Hyaluronan Receptors as Mediators and Modulators of the Tumor Microenvironment. [PDF]
Adv Healthc Mater, 2023 AbstractThe tumor microenvironment (TME) is a dynamic and complex matter shaped by heterogenous cancer and cancer‐associated cells present at the tumor site. Hyaluronan (HA) is a major TME component that plays pro‐tumorigenic and carcinogenic functions.
Carvalho AM, Reis RL, Pashkuleva I.
europepmc +6 more sources
In Vivo Molecular Optical Coherence Tomography of Lymphatic Vessel Endothelial Hyaluronan Receptors [PDF]
Scientific Reports, 2017 Optical Coherence Tomography (OCT) imaging of living subjects offers increased depth of penetration while maintaining high spatial resolution when compared to other optical microscopy techniques.
Peng Si +7 more
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Hyaluronan Mediated Motility Receptor (HMMR) Encodes an Evolutionarily Conserved Homeostasis, Mitosis, and Meiosis Regulator Rather than a Hyaluronan Receptor [PDF]
Cells, 2020 Hyaluronan is an extracellular matrix component that absorbs water in tissues and engages cell surface receptors, like Cluster of Differentiation 44 (CD44), to promote cellular growth and movement.
Zhengcheng He +3 more
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Matrix: a complex amalgam of structures and functions in tumor microenvironment [PDF]
FEBS Open BioCancer cells surrounded by a rich diversity of nonmalignant cell types are collectively embedded in the matrix, which is a dynamic, intricate three‐dimensional mesh of biomolecules with both structural and functional properties.
Spyros S. Skandalis +3 more
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Role of hyaluronan in endometrial receptivity: key insights for implantation and reproductive success [PDF]
Reproductive Biology and EndocrinologyInfertility affects millions worldwide, and implantation failure remains a critical barrier in assisted reproduction. Endometrial receptivity, a fundamental prerequisite for successful implantation, involves precise regulation of extracellular matrix ...
Eva Krivakova +6 more
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Effective Cryopreservation of Post Mortem-Collected Roe Deer Gametes by Evaluation of Post-Thaw Oocyte and Sperm Characteristics and In Vitro Fertilization [PDF]
AnimalsThe aim was to evaluate the effectiveness of semen cryopreservation and oocyte vitrification in roe deer as a potential method of gamete preservation for endangered deer species.
Anna Justyna Korzekwa +5 more
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A Novel Role of Hyaluronan and Its Membrane Receptors, CD44 and RHAMM, in Obesity-Related Kidney Pathology [PDF]
BiomoleculesObesity-related kidney pathology (ORKP) is a major global issue that contributes to diabetic nephropathy and kidney cancer and leads to chronic/end-stage kidney disease.
Bingxue Qi +14 more
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Frontiers in Immunology, 2015 The glycosaminoglycan hyaluronan (HA), a major component of extracellular matrices (ECMs), and cell surface receptors of HA have been proposed to have pivotal roles in cell proliferation, migration, and invasion, which are necessary for inflammation and ...
SUNITI eMISRA +3 more
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Knock-down of CD44 regulates endothelial cell differentiation via NFκB-mediated chemokine production. [PDF]
PLoS ONE, 2014 A striking feature of microvascular endothelial cells is their capacity to fuse and differentiate into tubular structures when grown in three-dimensional (3D) extracellular matrices, in collagen or Matrigel, mimicking the in vivo blood vessel formation ...
Berit Olofsson +2 more
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Hyaluronan: Metabolism and Function
Biomolecules, 2020 As a major polysaccharide component of the extracellular matrix, hyaluronan plays essential roles in the organization of tissue architecture and the regulation of cellular functions, such as cell proliferation and migration, through interactions with ...
Takashi Kobayashi +2 more
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