Results 161 to 170 of about 4,132 (213)

Huperzine A, a novel promising acetylcholinesterase inhibitor

NeuroReport, 1996
The effects of huperzine A on memory impairments induced by scopolamine were evaluated using a radial maze task and inhibition of cholinesterase in vitro compared with the effects of E2020 and tacrine. Scopolamine (0.2 mg kg-1) significantly impaired spatial memory in rats. Huperzine A (0.1-0.4 mg kg-1, p.o.), E2020 (0.5-1.0 mg kg-1, p.o.) and tacrine (
D H, Cheng, H, Ren, X C, Tang
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Synthesis of (±)-desamino huperzine A

Tetrahedron Letters, 2000
The first synthesis of desamino huperzine A 2 is described. Key steps are a double Michael addition into benzoquinone monoketal 4, a regiocontrolled double bond isomerisation and a novel pyridone synthesis involving a Michael addition of a ß-keto ester into acrylonitrile. (C) 2000 Elsevier Science Ltd.
Högenauer, Klemens, Baumann, Karl, Mulzer, Johann   +2 more
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A total synthesis of (±)-huperzine A

Tetrahedron Letters, 1989
Abstract The first total synthesis of (±)-huperzine A, a new lycopodium alkaloid is described.
Ligang Qian, Ruyun Ji
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Microbial transformation of (−)-Huperzine A

Tetrahedron Letters, 2010
Five products were yielded from the transformation of (−)-Huperzine A (1) by Streptomyces griseus CACC 200300. Their structures were determined as 16-hydroxyl huperzine A (2), 14α-hydroxyl huperzine A (3), huperzine A 8α,15α-epoxide (4), 13N-formyl huperzine A (5), and 13N-acetyl huperzine A (6) on the basis of their chemical and physical data.
Xinyuan Zhang, Jian-hua Zou, Jungui Dai
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Synthesis of a hybrid analog of the acetylcholinesterase inhibitors huperzine A and huperzine B

Tetrahedron Letters, 2001
Abstract The synthesis of a new hybrid analog of the acetylcholinesterase (AChE) inhibitors huperzine A and B is reported. An intramolecular reductive dicarbonyl coupling was used as a key reaction for constructing the tetracyclic ring system.
V Rajendran, Suo-Bao Rong, Ashima Saxena, Bhupendra P Doctor, Alan P Kozikowski   +4 more
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A Formal Synthesis of (+)-Huperzine A

Tetrahedron, 2000
Abstract A new formal stereoselective synthesis of (+)-Huperzine A (1) was achieved using as a key step a palladium mediated annulation between 2-methylene-1,3-propanediol diacetate and (1R,2S)-2-phenylcyclohexanol derived β-ketoester 2c.
Arnaud Haudrechy, Christophe Chassaing, Claude Riche, Yves Langlois   +3 more
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A Convergent Approach to Huperzine A and Analogues.

ChemInform, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
Seán A, Kelly, Yann, Foricher, John, Mann, Jonathan M, Bentley   +3 more
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A combination of [+] and [−]-Huperzine A improves protection against soman toxicity compared to [+]-Huperzine A in guinea pigs

Chemico-Biological Interactions, 2013
The neuropathologic mechanisms after exposure to lethal doses of nerve agent are complex and involve multiple biochemical pathways. Effective treatment requires drugs that can simultaneously protect by reversible binding to the acetylcholinesterase (AChE) and blocking cascades of seizure related brain damage, inflammation, neuronal degeneration as well
Ying, Wang, Yanling, Wei, Samuel, Oguntayo, Bhupendra P, Doctor, Madhusoodana P, Nambiar   +4 more
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A Bridgehead Enone Approach to Huperzine a

Synthetic Communications, 1992
Abstract The preparation of a bicyclic amino ketone for the synthesis of huperzine has been achieved in only six steps. The key step is the introduction of the primary amine moiety via a bridgehead enone.
George A. Kraus, Jeff Hansen, Danette Vines   +2 more
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Synthesis of 5-substituted analogues of huperzine A

Bioorganic & Medicinal Chemistry Letters, 2000
Three 5-isosteres of huperzine A (2-4) were first synthesized. The key intermediate 10 was prepared by the reaction of acid 13 with LTA. The compounds 2 and 3 had 50% inhibition by 35 and 47 microM, respectively, which still retained antiacetylcholinesterase activity.
G C, Zhou, D Y, Zhu
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