, Hollenbeck, Kim, Kim, Li, Liot, Lustbader, Macaskill, Meeusen, Milone, Mortiboys, Okamoto, Orr, Park, Parone, Popp, Reis, Suen, Ten Dijke, Trushina, Wang, Waterham, Wood-Kaczmar, Zuchner, Z  chner   +42 more
core   +3 more sources

Reduced Palmitoylation of SQSTM1/p62 in Huntington Disease Is Associated With Impaired Autophagy

The FASEB Journal, Volume 39, Issue 9, 15 May 2025.
Sequestosome 1 (SQSTM1)/p62 is a receptor for autophagy required to deliver damaged organelles and aggregated proteins to the lysosome for degradation. SQSTM1 undergoes palmitoylation, the reversible addition of the saturated fatty acid palmitate to cysteines.
F. Abrar, M. C. Davies, Y. Alshehabi, A. Kumar, A. Dang, Y. T. N. Nguyen, J. Collins, N. S. Caron, J. S. Choudhary, S. S. Sanders, M. O. Collins, M. R. Hayden, D. D. O. Martin   +12 more
wiley   +1 more source

Oxidative stress parameters in plasma of Huntington's disease patients, asymptomatic Huntington's disease gene carriers and healthy subjects : a cross-sectional study [PDF]

, 2007
BACKGROUND : Animal data and postmortem studies suggest a role of oxidative stress in the Huntington's disease (HD), but in vivo human studies have been scarce.
Babić, Tomislav, Hećimović, Silva, Klepac, Nataša, Klepac, Ratimir, Relja, Maja, Trkulja, Vladimir   +5 more
core   +1 more source