Structure, substrate recognition and initiation of hyaluronan synthase
Nature, 2022 Jeremi Kuklewicz +2 more
exaly +2 more sources
Quantification of hyaluronan in human fasciae: variations with function and anatomical site [PDF]
Journal of Anatomy, 2018 Recently, alterations in fascial gliding‐like movement have been invoked as critical in the etiology of myofascial pain. Various methods have been attempted for the relief of this major and debilitating clinical problem.
Caterina Fede +7 more
openalex +2 more sources
ACS Nano, 2017 Hyaluronan is a biologically active polymer, which can be formulated into nanoparticles. In our study, we aimed to probe atherosclerosis-associated inflammation by using hyaluronan nanoparticles and to determine whether they can ameliorate ...
Max L Senders +2 more
exaly +2 more sources
Genetic Deficiency of Hyaluronan Synthase 2 in the Developing Limb Mesenchyme Impairs Postnatal Synovial Joint Formation [PDF]
BiomedicinesHyaluronan, a key component of the extracellular matrix, plays a crucial role in joint development and maintenance. In order to determine the role of hyaluronan function in joint development and homeostasis, conditional loss-of-function experiments of ...
Yingcui Li +10 more
doaj +2 more sources
Synaptic Hyaluronan Synthesis and CD44-Mediated Signaling Coordinate Neural Circuit Development
Cells, 2021 The hyaluronan-based extracellular matrix is expressed throughout nervous system development and is well-known for the formation of perineuronal nets around inhibitory interneurons.
Emily S. Wilson, Karen Litwa
doaj +1 more source
Roles of glomerular endothelial hyaluronan in the development of proteinuria
Physiological Reports, 2021 Vascular endothelial cells are covered with glycocalyx comprising heparan sulfate, hyaluronan, chondroitin sulfate, and associated proteins. Glomerular endothelial glycocalyx is involved in protecting against induction of proteinuria and structural ...
Akimasa Asai +15 more
doaj +1 more source
CD44-mediated hyaluronan binding marks proliferating hematopoietic progenitor cells and promotes bone marrow engraftment. [PDF]
PLoS ONE, 2018 CD44 is a widely expressed cell adhesion molecule that binds to the extracellular matrix component, hyaluronan. However, this interaction is not constitutive in most immune cells at steady state, as the ability of CD44 to engage hyaluronan is highly ...
Sally S M Lee-Sayer +6 more
doaj +1 more source
The Degradation of Hyaluronan in the Skin
Biomolecules, 2022 Hyaluronan (HA) comprises a fundamental component of the extracellular matrix and participates in a variety of biological processes. Half of the total amount of HA in the human body is present in the skin. HA exhibits a dynamic turnover; its half-life in
P. Zadnikova +7 more
semanticscholar +1 more source
Hyaluronan export through plasma membranes depends on concurrent K+ efflux by K(ir) channels. [PDF]
PLoS ONE, 2012 Hyaluronan is synthesized within the cytoplasm and exported into the extracellular matrix through the cell membrane of fibroblasts by the MRP5 transporter.
Daniel Hagenfeld +5 more
doaj +1 more source
Developing Fluorescent Hyaluronan Analogs for Hyaluronan Studies [PDF]
Molecules, 2012 Two kinds of fluorescent hyaluronan (HA) analogs, one serving as normal imaging agent and the other used as a biosensitive contrast agent, were developed for the investigation of HA uptake and degradation. Our approach of developing HA imaging agents depends on labeling HA with varying molar percentages of a near-infrared (NIR) dye.
Shi Ke, Arlin G. Cameron, Wei Wang
openaire +3 more sources