Results 1 to 10 of about 47,060 (213)

Synaptic Hyaluronan Synthesis and CD44-Mediated Signaling Coordinate Neural Circuit Development

Cells, 2021
The hyaluronan-based extracellular matrix is expressed throughout nervous system development and is well-known for the formation of perineuronal nets around inhibitory interneurons.
Emily S. Wilson, Karen Litwa
doaj   +1 more source

Roles of glomerular endothelial hyaluronan in the development of proteinuria

Physiological Reports, 2021
Vascular endothelial cells are covered with glycocalyx comprising heparan sulfate, hyaluronan, chondroitin sulfate, and associated proteins. Glomerular endothelial glycocalyx is involved in protecting against induction of proteinuria and structural ...
Akimasa Asai, Naoyuki Hatayama, Keisuke Kamiya, Mai Yamauchi, Hiroshi Kinashi, Makoto Yamaguchi, Takayuki Katsuno, Hironobu Nobata, Kazushi Watanabe, Akihiko Wakatsuki, Jan Aten, Shoichi Maruyama, Takuji Ishimoto, Shuichi Hirai, Munekazu Naito, Yasuhiko Ito   +15 more
doaj   +1 more source

Targeting Hyaluronan Synthesis in Cancer: A Road Less Travelled

Biologics, 2023
Hyaluronan is one of the major components of the extracellular matrix and is involved in the regulation of multiple processes in both human physiology and disease.
Theodoros Karalis
doaj   +1 more source

CD44-mediated hyaluronan binding marks proliferating hematopoietic progenitor cells and promotes bone marrow engraftment. [PDF]

PLoS ONE, 2018
CD44 is a widely expressed cell adhesion molecule that binds to the extracellular matrix component, hyaluronan. However, this interaction is not constitutive in most immune cells at steady state, as the ability of CD44 to engage hyaluronan is highly ...
Sally S M Lee-Sayer, Meghan N Dougan, Jesse Cooper, Leslie Sanderson, Manisha Dosanjh, Christopher A Maxwell, Pauline Johnson   +6 more
doaj   +1 more source

Hyaluronan export through plasma membranes depends on concurrent K+ efflux by K(ir) channels. [PDF]

PLoS ONE, 2012
Hyaluronan is synthesized within the cytoplasm and exported into the extracellular matrix through the cell membrane of fibroblasts by the MRP5 transporter.
Daniel Hagenfeld, Beatrice Borkenhagen, Tobias Schulz, Hermann Schillers, Udo Schumacher, Peter Prehm   +5 more
doaj   +1 more source

Developing Fluorescent Hyaluronan Analogs for Hyaluronan Studies [PDF]

Molecules, 2012
Two kinds of fluorescent hyaluronan (HA) analogs, one serving as normal imaging agent and the other used as a biosensitive contrast agent, were developed for the investigation of HA uptake and degradation. Our approach of developing HA imaging agents depends on labeling HA with varying molar percentages of a near-infrared (NIR) dye.
Shi Ke, Arlin G. Cameron, Wei Wang
openaire   +3 more sources

Hyaluronan nanoscale clustering and Hyaluronan synthase 2 expression are linked to the invasion of child fibroblasts and infantile fibrosarcoma in vitro and in vivo

Scientific Reports, 2022
Infantile fibrosarcoma is a rare childhood tumour that originates in the fibrous connective tissue of the long bones for which there is an urgent need to identify novel therapeutic targets.
Joseph J. Tonge, Scott V. Notley, Mark J. Dunning, Ana López-Guajardo, Jessica D. Medcalf, Paraskevi Heldin, George Panoutsos, Annica K. B. Gad   +7 more
doaj   +1 more source

Biocompatible topical delivery system of high-molecular-weight hyaluronan into human stratum corneum using magnesium chloride

Scientific Reports, 2023
Non-invasive delivery of hyaluronan into the stratum corneum (SC) is extremely difficult because of its high molecular weight and the strong barrier of the SC.
Mika Y. Fujii, Anna Okishima, Hiroko S. Ichiwata, Takashi Oka   +3 more
doaj   +1 more source

Endogenous production of hyaluronan, PRG4, and cytokines is sensitive to cyclic loading in synoviocytes

PLoS ONE, 2022
Synovial fluid is composed of hyaluronan and proteoglycan-4 (PRG4 or lubricin), which work synergistically to maintain joint lubrication. In diseases like osteoarthritis, hyaluronan and PRG4 concentrations can be altered, resulting in lowered synovial ...
Meghana Pendyala, Paige S. Woods, Douglas K. Brubaker, Elizabeth A. Blaber, Tannin A. Schmidt, Deva D. Chan   +5 more
doaj   +2 more sources

MCF10CA Breast Cancer Cells Utilize Hyaluronan-Coated EV-Rich Trails for Coordinated Migration

Frontiers in Oncology, 2022
Invasion of tumor cells through the stroma is coordinated in response to migratory cues provided by the extracellular environment. One of the most abundant molecules in the tumor microenvironment is hyaluronan, a glycosaminoglycan known to promote many ...
Niina Aaltonen, Heikki Kyykallio, Sylvain Tollis, Janne Capra, Jaana M. Hartikainen, Johanna Matilainen, Sanna Oikari, Kirsi Rilla   +7 more
doaj   +1 more source