Results 71 to 80 of about 52,129 (204)

Additional file 7: of The dynamics of early-state transcriptional changes and aggregate formation in a Huntingtonâ s disease cell model

, 2017
Expression profiles for all fourteen clusters created using the CLICK algorithm (Expander). Expression patterns for all clusters were standardized to mean zero and standard deviation one. Error bars correspond to one standard deviation. (PDF 360Â kb)
Hagen, Martijn Van, Piebes, Diewertje, Leeuw, Wim De, Vuist, Ilona, Roon-Mom, Willeke Van, Moerland, Perry, Pernette Verschure   +6 more
openaire   +1 more source

deutetrabenazine for the treatment of chorea associated with Huntington’s disease

Health Psychology Research, 2022
This is a comprehensive review of the literature regarding the use of Deutetrabenazine in treating chorea associated with Huntington’s disease. Unfortunately, treatment has been limited for many aspects of this neurodegenerative disease.
Harshit Gupta, Wil Perkins, Cain Stark, Sathya Kikkeri, Juyeon Kakazu, Adam D. Kaye, Alan D. Kaye   +6 more
doaj   +1 more source

Precise CAG repeat contraction in a Huntington’s Disease mouse model is enabled by gene editing with SpCas9-NG

Communications Biology, 2021
Seiya Oura and Taichi Noda et al. overcome the challenge of gene editing in CAG repeats, such as those causing Huntington’s Disease, using their recently developed SpCas9-NG variant. They demonstrate that SpCas9-NG can precisely edit and contract the CAG
Seiya Oura, Taichi Noda, Naoko Morimura, Seiji Hitoshi, Hiroshi Nishimasu, Yoshitaka Nagai, Osamu Nureki, Masahito Ikawa   +7 more
doaj   +1 more source

Small, Seeding-Competent Huntingtin Fibrils Are Prominent Aggregate Species in Brains of zQ175 Huntington’s Disease Knock-in Mice

Frontiers in Neuroscience, 2021
The deposition of mutant huntingtin (mHTT) protein aggregates in neurons of patients is a pathological hallmark of Huntington’s disease (HD). Previous investigations in cell-free and cell-based disease models showed mHTT exon-1 (mHTTex1) fragments with ...
Franziska Schindler, Nicole Praedel, Nancy Neuendorf, Severine Kunz, Sigrid Schnoegl, Michael A. Mason, Bridget A. Taxy, Gillian P. Bates, Ali Khoshnan, Josef Priller, Josef Priller, Josef Priller, Jan Grimm, Marcel Maier, Annett Boeddrich, Erich E. Wanker   +15 more
doaj   +1 more source

Additional file 1 of Identify Huntingtonâ s disease associated genes based on restricted Boltzmann machine with RNA-seq data

, 2017
Supplementary Material. The detail derivation process for solving the gradients of RBMs learning is given in the Supplementary Material. (PDF 321 kb)
Jiang, Xue, Zhang, Han, Duan, Feng, Xiongwen Quan   +3 more
openaire   +1 more source

Clinical Manifestation of Juvenile and Pediatric HD Patients: A Retrospective Case Series

Brain Sciences, 2020
Background: Studies on the clinical manifestation and course of disease in children suffering from Huntington’s disease (HD) are rare. Case reports of juvenile HD (onset ≤ 20 years) describe heterogeneous motoric and non-motoric symptoms, often ...
Jannis Achenbach, Charlotte Thiels, Thomas Lücke, Carsten Saft   +3 more
doaj   +1 more source

Quantification of mutant huntingtin protein in cerebrospinal fluid from Huntington's disease patients. [PDF]

, 2015
Quantification of disease-associated proteins in the cerebrospinal fluid (CSF) has been critical for the study and treatment of several neurodegenerative disorders; however, mutant huntingtin protein (mHTT), the cause of Huntington's disease (HD), is at ...
Andreas Weiss, Benjamini, Blair R. Leavitt, Douglas Langbehn, Douglas Macdonald, Edward J. Wild, Henrik Zetterberg, James R.C. Miller, Jeromin, Ko, Lewczuk, Nicola Robertson, Rainer Kuhn, Roberto Boggio, Rosengren, Salman Haider, Sarah J. Tabrizi   +16 more
core   +1 more source

Basal ganglia role in learning rewarded actions and executing previously learned choices: Healthy and diseased states [PDF]

, 2020
The basal ganglia (BG) is a collection of nuclei located deep beneath the cerebral cortex that is involved in learning and selection of rewarded actions. Here, we analyzed BG mechanisms that enable these functions.
Atwood, Brady, Kuznetsov, Alexey, Mulcahy, Garrett   +2 more
core   +1 more source

Influence of Competing Distractors on Response Selection in Huntington's Disease and Parkinson's Disease

Cognitive Neuropsychology, 2001
Current theories of the basal ganglia suggest a functional role in filtering stimuli that are competing for response selection. We hypothesised that damage to the basal ganglia, as occurs in Huntington's disease (HD) and Parkinson's disease (PD), may alter the effects of distractors on this filtering process.
Stout, Julie C., Wylie, Scott, Simone, Patricia M., Siemers, Eric R.   +3 more
openaire   +4 more sources

Huntington's disease: An immune perspective [PDF]

, 2011
Copyright © 2011 Annapurna Nayaketal. This article has been made available through the Brunel Open Access Publishing Fund.Huntington's disease (HD) is a progressive neurodegenerative disorder that is caused by abnormal expansion of CAG trinucleotide ...
Ansar, R, Bonifati, DM, Kishore, U, Nayak, A, Verma, SK   +4 more
core   +3 more sources