Hyaluronan Receptors as Mediators and Modulators of the Tumor Microenvironment. [PDF]
Adv Healthc Mater, 2023 The tumor microenvironment (TME) is a dynamic and complex matter shaped by heterogenous cancer and cancer‐associated cells present at the tumor site. Hyaluronan (HA) is a major TME component that plays pro‐tumorigenic and carcinogenic functions.
Carvalho AM, Reis RL, Pashkuleva I.
europepmc +5 more sources
Diverse Roles for Hyaluronan and Hyaluronan Receptors in the Developing and Adult Nervous System. [PDF]
Int J Mol Sci, 2020 Hyaluronic acid (HA) plays a vital role in the extracellular matrix of neural tissues. Originally thought to hydrate tissues and provide mechanical support, it is now clear that HA is also a complex signaling molecule that can regulate cell processes in ...
Peters A, Sherman LS.
europepmc +5 more sources
Hyaluronan Mediated Motility Receptor (HMMR) Encodes an Evolutionarily Conserved Homeostasis, Mitosis, and Meiosis Regulator Rather than a Hyaluronan Receptor [PDF]
Cells, 2020 Hyaluronan is an extracellular matrix component that absorbs water in tissues and engages cell surface receptors, like Cluster of Differentiation 44 (CD44), to promote cellular growth and movement.
Zhengcheng He +3 more
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Structure and unusual binding mechanism of the hyaluronan receptor LYVE-1 mediating leucocyte entry to lymphatics [PDF]
Nature CommunicationsImmune surveillance involves the continual migration of antigen-scavenging immune cells from the tissues to downstream lymph nodes via lymphatic vessels.
Fouzia Bano +11 more
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Identification of the Hyaluronan Receptor for Endocytosis (HARE) [PDF]
Journal of Biological Chemistry, 2000 Rat liver sinusoidal endothelial cells (LECs) express two hyaluronan (HA) receptors, of 175 and 300 kDa, responsible for the endocytic clearance of HA. We have characterized eight monoclonal antibodies (mAbs) raised against the 175-kDa HA receptor partially purified from rat LECs. These mAbs also cross-react with the 300-kDa HA receptor. The 175-kDa HA
Bin Zhou +3 more
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Hyaluronan: Metabolism and Function
Biomolecules, 2020 As a major polysaccharide component of the extracellular matrix, hyaluronan plays essential roles in the organization of tissue architecture and the regulation of cellular functions, such as cell proliferation and migration, through interactions with ...
Takashi Kobayashi +2 more
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Hyaluronan receptors involved in cytokine induction in monocytes. [PDF]
Glycobiology, 2008 During inflammation, lower molecular weight fragments of hyaluronan accumulate, and this is known to be inflammatory and immune-stimulatory. In diseases such as inflammatory bowel disease, inflammatory cells bind to hyaluronan; however, the cellular ...
H. Yamawaki +9 more
semanticscholar +4 more sources
Hyaluronan and Its Receptors as Regulatory Molecules of the Endothelial Interface [PDF]
Journal of Histochemistry & Cytochemistry, 2020 On the surface of endothelial cells (ECs) lies the glycocalyx, a barrier of polysaccharides that isolates the ECs from the blood. The role of the glycocalyx is dynamic and complex, thanks to not only its structure, but its vast number of components, one ...
Kimberly Queisser +2 more
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In Vivo Molecular Optical Coherence Tomography of Lymphatic Vessel Endothelial Hyaluronan Receptors [PDF]
Scientific Reports, 2017 Optical Coherence Tomography (OCT) imaging of living subjects offers increased depth of penetration while maintaining high spatial resolution when compared to other optical microscopy techniques.
Peng Si +7 more
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Cells, 2021 Entry to the afferent lymphatics marks the first committed step for immune cell migration from tissues to draining lymph nodes both for the generation of immune responses and for timely resolution of tissue inflammation.
Louise A. Johnson, David G. Jackson
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