Results 41 to 50 of about 93,886 (309)

Cortical and Striatal Circuits in Huntington's Disease

, 2020
Huntington's disease (HD) is a hereditary neurodegenerative disorder that typically manifests in midlife with motor, cognitive, and/or psychiatric symptoms.
Blumenstock, S., Dudanova, I.
core   +1 more source

The differential diagnosis of chorea [PDF]

, 2007
Chorea is a hyperkinetic movement disorder characterised by excessive spontaneous movements that are irregularly timed, randomly distributed and abrupt. In this article, the authors discuss the causes of chorea, particularly Huntington's disease and the ...
Tabrizi, SJ, Wild, EJ
core   +1 more source

Additional file 1 of Thalamostriatal degeneration contributes to dystonia and cholinergic interneuron dysfunction in a mouse model of Huntington’s disease

, 2020
Additional file 1: Experimental Timeline. Figure S1. Matrix Neuron Soma Area in WT and R6/2 mice. Figure S2. Striosome cell count in WT and R6/2 mice. Figure S3. Striosome Neuron Soma Area in WT and R6/2. Figure S4.
Crevier-Sorbo, Gabriel, Rymar, Vladimir, Crevier-Sorbo, Raphael, Sadikot, Abbas   +3 more
openaire   +1 more source

Memantine administration prevented chorea movement in Huntington’s disease: a case report

Journal of Medical Case Reports, 2023
Background Huntington’s disease is an autosomal dominant inherited disorder characterized by personality changes (such as irritability and restlessness) and psychotic symptoms (such as hallucinations and delusions).
Kazumasa Saigoh, Makito Hirano, Yoshiyuki Mitsui, Itsuki Oda, Atsuko Ikegawa, Makoto Samukawa, Keisuke Yoshikawa, Yuko Yamagishi, Susumu Kusunoki, Yoshitaka Nagai   +9 more
doaj   +1 more source

Evidence for dynamic and multiple roles for huntingtin in Ciona intestinalis [PDF]

, 2013
Although mutations in the huntingtin gene (HTT) due to poly-Q expansion cause neuropathology in humans (Huntington's disease; HD), the normal function(s) of the gene and its protein (HTT) remain obscure.
Brown, Euan R., Idris, Mohammed M, Thorndyke, Michael C   +2 more
core   +1 more source

Cortical and Striatal Functional Connectivity in Juvenile-Onset Huntington's Disease. [PDF]

Brain Sci
Barry A, Nopoulos PC.
europepmc   +3 more sources

Intrabody Gene Therapy Ameliorates Motor, Cognitive, and Neuropathological Symptoms in Multiple Mouse Models of Huntington's Disease [PDF]

, 2009
Huntington's disease (HD) is an autosomal dominant neurodegenerative disease resulting from the expansion of a glutamine repeat in the huntingtin (Htt) protein.
Ko, Jan, Patterson, Paul H., Southwell, Amber L.   +2 more
core   +2 more sources

Recommendations for the Use of Automated Gray Matter Segmentation Tools: Evidence from Huntington’s Disease

Frontiers in Neurology, 2017
The selection of an appropriate segmentation tool is a challenge facing any researcher aiming to measure gray matter (GM) volume. Many tools have been compared, yet there is currently no method that can be recommended above all others; in particular ...
Eileanoir B. Johnson, Sarah Gregory, Hans J. Johnson, Alexandra Durr, Blair R. Leavitt, Raymund A. Roos, Raymund A. Roos, Geraint Rees, Sarah J. Tabrizi, Rachael I. Scahill   +9 more
doaj   +1 more source

Integrated genomics and proteomics define huntingtin CAG length-dependent networks in mice. [PDF]

, 2016
To gain insight into how mutant huntingtin (mHtt) CAG repeat length modifies Huntington's disease (HD) pathogenesis, we profiled mRNA in over 600 brain and peripheral tissue samples from HD knock-in mice with increasing CAG repeat lengths.
A Dobin, A Hodges, A Kuhn, A Pal, A Reiner, A Valencia, Andreas Tebbe, B Zhang, B Zhang, BM Bolstad, C Zuccato, CA Ross, Christoph Schaab, Daniel J Lavery, David Howland, DI Shirasaki, Doxa Chatzopoulou, DV Zaykin, EH Aylward, Eliana Marisa Ramos, ES Deneris, ES Lein, Fuying Gao, G Fishell, GA Smith, Giovanni Coppola, HT Orr, I Al-Ramahi, IS Seong, Ismael Al-Ramahi, J Cox, J Cox, J Labbadia, JA Miller, JC Jacobsen, JE Phillips, Jeffrey P Cantle, Jeffrey S Aaronson, JF Gusella, JF Gusella, Jim Rosinski, JM Dowen, JM Van Raamsdonk, JP Vonsattel, Juan Botas, K Becanovic, K Monahan, K Sharma, Karla El-Zein, LB Menalled, LB Menalled, LB Menalled, LS Kaltenbach, M Biagioli, M Heiman, M MACDONALD, M Mann, M Mielcarek, MA Pouladi, MC Oldham, MI Love, MK Lobo, MT Lin, N Wang, Nan Wang, P Giles, P Grange, P Langfelder, P Langfelder, P Langfelder, P Langfelder, P Langfelder, Peter Langfelder, PF Durrenberger, RC Gentleman, S Anders, S Horvath, S Toyoda, Sandeep Deverasetty, Seung Kwak, Steve Horvath, T Geiger, T Lu, WE Johnson, WV Chen, X Gu, X Gu, X William Yang, XH Lu, Xiao-Hong Lu, Y Benjamini, Y Guo, Y Shen, Y Wang, Yining Zhao   +94 more
core   +1 more source

Test–Retest Reliability of Measures Commonly Used to Measure Striatal Dysfunction across Multiple Testing Sessions: A Longitudinal Study

Frontiers in Psychology, 2018
Cognitive impairment is common amongst many neurodegenerative movement disorders such as Huntington’s disease (HD) and Parkinson’s disease (PD) across multiple domains.
Clare E. Palmer, Douglas Langbehn, Sarah J. Tabrizi, Marina Papoutsi   +3 more
doaj   +1 more source