Results 11 to 20 of about 81,827 (314)
Rodlike Complexes of a Polyelectrolyte (Hyaluronan) and a Protein (Lysozyme) observed by SANS [PDF]
Biomacromolecules 12 (2012) 859-870, 2011 We study by Small Angle Neutron Scattering (SANS) the structure of Hyaluronan -Lysozyme complexes. Hyaluronan (HA) is a polysaccharide of 9 nm intrinsic persistence length that bears one negative charge per disaccharide monomer (Mmol = 401.3 g/mol); two ...
Boué, François +4 more
core +7 more sources
Stress management in composite biopolymer networks [PDF]
, 2019 Living tissues show an extraordinary adaptiveness to strain, which is crucial for their proper biological functioning. The physical origin of this mechanical behaviour has been widely investigated using reconstituted networks of collagen fibres, the ...
Burla, Federica +4 more
core +3 more sources
Synaptic Hyaluronan Synthesis and CD44-Mediated Signaling Coordinate Neural Circuit Development
Cells, 2021 The hyaluronan-based extracellular matrix is expressed throughout nervous system development and is well-known for the formation of perineuronal nets around inhibitory interneurons.
Emily S. Wilson, Karen Litwa
doaj +1 more source
Roles of glomerular endothelial hyaluronan in the development of proteinuria
Physiological Reports, 2021 Vascular endothelial cells are covered with glycocalyx comprising heparan sulfate, hyaluronan, chondroitin sulfate, and associated proteins. Glomerular endothelial glycocalyx is involved in protecting against induction of proteinuria and structural ...
Akimasa Asai +15 more
doaj +1 more source
Targeting Hyaluronan Synthesis in Cancer: A Road Less Travelled
Biologics, 2023 Hyaluronan is one of the major components of the extracellular matrix and is involved in the regulation of multiple processes in both human physiology and disease.
Theodoros Karalis
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CD44-mediated hyaluronan binding marks proliferating hematopoietic progenitor cells and promotes bone marrow engraftment. [PDF]
PLoS ONE, 2018 CD44 is a widely expressed cell adhesion molecule that binds to the extracellular matrix component, hyaluronan. However, this interaction is not constitutive in most immune cells at steady state, as the ability of CD44 to engage hyaluronan is highly ...
Sally S M Lee-Sayer +6 more
doaj +1 more source
Halting hyaluronidase activity with hyaluronan-based nanohydrogels: development of versatile injectable formulations [PDF]
Carbohydrate Polymers, 221 209-220, 2019, 2022 Hyaluronan (HA) is among the most used biopolymers for viscosupplementation and cosmetic applications. However, the current injectable HA-based formulations present relevant limitations: I) unmodified HA is quickly degraded by endogenous hyaluronidases (HAase), resulting in short lasting properties; II) cross-linked HA, although shows enhanced ...
arxiv +1 more source
Hyaluronan export through plasma membranes depends on concurrent K+ efflux by K(ir) channels. [PDF]
PLoS ONE, 2012 Hyaluronan is synthesized within the cytoplasm and exported into the extracellular matrix through the cell membrane of fibroblasts by the MRP5 transporter.
Daniel Hagenfeld +5 more
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Scientific Reports, 2022 Infantile fibrosarcoma is a rare childhood tumour that originates in the fibrous connective tissue of the long bones for which there is an urgent need to identify novel therapeutic targets.
Joseph J. Tonge +7 more
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Scientific Reports, 2023 Non-invasive delivery of hyaluronan into the stratum corneum (SC) is extremely difficult because of its high molecular weight and the strong barrier of the SC.
Mika Y. Fujii +3 more
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