Results 71 to 80 of about 93,886 (309)

Huntington\u27s Disease--A Review [PDF]

, 2016
Huntington’s disease is degenerative and effects both cognitive and motor functioning, beginning in the 20s and continuing a decline for about two decades until death.
Dunn, Christen
core   +1 more source

Additional file 7: of The dynamics of early-state transcriptional changes and aggregate formation in a Huntingtonâ s disease cell model

, 2017
Expression profiles for all fourteen clusters created using the CLICK algorithm (Expander). Expression patterns for all clusters were standardized to mean zero and standard deviation one. Error bars correspond to one standard deviation. (PDF 360Â kb)
Hagen, Martijn Van, Piebes, Diewertje, Leeuw, Wim De, Vuist, Ilona, Roon-Mom, Willeke Van, Moerland, Perry, Pernette Verschure   +6 more
openaire   +1 more source

Additional file 1: of Unmet needs for healthcare and social support services in patients with Huntingtonâ s disease: a cross-sectional population-based study

, 2015
The Needs and Provision Complexity Scale. (PDF 102 kb)
Walsem, Marleen Van, Howe, Emilie, Iversen, Kristin, Frich, Jan, Andelic, Nada   +4 more
openaire   +1 more source

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source

Rating scales for behavioural symptoms in Huntington's Disease: critique and recommendations [PDF]

, 2016
Behavioral symptoms are an important feature of Huntington’s disease and contribute to impairment in quality of life. The Movement Disorder Society commissioned the assessment of the clinimetric properties of rating scales in Huntington’s disease in ...
Bachoud-Levi, Banaszkiewicz, Baudic, Beglinger, Beglinger, Beglinger, Blackwell, Brugger, Brusa, Burns, Callaghan, Chatterjee, Como, Craig, Craufurd, Curtis, Dale, Decruyenaere, Delmaire, Dominguez, DudokdeWit, Duff, Duijn, Duijn, Duijn, Duijn, Epping, Gargiulo, Gray, Group, Hamilton, Hamilton, Ho, Holl, Horowitz, Hubers, Jankovic, Justo, Kingma, Kloppel, Kulisevsky, Leroi, Levy, Litvan, Lucetti, Lundervold, Lundin, Marder, Mayberg, Mestre, Meyer, Moulton, Naarding, Nimmagadda, Orth, Paulsen, Paulsen, Peavy, Pflanz, Poudel, Reedeker, Reedeker, Rees, Reilmann, Rickards, Rickards, Schrag, Sitek, Sitek, Snaith, Souza, Spielberger, Sprengelmeyer, Starkstein, Stout, Tabrizi, Tippett, Vassos, Vitale, Watson, Wetzel, Wing, Wong, Yebenes, Zappacosta   +84 more
core   +1 more source

Nanophotonic Strategies for Chiral Biosensing: Nanoparticles, Metasurfaces, Magneto‐Optical, and Quantum Approaches

Advanced Photonics Research, EarlyView.
Recent advances in nanophotonics‐based chiral biosensing approaches are comprehensively reviewed, highlighting key trends, advantages, and limitations of each technology. Special attention is given to emerging strategies that exploit magneto‐optical and quantum plasmonic phenomena to enhance sensitivity down to the level of a few molecules, or even a ...
Jorge Ricardo Mejía‐Salazar
wiley   +1 more source

Visual control improves the accuracy of hand positioning in Huntington’s disease

Aktualności Neurologiczne, 2017
Background: The study aimed at demonstrating dependence of visual feedback during hand and finger positioning task performance among Huntington’s disease patients in comparison to patients with Parkinson’s disease and cervical dystonia.
Emilia J. Sitek, Witold Sołtan, Agnieszka Konkel, Dariusz Wieczorek, Michał Schinwelski, Piotr Robowski, Jarosław Sławek   +6 more
doaj   +1 more source

How young people find out about their family history of Huntington's disease [PDF]

, 2009
Family communication about adult-onset hereditary illness can be problematic, leaving some relatives inadequately informed or ignorant of their risk.
Forrest Keenan, Karen, McKee, Lorna, Miedzybrodzka, Zosia, Simpson, Sheila A., van Teijlingen, Edwin   +4 more
core   +1 more source

Additional file 1: of The dynamics of early-state transcriptional changes and aggregate formation in a Huntingtonâ s disease cell model

, 2017
Additional probes used on the microarray. Probes added to the default Nimblegen library to interrogate additional rat genes (A) or as expression controls for eGFP-Htt levels (B). (PDF 34Â kb)
Hagen, Martijn Van, Piebes, Diewertje, Leeuw, Wim De, Vuist, Ilona, Roon-Mom, Willeke Van, Moerland, Perry, Pernette Verschure   +6 more
openaire   +1 more source

Allosteric Modulation of Pathological Ataxin‐3 Aggregation: A Path to Spinocerebellar Ataxia Type‐3 Therapies

Advanced Science, EarlyView.
This study uncovers a new allosteric site in the Josephin domain of ataxin‐3 targeted by the molecular tweezer CLR01, which modulates protein aggregation, improves synaptic function in neuronal cells, and delays motor dysfunction in animal models.
Alexandra Silva, Sara Duarte‐Silva, Pedro M. Martins, Beatriz Rodrigues, Débora Serrenho, Daniela Vilasboas‐Campos, Andreia Teixeira‐Castro, Julio Vieyto‐Nuñez, Joel Mieres‐Perez, Francisco Figueiredo, Martyna Podlasiak, Tatiana Van‐der‐Kellen, Joana Fraga, James Noble, Carter Lantz, Niki Sepanj, Daniela Monteiro‐Fernandes, Sara Guerreiro, Andreia Neves‐Carvalho, Joana Pereira‐Sousa, Frank‐Gerrit Klärner, Thomas Schrader, Joseph A. Loo, Annalisa Pastore, Elsa Sanchez‐Garcia, Gal Bitan, Ana Luísa Carvalho, Patrícia Maciel, Sandra Macedo‐Ribeiro   +28 more
wiley   +1 more source