Results 61 to 70 of about 81,827 (314)

The Impact of Hyaluronan on Tumor Progression in Cutaneous Melanoma

Frontiers in Oncology, 2022
The incidence of cutaneous melanoma is rapidly increasing worldwide. Cutaneous melanoma is an aggressive type of skin cancer, which originates from malignant transformation of pigment producing melanocytes.
Piia Takabe, Hanna Siiskonen, Aino Rönkä, Kirsi Kainulainen, Sanna Pasonen-Seppänen   +4 more
doaj   +1 more source

Bidirectional allostery mechanism of catch-bond effect in cell adhesion [PDF]

arXiv, 2023
Catch-bonds, whereby noncovalent ligand-receptor interactions are counterintuitively reinforced by tensile forces, play a major role in cell adhesion under mechanical stress. A basic prerequisite for catch-bond formation is that force-induced remodeling of ligand binding interface occurs prior to bond rupture.
arxiv  

Biphasic Granular Bioinks for Biofabrication of High Cell Density Constructs for Dermal Regeneration

Advanced Healthcare Materials, EarlyView.
This study introduces a biphasic granular bioink (µInk) that enables 3D bioprinting of high cell density constructs for dermal regeneration. The bioink promotes cell proliferation, ECM deposition, and neovascularization, leading to tissue integration and reduced scar formation in vivo.
Rozalin Shamasha, Sneha Kollenchery Ramanathan, Kristin Oskarsdotter, Fatemeh Rasti Boroojeni, Aleksandra Zielińska, Sajjad Naeimipour, Philip Lifwergren, Nina Reustle, Lauren Roberts, Annika Starkenberg, Gunnar Kratz, Peter Apelgren, Karin Säljö, Jonathan Rakar, Lars Kölby, Daniel Aili, Johan Junker   +16 more
wiley   +1 more source

Hyaluronan Does Not Affect Bupivacaine’s Inhibitory Action on Voltage-Gated Potassium Channel Activities in Bovine Articular Chondrocytes

Advances in Orthopedics, 2012
Objectives. The objective of this paper is to determine if hyaluronan affects bupivacaine’s anesthetic function. Methods. Whole cell patch clamp recordings were performed on bovine articular chondrocytes cultured in 60 mm dishes.
William Hester, Jinnan Yang, Guo-Yong Wang, Sen Liu, Michael J. O'Brien, Felix H. Savoie, Zongbing You   +6 more
doaj   +1 more source

Hydrocellular foam dressing promotes wound healing along with increases in hyaluronan synthase 3 and PPARα gene expression in epidermis. [PDF]

PLoS ONE, 2013
BackgroundHydrocellular foam dressing, modern wound dressing, induces moist wound environment and promotes wound healing: however, the regulatory mechanisms responsible for these effects are poorly understood. This study was aimed to reveal the effect of
Takumi Yamane, Gojiro Nakagami, Sawako Yoshino, Aimi Muramatsu, Sho Matsui, Yuichi Oishi, Toshiki Kanazawa, Takeo Minematsu, Hiromi Sanada   +8 more
doaj   +1 more source

Atomic-Resolution Experimental Structural Biology and Molecular Dynamics Simulations of Hyaluronan and Its Complexes

Molecules, 2022
This review summarizes the atomic-resolution structural biology of hyaluronan and its complexes available in the Protein Data Bank, as well as published studies of atomic-resolution explicit-solvent molecular dynamics simulations on these and other ...
Olgun Guvench
doaj   +1 more source

Ultrasonic and Densitometric Characterization of Hyaluronan and its Interaction with Surfactant [PDF]

, 2014
This disertation thesis is focused on the study of physico-chemical interactions of hyaluronan (with molecular weights from 10 to 1750 kDa) with cationic surfactants measured using uncommon technique named high resolution ultrasonic spectroscopy ...
Hurčíková, Andrea
core  

Hydrogel‐Mediated Preservation of Live Tumor Explants for Drug Development in Peritoneal Metastases

Advanced Materials, EarlyView.
This study presents a hyaluronan‐based hydrogel platform preserving the native tumor microenvironment (morphology, tissue composition, histology) of patient‐derived explants from peritoneal metastases, enabling clinically relevant drug screening. Hydrogel properties such as stiffness and degradation are crucial for longer‐term histoculture.
Kenny Zhuoran Wu, Rockie Haiyao Ding, Zixuan Zhao, Clara Yieh Lin Chong, Ruochii You, Hengjia Zhou, Dong Hua Seah, Wei Qiang Leow, Hong Kit Lim, Sukanya Shyamasundar, Kanishka Fernando, Fathima Farzana Kuthubudeen, Gillian Ng, Chor Yong Tay, Narayanan Gopalakrishna Iyer, Chin‐Ann Johnny Ong, Eliza Li Shan Fong   +16 more
wiley   +1 more source

HIV infection is associated with elevated biomarkers of immune activation in Ugandan adults with pneumonia. [PDF]

, 2019
IntroductionPneumonia is an important cause of morbidity and mortality in persons living with human immunodeficiency virus (HIV) infection. How immune activation differs among HIV-infected and HIV-uninfected adults with pneumonia is unknown.MethodsThe ...
Byanyima, Patrick, Chang, Emily G, Crothers, Kristina, Davis, J Lucian, Huang, Laurence, Hunt, Peter W, Kaswabuli, Sylvia, Lalitha, Rejani, Lederman, Michael M, Lin, Jue, Moisi, Daniela, Moore, Julia, Musisi, Emmanuel, Sanyu, Ingvar, Sessolo, Abdulwahab, Wang, Richard J, Worodria, William   +16 more
core   +2 more sources

Mussel‐Inspired Molecular Strategies for Fabricating Functional Materials With Underwater Adhesion and Self‐Healing Properties

Advanced Materials, EarlyView.
This review systematically examines the nanomechanical mechanisms of mussel‐inspired molecular interactions, primarily investigated by direct force measurement techniques such as surface forces apparatus and atomic force microscopy. The macroscopic adhesive and self‐healing performances of mussel‐inspired functional materials, including coacervates ...
Pan Huang, Hongjian Zhang, Hongbo Zeng
wiley   +1 more source