Engineering Intervertebral Disc Regeneration: Biomaterials, Cell Sources and Animal Models
Cell Proliferation, EarlyView.This review highlights the current tissue engineering approaches utilising biomaterials, animal models and cell sources for intervertebral disc regeneration and discusses future opportunities. ABSTRACT Intervertebral disc (IVD) degeneration is an age‐related problem triggering chronic spinal issues, such as low back pain and IVD herniation.
Sidong Yang +8 more
wiley +1 more source
Contribution of perineuronal nets to hyperexcitability in pilocarpine‐induced status epilepticus
Epilepsia, EarlyView.Abstract Objective Changes in extracellular matrix (ECM) and highly condensed ECM structures called perineuronal nets (PNNs) have been reported in human patients with epilepsy as well as some animal models of epilepsy. We studied potential ECM changes in a mouse model of pilocarpine‐induced status epilepticus (PISE) and their potential contributions to
AnnaLin M. Woo +3 more
wiley +1 more source
Intra-articular hyaluronan injections in the treatment of osteoarthritis of the knee: a randomised, double blind, placebo controlled multicentre trial. Hyaluronan Multicentre Trial Group. [PDF]
, 1996 Stefan Lohmander +10 more
openalex +1 more source
Equine Veterinary Journal, EarlyView.Abstract Deep digital flexor (DDF) tendinopathy is a significant cause of lameness and poor performance in equine athletes with substantial implications for their return to athletic performance. Magnetic resonance imaging (MRI) is increasingly integrated into the diagnostic workup of horses with foot pain and has revolutionised the diagnosis and ...
Alexandra Scharf +3 more
wiley +1 more source
AP-1-Mediated Invasion Requires Increased Expression of the Hyaluronan Receptor CD44 [PDF]
, 1997 Richard F. Lamb +6 more
openalex +1 more source
Equine Veterinary Journal, EarlyView.Abstract Background Synovial fluid (SF) is an ideal sentinel fluid for osteoarthritis (OA) diagnosis and prognostication due to its critical homeostatic role, proximity to articular tissues and immune cell composition. Untargeted proteomics enable identification of soluble markers for diagnostic and therapeutic applications while minimising bias ...
Erica J. Secor +4 more
wiley +1 more source
Hyaluronan biology: A complex balancing act of structure, function, location and context.
Matrix Biology, 2019 S. Garantziotis, R. Savani
semanticscholar +1 more source
Induction of IL-12 and chemokines by hyaluronan requires adhesion-dependent priming of resident but not elicited macrophages. [PDF]
, 1997 Jennifer Hodge-Dufour +8 more
openalex +1 more source
Osteochondrosis in horses: An overview of genetic and other factors
Equine Veterinary Journal, EarlyView.Abstract Osteochondrosis (OC) is a frequent manifestation of developmental orthopaedic disease, and its severe clinical presentation is known as OC dissecans (OCD). OC is defined as a disruption of the endochondral ossification process in the epiphyseal cartilage, and this disease has been reported in different mammalian species, including humans, dogs,
Lola Martinez‐Saez +2 more
wiley +1 more source