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Hyaluronan: Biosynthesis and signaling [PDF]
Biochimica et Biophysica Acta (BBA) - General Subjects, 2014 Background Hyaluronan is a critical component of extracellular matrix with several different roles. Besides the contribution to the tissue hydration, mechanical properties and correct architecture, hyaluronan plays important biological functions ...
De Luca, G. +5 more
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The Degradation of Hyaluronan in the Skin [PDF]
Biomolecules, 2022 Hyaluronan (HA) comprises a fundamental component of the extracellular matrix and participates in a variety of biological processes. Half of the total amount of HA in the human body is present in the skin. HA exhibits a dynamic turnover; its half-life in the skin is less than one day.
Petra Žádníková +7 more
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Developing Fluorescent Hyaluronan Analogs for Hyaluronan Studies [PDF]
Molecules, 2012 Two kinds of fluorescent hyaluronan (HA) analogs, one serving as normal imaging agent and the other used as a biosensitive contrast agent, were developed for the investigation of HA uptake and degradation. Our approach of developing HA imaging agents depends on labeling HA with varying molar percentages of a near-infrared (NIR) dye.
Wei Wang, Arlin G. Cameron, Shi Ke
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Marine Biomaterials: Hyaluronan
Marine Drugs, 2023 The marine-derived hyaluronic acid and other natural biopolymers offer exciting possibilities in the field of biomaterials, providing sustainable and biocompatible alternatives to synthetic materials. Their unique properties and abundance in marine sources make them valuable resources for various biomedical and industrial applications.
Rasha. M. Abdel-Rahman +1 more
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Hyaluronan concentration and size distribution in human knee synovial fluid: variations with age and cartilage degeneration. [PDF]
, 2016 BackgroundOne potential mechanism for early superficial cartilage wear in normal joints is alteration of the lubricant content and quality of synovial fluid.
Chen, Albert C +10 more
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Pleading Securities Fraud [PDF]
, 2001 Hyaluronan based hydrogel coatings can mimic extracellular matrix components and incorporate growth factors that can be released during a progressive degradation while new tissue regenerates.
Bergman +39 more
core +4 more sources
Diagnostic usefulness of Hyaluronan and Hyaluronan Synthases-A Review [PDF]
International Journal of Multidisciplinary and Current Research, 2018 The first isolation of HA was in the year 1934, but research on HA and its clinical significance in health and disease started only in the year 1970. Both HA and HASs play a significant role in many physiological and pathological processes. The cellular HA synthesis are coordinated collectively by HASs.
Dr.Oviya Senthilraj +3 more
openaire +3 more sources
Hyaluronan and cardiac regeneration [PDF]
Journal of Biomedical Science, 2014 Hyaluronan (HA) is abundantly expressed in several human tissues and a variety of roles for HA has been highlighted. Particularly relevant for tissue repair, HA is actively produced during tissue injury, as widely evidenced in wound healing investigations.
BONAFÈ, FRANCESCA +5 more
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Chlorination and oxidation of heparin and hyaluronan by hypochlorous acid and hypochlorite anions: effect of sulfate groups on reaction pathways and kinetics. [PDF]
, 2013 Hypochlorous acid (HOCl), produced in inflammatory conditions by the enzyme myeloperoxidase, and its anion hypochlorite (OCl(-)) exist in vivo at almost equal concentrations.
Akeel, A +4 more
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ΔNp63-mediated regulation of hyaluronic acid metabolism and signaling supports HNSCC tumorigenesis [PDF]
, 2017 Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide, and several molecular pathways that underlie the molecular tumorigenesis of HNSCC have been identified. Among them, amplification or overexpression of ΔNp63 isoforms
Anemone, Lucia +12 more
core +2 more sources