Progression of motor subtypes in Huntington’s disease. a 6-year follow-up study [PDF]
, 2016 The objective of this study is to investigate the progression of predominantly choreatic and hypokinetic-rigid signs in Huntington's disease (HD) and their relationship with cognitive and general functioning over time.
Bentivoglio, A. R. +12 more
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Cortical circuit alterations precede motor impairments in Huntington's disease mice [PDF]
, 2019 Huntington's disease (HD) is a devastating hereditary movement disorder, characterized by degeneration of neurons in the striatum and cortex. Studies in human patients and mouse HD models suggest that disturbances of neuronal function in the neocortex ...
Arzberger, T. +10 more
core +1 more source
Novel Nut and Bolt Task Quantifies Motor Deficits in Premanifest and Manifest Huntington’s Disease
PLoS Currents, 2015 We investigated the use of a simple novel nut and bolt task in premanifest and manifest Huntington's disease (HD) patients to detect and quantify motor impairments at all stages of the disease.Premanifest HD (n=24), manifest HD (n=27) and control (n=32) participants were asked to screw a nut onto a bolt in one direction, using three different sized ...
Collins, Lucy M. +7 more
openaire +5 more sources
Huntington's disease is a multi-system disorder. [PDF]
, 2015 Huntingtons disease (HD) is one of the most common non-curable rare diseases and is characterized by choreic movements, psychiatric symptoms, and slowly progressive dementia.
Mielcarek, M
core +1 more source
Neural Stem Cells as a Model to Study Huntington’s Disease
, 2019 Huntington’s disease (HD) is a heritable neurodegenerative disorder that affects muscle coordination and diminishes cognitive abilities, by affecting the medium spiny neurons in the brain. In HD patients, neurons are damaged and destroyed because of the toxicity of the mutant Huntington protein (mHtt).
openaire +4 more sources
Neuropathological investigations of three murine models of Huntington’s disease [PDF]
, 2009 Huntington’s disease (HD) is a purely genetic neurodegenerative disorder affecting approximately 1 in 10,000 people. It is most commonly associated with excessive involuntary movement, or chorea, combined with varying degrees of other motor ...
Raza, A.S.
core
Dopamine Modulates the Susceptibility of Striatal Neurons to 3-Nitropropionic Acid in the Rat Model of Huntington’s Disease [PDF]
, 1998 David S. Reynolds +2 more
openalex +1 more source
Control of manipulative forces during unimanual and bimanual tasks in patients with Huntington’s disease [PDF]
, 2002 Deborah J. Serrien +2 more
openalex +1 more source
Single in vitro fertilization (IVF) cycle with blastomere biopsy for preimplantation genetic diagnosis (PGD) of Huntington’s disease, assisted hatching and cryopreservation results in healthy baby and subsequent ongoing pregnancy [PDF]
, 2002 M. Gvakharia +3 more
openalex +1 more source