Results 21 to 30 of about 81,827 (314)

Molecular dynamics simulations of the affinity of chitin and chitosan for collagen: the effect of pH and the presence of sodium and calcium cations [PDF]

Progress on Chemistry and Application of Chitin and Its Derivatives 28 (2023): 136-50, 2023
Chitosan and chitin are promising biopolymers used in many areas including biomedical applications, such as tissue engineering and viscosupplementation. Chitosan shares similar properties with hyaluronan, a natural component of synovial fluid, making it a good candidate for joint disease treatment.
arxiv   +1 more source

Endogenous production of hyaluronan, PRG4, and cytokines is sensitive to cyclic loading in synoviocytes.

PLoS ONE, 2022
Synovial fluid is composed of hyaluronan and proteoglycan-4 (PRG4 or lubricin), which work synergistically to maintain joint lubrication. In diseases like osteoarthritis, hyaluronan and PRG4 concentrations can be altered, resulting in lowered synovial ...
Meghana Pendyala, Paige S Woods, Douglas K Brubaker, Elizabeth A Blaber, Tannin A Schmidt, Deva D Chan   +5 more
doaj   +2 more sources

MCF10CA Breast Cancer Cells Utilize Hyaluronan-Coated EV-Rich Trails for Coordinated Migration

Frontiers in Oncology, 2022
Invasion of tumor cells through the stroma is coordinated in response to migratory cues provided by the extracellular environment. One of the most abundant molecules in the tumor microenvironment is hyaluronan, a glycosaminoglycan known to promote many ...
Niina Aaltonen, Heikki Kyykallio, Sylvain Tollis, Janne Capra, Jaana M. Hartikainen, Johanna Matilainen, Sanna Oikari, Kirsi Rilla   +7 more
doaj   +1 more source

The where, when, how and why of hyaluronan binding by immune cells

Frontiers in Immunology, 2015
Hyaluronan is made and extruded from cells to form a pericellular or extracellular matrix (ECM) and is present in virtually all tissues in the body. The size and form of hyaluronan present in tissues is indicative of a healthy or inflamed tissue, and the
Sally S. M. Lee-Sayer, Yifei eDong, Arif A Arif, Mia eOlsson, Kelly L Brown, Pauline eJohnson   +5 more
doaj   +1 more source

Hyaluronan: Metabolism and Function

Biomolecules, 2020
As a major polysaccharide component of the extracellular matrix, hyaluronan plays essential roles in the organization of tissue architecture and the regulation of cellular functions, such as cell proliferation and migration, through interactions with ...
Takashi Kobayashi, Theerawut Chanmee, Naoki Itano   +2 more
doaj   +1 more source

Mycobacteria exploit host hyaluronan for efficient extracellular replication. [PDF]

PLoS Pathogens, 2009
In spite of the importance of hyaluronan in host protection against infectious organisms in the alveolar spaces, its role in mycobacterial infection is unknown.
Yukio Hirayama, Mamiko Yoshimura, Yuriko Ozeki, Isamu Sugawara, Tadashi Udagawa, Satoru Mizuno, Naoki Itano, Koji Kimata, Aki Tamaru, Hisashi Ogura, Kazuo Kobayashi, Sohkichi Matsumoto   +11 more
doaj   +1 more source

Eliminating the capsule-like layer to promote glucose uptake for hyaluronan production by engineered Corynebacterium glutamicum

Nature Communications, 2020
Bioproduction of hyaluronan needs increases in yield and greater diversity of the molecular weights. Here, the author increases hyaluronan production and diversifies the molecular weights through engineering the hyaluronan biosynthesis pathway and ...
Yang Wang, Litao Hu, Hao Huang, Hao Wang, Tianmeng Zhang, Jian Chen, Guocheng Du, Zhen Kang   +7 more
doaj   +1 more source

Shock Induced Damage Mechanism Of Perineuronal Net [PDF]

, 2021
ECM components, such as the Perineuronal net (PNN), one of the most prevalent parts surrounding the neuronal cell. PNN is a protective net-like structure regulating neuronal activity such as neurotransmission, charge balance and generates an action potential. Shock induced damage of this essential component may cause neuronal cell death and potentially
arxiv   +1 more source

ALK1 controls hepatic vessel formation, angiodiversity, and angiocrine functions in hereditary hemorrhagic telangiectasia of the liver

Hepatology, EarlyView., 2022
Hepatic endothelial Alk1 signaling protects from development of vascular malformations while maintaining organ‐specific endothelial differentiation and angiocrine portmanteau of the names Wingless and Int‐1 signaling. Abstract Background and Aims In hereditary hemorrhagic telangiectasia (HHT), severe liver vascular malformations are associated with ...
Christian David Schmid, Victor Olsavszky, Manuel Reinhart, Vanessa Weyer, Felix A. Trogisch, Carsten Sticht, Manuel Winkler, Sina W. Kürschner, Johannes Hoffmann, Roxana Ola, Theresa Staniczek, Joerg Heineke, Beate K. Straub, Jens Mittler, Kai Schledzewski, Peter ten Dijke, Karsten Richter, Steven Dooley, Cyrill Géraud, Sergij Goerdt, Philipp‐Sebastian Koch   +20 more
wiley   +1 more source

Importance of hyaluronan biosynthesis and degradation in cell differentiation and tumor formation

Brazilian Journal of Medical and Biological Research, 2003
Hyaluronan is an important connective tissue glycosaminoglycan. Elevated hyaluronan biosynthesis is a common feature during tissue remodeling under both physiological and pathological conditions.
P. Heldin
doaj   +1 more source