Results 81 to 90 of about 52,129 (204)

Metformin treatment reduces motor and neuropsychiatric phenotypes in the zQ175 mouse model of Huntington disease

Experimental and Molecular Medicine, 2019
Huntington’s disease: Diabetes drug limits disease-related degeneration in mice Metformin, an existing drug for diabetes, shows promise in alleviating symptoms of early Huntington’s disease in mouse models. Huntington’s disease is a genetic disorder that
Ana Sanchis, María Adelaida García-Gimeno, Antonio José Cañada-Martínez, María Dolores Sequedo, José María Millán, Pascual Sanz, Rafael P. Vázquez-Manrique   +6 more
doaj   +1 more source

A shared mechanism of muscle wasting in cancer and Huntington's disease. [PDF]

, 2015
Skeletal muscle loss and dysfunction in aging and chronic diseases is one of the major causes of mortality in patients, and is relevant for a wide variety of diseases such as neurodegeneration and cancer.
Constantinou C, Inui A, Magnusson‐Lind A, Murphy KT, Zielonka D   +4 more
core   +2 more sources

Additional file 6: Figure S2. of Similar striatal gene expression profiles in the striatum of the YAC128 and HdhQ150 mouse models of Huntingtonâ s disease are not reflected in mutant Huntingtin inclusion prevalence

, 2015
Analysis of the overlap of changes in gene expression in the YAC128 striatum at A. 6Â months of age B. 12 months of age and C. 18 months of age compared with other HD model mouse striata and human brain. Frequency represents the fraction of the top 200 HdhQ150 expression changes that map to a particular bin of ranked data (1000 genes per bin) in the ...
Zubeyde Bayram-Weston, Stone, Timothy, Giles, Peter, Elliston, Linda, Nari Janghra, Higgs, Gemma, Holmans, Peter, Dunnett, Stephen, Brooks, Simon, Jones, Lesley   +9 more
openaire   +1 more source

Juvenile Huntington’s disease

Анналы клинической и экспериментальной неврологии, 2017
Juvenile Huntingtons disease (JHD) manifests in 1st2nddecades of life and accounts for 29% of all cases ofHuntingtons disease; its pathogenic mechanisms are related togenetic anticipation and imprinting.
G. E. Rudenskaya, D. A. Savvin, V. P. Fedotov, S. A. Kurbatov, A. V. Polyakov, N. M. Galeeva   +5 more
doaj   +1 more source

Integrative enrichment analysis of gene expression based on an artificial neuron

BMC Medical Genomics, 2021
Background Huntington’s disease is a kind of chronic progressive neurodegenerative disease with complex pathogenic mechanisms. To data, the pathogenesis of Huntington’s disease is still not fully understood, and there has been no effective treatment. The
Xue Jiang, Weihao Pan, Miao Chen, Weidi Wang, Weichen Song, Guan Ning Lin   +5 more
doaj   +1 more source

Identifying Morphological and Functional Changes in a Caenorhabditis elegans Neuronal Aging Model of Huntington’s Disease [PDF]

, 2012
• Evaluate the effects of aging on neuronal morphology and gentle touch response in a C. elegans model of Huntington's disease • Establish that our RNAi method in our two genetic strains, Huntington’s disease model ID1 and control ID245, is selective ...
Parker, Cyrena
core  

Effects of Exercise Environment and Protocol Intensity on the Efficacy of Rehabilitation Care for Patients with Huntington’s Disease: A Comprehensive Review

International Journal of Exercise Science, 2019
Huntington’s disease (HD) is a neurodegenerative disease caused by astrogliosis of the putamen and caudate nucleus. Motor symptoms include progressive chorea, leading to deficits in gait, motor function, and quality of life. While many studies have examined the effects of therapeutic exercise on these factors in individuals with HD, the efficacy of ...
Dolbow, James D, Ly, Hau, Elwert, Nicholas, Gassler, John   +3 more
openaire   +3 more sources

Data-driven Huntington’s disease progression modelling and estimation of societal cost in the UK

Royal Society Open Science
We develop a Huntington’s disease (HD) progression model and integrate this with a novel economic model, accounting for the major factors of the HD’s societal cost.
Andrew Pollard, Danica Greetham, James Myatt, Hugh Rickards, Cath Stanley, Dave Dungate   +5 more
doaj   +1 more source

Intrabody Gene Therapy Ameliorates Motor, Cognitive, and Neuropathological Symptoms in Multiple Mouse Models of Huntington's Disease [PDF]

, 2009
Huntington's disease (HD) is an autosomal dominant neurodegenerative disease resulting from the expansion of a glutamine repeat in the huntingtin (Htt) protein.
Ko, Jan, Patterson, Paul H., Southwell, Amber L.   +2 more
core   +2 more sources

Nuclear Receptors as Therapeutic Targets for Neurodegenerative Diseases: Lost in Translation [PDF]

, 2019
Neurodegenerative diseases are characterized by a progressive loss of neurons that leads to a broad range of disabilities, including severe cognitive decline and motor impairment, for which there are no effective therapies.
Codocedo, Juan F., Landreth, Gary E., Moutinho, Miguel, Puntambekar, Shweta S.   +3 more
core   +1 more source