Results 21 to 30 of about 114,431 (323)

Hyaluronan nanoscale clustering and Hyaluronan synthase 2 expression are linked to the invasion of child fibroblasts and infantile fibrosarcoma in vitro and in vivo

Scientific Reports, 2022
Infantile fibrosarcoma is a rare childhood tumour that originates in the fibrous connective tissue of the long bones for which there is an urgent need to identify novel therapeutic targets.
Joseph J. Tonge, Scott V. Notley, Mark J. Dunning, Ana López-Guajardo, Jessica D. Medcalf, Paraskevi Heldin, George Panoutsos, Annica K. B. Gad   +7 more
doaj   +1 more source

Randomized Phase III Trial of Pegvorhyaluronidase Alfa With Nab-Paclitaxel Plus Gemcitabine for Patients With Hyaluronan-High Metastatic Pancreatic Adenocarcinoma

Journal of Clinical Oncology, 2020
PURPOSE To evaluate the efficacy and safety of pegvorhyaluronidase alfa (PEGPH20) plus nab-paclitaxel/gemcitabine (AG) in patients with hyaluronan-high metastatic pancreatic ductal adenocarcinoma (PDA).
E. Van Cutsem, M. Tempero, D. Sigal, D. Oh, N. Fazio, T. Macarulla, E. Hitre, P. Hammel, A. Hendifar, S. Bates, Chung-Pin Li, S. Hingorani, C. de la Fouchardière, A. Kasi, V. Heinemann, A. Maraveyas, N. Bahary, L. Layos, V. Sahai, Lei Zheng, J. Lacy, Joon-Oh Park, F. Portales, P. Oberstein, Wilson Wu, D. Chondros, A. Bullock   +26 more
semanticscholar   +1 more source

Hyaluronan and the Fascial Frontier

International Journal of Molecular Sciences, 2021
The buzz about hyaluronan (HA) is real. Whether found in face cream to increase water volume loss and viscoelasticity or injected into the knee to restore the properties of synovial fluid, the impact of HA can be recognized in many disciplines from ...
Rebecca L Pratt
semanticscholar   +1 more source

Biocompatible topical delivery system of high-molecular-weight hyaluronan into human stratum corneum using magnesium chloride

Scientific Reports, 2023
Non-invasive delivery of hyaluronan into the stratum corneum (SC) is extremely difficult because of its high molecular weight and the strong barrier of the SC.
Mika Y. Fujii, Anna Okishima, Hiroko S. Ichiwata, Takashi Oka   +3 more
doaj   +1 more source

MCF10CA Breast Cancer Cells Utilize Hyaluronan-Coated EV-Rich Trails for Coordinated Migration

Frontiers in Oncology, 2022
Invasion of tumor cells through the stroma is coordinated in response to migratory cues provided by the extracellular environment. One of the most abundant molecules in the tumor microenvironment is hyaluronan, a glycosaminoglycan known to promote many ...
Niina Aaltonen, Heikki Kyykallio, Sylvain Tollis, Janne Capra, Jaana M. Hartikainen, Johanna Matilainen, Sanna Oikari, Kirsi Rilla   +7 more
doaj   +1 more source

Endogenous production of hyaluronan, PRG4, and cytokines is sensitive to cyclic loading in synoviocytes

PLoS ONE, 2022
Synovial fluid is composed of hyaluronan and proteoglycan-4 (PRG4 or lubricin), which work synergistically to maintain joint lubrication. In diseases like osteoarthritis, hyaluronan and PRG4 concentrations can be altered, resulting in lowered synovial ...
Meghana Pendyala, Paige S. Woods, Douglas K. Brubaker, Elizabeth A. Blaber, Tannin A. Schmidt, Deva D. Chan   +5 more
doaj   +2 more sources

Pleading Securities Fraud [PDF]

, 2001
Hyaluronan based hydrogel coatings can mimic extracellular matrix components and incorporate growth factors that can be released during a progressive degradation while new tissue regenerates.
Bergman, Berts, Best, Buddula, Chiba, Ciccone, Cubitt, Feiler, Fraser, Golub, Haxaire, Hench, Heymann, Hulsart-Billström, Hunziker, Höök, Kang, Katzer, Liu, Martinez-Sanz, Martínez-Sanz, Morra, Navarro, Nayab, Park, Patterson, Piskounova, Polunina, Sauerbrey, Scheufler, Serro, Vasikaran, Voinova, Voinova, Wozney, Yamanlar, Yang, Yoshinari, Zara, Åberg   +39 more
core   +4 more sources

The where, when, how and why of hyaluronan binding by immune cells

Frontiers in Immunology, 2015
Hyaluronan is made and extruded from cells to form a pericellular or extracellular matrix (ECM) and is present in virtually all tissues in the body. The size and form of hyaluronan present in tissues is indicative of a healthy or inflamed tissue, and the
Sally S. M. Lee-Sayer, Yifei eDong, Arif A Arif, Mia eOlsson, Kelly L Brown, Pauline eJohnson   +5 more
doaj   +1 more source

Hyaluronan concentration and size distribution in human knee synovial fluid: variations with age and cartilage degeneration. [PDF]

, 2016
BackgroundOne potential mechanism for early superficial cartilage wear in normal joints is alteration of the lubricant content and quality of synovial fluid.
Chen, Albert C, D'Lima, Darryl D, Hansen, Bradley C, Hasegawa, Akihiko, Koziol, Jim, Lotz, Martin K, Masuda, Koichi, Quach, Phu, Ren, Shuwen, Sah, Robert L, Temple-Wong, Michele M   +10 more
core   +1 more source

Mycobacteria exploit host hyaluronan for efficient extracellular replication. [PDF]

PLoS Pathogens, 2009
In spite of the importance of hyaluronan in host protection against infectious organisms in the alveolar spaces, its role in mycobacterial infection is unknown.
Yukio Hirayama, Mamiko Yoshimura, Yuriko Ozeki, Isamu Sugawara, Tadashi Udagawa, Satoru Mizuno, Naoki Itano, Koji Kimata, Aki Tamaru, Hisashi Ogura, Kazuo Kobayashi, Sohkichi Matsumoto   +11 more
doaj   +1 more source