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Psychiatric Clinics of North America, 1997
Huntington's disease is a genetically inherited degenerative neuropsychiatric disorder, characterized by motor alterations, including involuntary movements such as chorea, dementia and psychiatric disturbances. In this article, the authors review the clinical features of the disease. They also analyze some genetic and pathophysiologic aspects, that can
Mônica Santoro Haddad +1 more
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Huntington's disease is a genetically inherited degenerative neuropsychiatric disorder, characterized by motor alterations, including involuntary movements such as chorea, dementia and psychiatric disturbances. In this article, the authors review the clinical features of the disease. They also analyze some genetic and pathophysiologic aspects, that can
Mônica Santoro Haddad +1 more
openaire +3 more sources
Care Management Journals, 2008
Huntington's disease (HD) is a hereditary neurodegenerative disorder involving slow, progressive loss of functional capacities. Motor, psychiatric, and cognitive deterioration interfere with activities of independent living, gait, speech, and, ultimately, swallowing.
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Huntington's disease (HD) is a hereditary neurodegenerative disorder involving slow, progressive loss of functional capacities. Motor, psychiatric, and cognitive deterioration interfere with activities of independent living, gait, speech, and, ultimately, swallowing.
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Nature Reviews Disease Primers, 2015
Huntington disease is devastating to patients and their families - with autosomal dominant inheritance, onset typically in the prime of adult life, progressive course, and a combination of motor, cognitive and behavioural features. The disease is caused by an expanded CAG trinucleotide repeat (of variable length) in HTT, the gene that encodes the ...
Bates, Gillian P. +11 more
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Huntington disease is devastating to patients and their families - with autosomal dominant inheritance, onset typically in the prime of adult life, progressive course, and a combination of motor, cognitive and behavioural features. The disease is caused by an expanded CAG trinucleotide repeat (of variable length) in HTT, the gene that encodes the ...
Bates, Gillian P. +11 more
openaire +5 more sources
Current Treatment Options in Neurology, 2006
Although available treatments for Huntington's disease (HD) are imperfect, thoughtful application can positively impact quality of life. Dopamine antagonists can provide control of the troublesome hyperkinetic movements. These agents can also diminish the frequency of hallucinations and delusions when symptoms of psychosis occur. Classical neuroleptics
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Although available treatments for Huntington's disease (HD) are imperfect, thoughtful application can positively impact quality of life. Dopamine antagonists can provide control of the troublesome hyperkinetic movements. These agents can also diminish the frequency of hallucinations and delusions when symptoms of psychosis occur. Classical neuroleptics
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2018
Huntington disease is a monogenic neurodegenerative disorder that displays an autosomal-dominant pattern of inheritance. It is characterized by motor, psychiatric, and cognitive symptoms that progress over 15-20 years. Since the identification of the causative genetic mutation in 1993 much has been discovered about the underlying pathogenic mechanisms,
Ghosh, R, Tabrizi, SJ
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Huntington disease is a monogenic neurodegenerative disorder that displays an autosomal-dominant pattern of inheritance. It is characterized by motor, psychiatric, and cognitive symptoms that progress over 15-20 years. Since the identification of the causative genetic mutation in 1993 much has been discovered about the underlying pathogenic mechanisms,
Ghosh, R, Tabrizi, SJ
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Clinical Neuroscience Research, 2001
Abstract Huntington's disease (HD) is an autosomal dominant progressive neuropsychiatric disorder, characterized by abnormalities of movement, emotion and cognition. The most important pathological feature is selective neuronal loss, primarily in the striatum and cerebral cortex. HD is caused by the expansion of a CAG trinucleotide repeat in the gene
Russell L. Margolis, Christopher A. Ross
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Abstract Huntington's disease (HD) is an autosomal dominant progressive neuropsychiatric disorder, characterized by abnormalities of movement, emotion and cognition. The most important pathological feature is selective neuronal loss, primarily in the striatum and cerebral cortex. HD is caused by the expansion of a CAG trinucleotide repeat in the gene
Russell L. Margolis, Christopher A. Ross
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Irritability in Huntington’s disease
Psychiatry Research, 2012Irritability is a frequent neuropsychiatric symptom in patients with Huntington's disease (HD). The Irritability Scale (IS) and the irritability factor of the Problem Behaviours Assessment (PBA) was used to assess irritability among 130 HD mutation carriers and 43 verified non-carriers. The IS was tested using receiver operating characteristic analysis
Erik J. Giltay +7 more
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Huntington's disease: Brain imaging in Huntington's disease
2019Huntington's disease (HD) gene-carriers show prominent neuronal loss by end-stage disease, and the use of magnetic resonance imaging (MRI) has been increasingly used to quantify brain changes during earlier stages of the disease. MRI offers an in vivo method of measuring structural and functional brain change. The images collected via MRI are processed
Eileanoir B. Johnson, Sarah Gregory
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The American Journal of Nursing, 1979
ted by both sexes. Each child of an afflicted parent has a 50 percent chance of inheriting the disease. This risk continues uninterrupted from one generation to the next. Occasionally, a parent dies before the age when the symptoms characteristically appear, and this may give the impression, incorrectly, that Huntington's disease has skipped a ...
Stipe J, White D, Van Arsdale E
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ted by both sexes. Each child of an afflicted parent has a 50 percent chance of inheriting the disease. This risk continues uninterrupted from one generation to the next. Occasionally, a parent dies before the age when the symptoms characteristically appear, and this may give the impression, incorrectly, that Huntington's disease has skipped a ...
Stipe J, White D, Van Arsdale E
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Onconephrology: The intersections between the kidney and cancer
Ca-A Cancer Journal for Clinicians, 2021Mitchell H Rosner +2 more
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