Results 121 to 130 of about 12,358,109 (167)

The First Total Synthesis of (±)-Huperzine B

The Journal of Organic Chemistry, 1997
Huperzine B, a new Lycopodium alkaloid, exhibits a memory facilitating effect in mice and may be useful as an acetylcholinesterase inhibitor for the treatment of Alzheimer's disease. An efficient synthetic approach to huperzine B has been established successfully.
Baogen Wu, Donglu Bai
openaire   +1 more source

Synthesis of Huperzine B Through Ring Closing Metathesis.

ChemInform, 2004
AbstractFor Abstract see ChemInform Abstract in Full Text.
Ihl Young Choi Lee, Joong Yeoun Hong, Myung Hee Jung, Hyo Won Lee   +3 more
openaire   +1 more source

ChemInform Abstract: Synthesis of a Hybrid Analogue (I) of the Acetylcholinesterase Inhibitors Huperzine A and Huperzine B.

ChemInform, 2001
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
V. Rajendran, Suo‐Bao Rong, Ashima Saxena, Bhupendra P. Doctor, Alan P. Kozikowski   +4 more
openaire   +1 more source

Synthesis of More Potent Analogues of the Acetylcholinesterase Inhibitor, Huperzine B.

ChemInform, 2002
AbstractFor Abstract see ChemInform Abstract in Full Text.
V, Rajendran, Ashima, Saxena, Bhupendra P, Doctor, Alan P, Kozikowski   +3 more
openaire   +2 more sources

Ginkgolide A, B, and huperzine A inhibit nitric oxide-induced neurotoxicity

International Immunopharmacology, 2002
Nitric oxide (NO) is believed to play important roles in neuronal degeneration. In this study, the effects of NO on cell growth and apoptosis have been examined in human neuroblastoma cell line SK-N-SH. Sodium nitroprusside (SNP), a NO donor, was found to significantly inhibit cell growth and to induce apoptosis. The inhibitory and apoptotic activities
Hong-Wei, Zhao, Xiao-Yu, Li
openaire   +2 more sources

Bis-huperzine B:  Highly Potent and Selective Acetylcholinesterase Inhibitors

Journal of Medicinal Chemistry, 2005
By targeting dual active sites of AChE, a series of bis-huperzine B analogues with various lengths of the tether were designed, synthesized, and tested for their inhibition and selectivity. The most potent bis-huperzine B (5g) exhibited 3900-fold increase in AChE inhibition and 930-fold greater in selectivity for AChE vs BuChE than its parent huperzine
Song, Feng, Zhifei, Wang, Xuchang, He, Suxin, Zheng, Yu, Xia, Hualiang, Jiang, Xican, Tang, Donglu, Bai   +7 more
openaire   +2 more sources

Biotransformation of Huperzine B by a Fungal Endophyte of Huperzia serrata

Chemistry & Biodiversity, 2019
AbstractThe biotransformation of huperzine B (hupB), one of the characteristic bioactive constituents of the medicinal plant Huperzia serrata, by a fungal endophyte of the host plant was studied. One new compound, 8α,15α‐epoxyhuperzine B (1), along with two known oxygenated hupB analogs, 16‐hydroxyhuperzine B (2) and carinatumin B (3), was isolated and
Zha‐Jun Zhan, Ting Tian, Yi‐Lian Xu, Hang‐Fei Yu, Cai‐Xue Zhang, Zhi‐Dong Zhang, Qi‐Yong Tang, Wei‐Guang Shan, You‐Min Ying   +8 more
openaire   +2 more sources

ChemInform Abstract: Synthetic Approaches Towards Huperzine A and B

ChemInform, 2015
AbstractReview: 44 refs.
Shariar Md. Abu Sohel, Till Opatz
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ChemInform Abstract: The First Total Synthesis of (.+‐.)‐Huperzine B.

ChemInform, 1998
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
B. WU, D. BAI
openaire   +1 more source

Simultaneously preparative purification of Huperzine A and Huperzine B from Huperzia serrata by macroporous resin and preparative high performance liquid chromatography

Journal of Chromatography B, 2012
Huperzine A (HupA) and Huperzine B (HupB) are natural alkaloids existed in Lycopodium plants. They both have potential clinical application for treating Alzheimer's Disease (AD). For the purpose of better utilizing the limited plant resources, a quick and low cost method to separate and purify HupA and HupB from Huperzia serrata (Thunb.
Hongchao, Zhang, Hao, Liang, Pengqun, Kuang, Qipeng, Yuan, Yan, Wang   +4 more
openaire   +2 more sources