Results 51 to 60 of about 52,129 (204)
Frontiers in Psychology, 2018 Cognitive impairment is common amongst many neurodegenerative movement disorders such as Huntington’s disease (HD) and Parkinson’s disease (PD) across multiple domains.
Clare E. Palmer +3 more
doaj +1 more source
Health Care Delivery Practices in Huntington's Disease Specialty Clinics : An International Survey [PDF]
, 2016 The CHDI Foundation, Inc. funds Enroll-HD and the activities of the Enroll-HD Care Improvement Committee, including the present survey. We would like to acknowledge the Enroll-HD and REGISTRY administrative staff that assisted in the recruitment of sites
Edmondson, Mary +11 more
core +1 more source
Studies on the Q175 Knock-in Model of Huntington’s Disease Using Functional Imaging in Awake Mice: Evidence of Olfactory Dysfunction [PDF]
Frontiers in Neurology, 2014 Blood oxygen level dependent (BOLD) imaging in awake mice was used to identify differences in brain activity between wild-type, HETzQ175, and HOMzQ175 genotypes in response to the odor of almond. The study was designed to see how alterations in the huntingtin gene in a mouse model of Huntington's disease would affect the perception and processing of ...
Steven Toddes +5 more
openaire +3 more sources
Journal of General Physiology, 2021 Huntington’s disease (HD) is a fatal and progressive condition with severe debilitating motor defects and muscle weakness. Although classically recognized as a neurodegenerative disorder, there is increasing evidence of cell autonomous toxicity in skeletal muscle. We recently demonstrated that skeletal muscle fibers from the R6/2 model mouse of HD have
Kristiana Peraza +10 more
openaire +4 more sources
The cholesterol 24-hydroxylase activates autophagy and decreases mutant huntingtin build-up in a neuroblastoma culture model of Huntington’s disease [PDF]
, 2020 Objective Compromised brain cholesterol turnover and altered regulation of brain cholesterol metabolism have been allied with some neurodegenerative diseases, including Huntington’s disease (HD).
Alves, Sandro +12 more
core +1 more source
, 2016 Modules in blood significantly correlated with HD. This file contains the 8 modules that were identified in blood as being correlated to the HD phenotype. The file describes each module according to the most representative annotations per semantic category (biological processes, cellular component, molecular function, disease or syndrome). (DOC 16.5 kb)
Mina, Eleni +8 more
openaire +1 more source
Health-related quality of life in Huntington’s Disease patients: a comparison of proxy assessment and patient self-rating using the disease-specific Huntington’s Disease health-related quality of life questionnaire (HDQoL) [PDF]
, 2012 Huntington’s disease (HD) is a fatal, neurodegenerative disease for which there is no known cure. Proxy evaluation is relevant for HD as its manifestation might limit the ability of persons to report their health-related quality of life (HrQoL).
A Aubeeluck +39 more
core +1 more source
, 2016 Significantly correlated modules in brain. This file contains the modules from each brain region (caudate, BA4, BA9 and cerebellum) that were associated with the disease phenotype. The numbers (P v a l u e) indicate the correlation of each module with the disease phenotype. Green: negative correlation, red: positive correlation.
Mina, Eleni +8 more
openaire +1 more source
Huntington’s disease cerebrospinal fluid seeds aggregation of mutant huntingtin [PDF]
Molecular Psychiatry, 2015 Huntington's disease (HD), a progressive neurodegenerative disease, is caused by an expanded CAG triplet repeat producing a mutant huntingtin protein (mHTT) with a polyglutamine-repeat expansion. Onset of symptoms in mutant huntingtin gene-carrying individuals remains unpredictable.
Wah Chiu +23 more
openaire +6 more sources