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Hyaluronan: Metabolism and Function
Biomolecules, 2020 As a major polysaccharide component of the extracellular matrix, hyaluronan plays essential roles in the organization of tissue architecture and the regulation of cellular functions, such as cell proliferation and migration, through interactions with ...
Takashi Kobayashi +2 more
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Gut Microbes, 2021 Hyaluronan is a glycosaminoglycan polymer that has been shown to play an important role in homeostasis of the gastrointestinal tract. However, its mechanistic significance in gastrointestinal epithelial barrier elements remain unexplored.
Tangyou Mao +8 more
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Nature Communications, 2020 Bioproduction of hyaluronan needs increases in yield and greater diversity of the molecular weights. Here, the author increases hyaluronan production and diversifies the molecular weights through engineering the hyaluronan biosynthesis pathway and ...
Yang Wang +7 more
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Chemical Modification of Hyaluronan and Their Biomedical Applications
Frontiers in Chemistry, 2022 Hyaluronan, the extracellular matrix glycosaminoglycan, is an important structural component of many tissues playing a critical role in a variety of biological contexts.
Vera Hintze +2 more
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Hyaluronan: Sources, Structure, Features and Applications
MoleculesHyaluronan (HA) is a non-sulfated glycosaminoglycan that is present in a variety of body tissues and organs. Hyaluronan has a wide range of biological activities that are frequently influenced by molar mass; however, they also depend greatly on the ...
Katarína Valachová +2 more
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Hyaluronan and Its Interactions With Immune Cells in the Healthy and Inflamed Lung
Frontiers in Immunology, 2018 Hyaluronan is a hygroscopic glycosaminoglycan that contributes to both extracellular and pericellular matrices. While the production of hyaluronan is essential for mammalian development, less is known about its interaction and function with immune cells.
Pauline Johnson +3 more
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Genetic Deficiency of Hyaluronan Synthase 2 in the Developing Limb Mesenchyme Impairs Postnatal Synovial Joint Formation [PDF]
BiomedicinesHyaluronan, a key component of the extracellular matrix, plays a crucial role in joint development and maintenance. In order to determine the role of hyaluronan function in joint development and homeostasis, conditional loss-of-function experiments of ...
Yingcui Li +10 more
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Size Matters: Molecular Weight Specificity of Hyaluronan Effects in Cell Biology
International Journal of Cell Biology, 2015 Hyaluronan signaling properties are unique among other biologically active molecules, that they are apparently not influenced by postsynthetic molecular modification, but by hyaluronan fragment size. This review summarizes the current knowledge about the
Jaime M. Cyphert +2 more
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The Content and Size of Hyaluronan in Biological Fluids and Tissues
Frontiers in Immunology, 2015 Hyaluronan is a simple repeating disaccharide polymer, synthesized at the cell surface by integral membrane synthases. The repeating sequence is perfectly homogeneous, and is the same in all vertebrate tissues and fluids.
Mary K. Cowman +4 more
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Synaptic Hyaluronan Synthesis and CD44-Mediated Signaling Coordinate Neural Circuit Development
Cells, 2021 The hyaluronan-based extracellular matrix is expressed throughout nervous system development and is well-known for the formation of perineuronal nets around inhibitory interneurons.
Emily S. Wilson, Karen Litwa
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