Results 11 to 20 of about 27,059 (274)

Diverse Roles for Hyaluronan and Hyaluronan Receptors in the Developing and Adult Nervous System. [PDF]

Int J Mol Sci, 2020
Hyaluronic acid (HA) plays a vital role in the extracellular matrix of neural tissues. Originally thought to hydrate tissues and provide mechanical support, it is now clear that HA is also a complex signaling molecule that can regulate cell processes in the developing and adult nervous systems.
Peters A, Sherman LS.
europepmc   +4 more sources

Localization of CD44 (Hyaluronan Receptor) and Hyaluronan in Rat Mandibular Condyle [PDF]

Journal of Histochemistry & Cytochemistry, 2005
CD44 is a multifunctional adhesion molecule that binds to hyaluronan (HA), type I collagen, and fibronectin. We investigated localization of CD44 and HA in mandibular condylar cartilage compared with the growth plate and the articular cartilage, to clarify the characteristics of chondrocytes.
Hiroaki, Nakamura, Ryoko, Kato, Azumi, Hirata, Miho, Inoue, Toshio, Yamamoto   +4 more
openaire   +3 more sources

TGF-beta 1 stimulation of cell locomotion utilizes the hyaluronan receptor RHAMM and hyaluronan. [PDF]

The Journal of cell biology, 1993
TGF-beta is a potent stimulator of motility in a variety of cell types. It has recently been shown that hyaluronan (HA) can directly promote locomotion of cells through interaction with the HA receptor RHAMM. We have investigated the role of RHAMM and HA in TGF-beta-stimulated locomotion and show that TGF-beta triggers the transcription, synthesis and ...
Shanti K. Samuel, Robert A. R. Hurta, M.A. Spearman, James R. Wright, Eva A. Turley, Harry B. Greenberg   +5 more
openalex   +3 more sources

Identification of the Hyaluronan Receptor for Endocytosis (HARE) [PDF]

Journal of Biological Chemistry, 2000
Rat liver sinusoidal endothelial cells (LECs) express two hyaluronan (HA) receptors, of 175 and 300 kDa, responsible for the endocytic clearance of HA. We have characterized eight monoclonal antibodies (mAbs) raised against the 175-kDa HA receptor partially purified from rat LECs. These mAbs also cross-react with the 300-kDa HA receptor. The 175-kDa HA
Bin Zhou, Janet A. Weigel, LeAnn Fauss, Paul H. Weigel   +3 more
openalex   +4 more sources

Selective adhesion inhibition and hyaluronan envelope reduction of dermal tumor cells by cold plasma-activated medium

Cell Adhesion & Migration, 2023
The sensitivity to cold plasma is specific to tumor cells while leaving normal tissue cells unaffected. This is the desired challenge in cancer therapy. Therefore, the focus of this work was a comparative study concerning the plasma sensitivity of dermal
Anna-Christin Golz, Claudia Bergemann, Finja Hildebrandt, Steffen Emmert, Barbara Nebe, Henrike Rebl   +5 more
doaj   +1 more source

Identification of two hyaluronan-binding domains in the hyaluronan receptor RHAMM.

Journal of Biological Chemistry, 1993
We have identified two discrete hyaluronan- (HA) binding domains in the HA receptor RHAMM (Receptor for HA-Mediated Motility) that mediates the locomotion of H-ras transformed fibroblasts. A complete RHAMM cDNA (1.43 kilobases (kb)) was expressed as a fusion protein with pGEX-2T in Escherichia coli HB101 and was shown to bind specifically to both ...
Bo Yang, Li Zhang, Eva A. Turley
openalex   +3 more sources

The inflammatory oxidant peroxynitrous acid modulates the structure and function of the recombinant human V3 isoform of the extracellular matrix proteoglycan versican

Redox Biology, 2023
Continued oxidant production during chronic inflammation generates host tissue damage, with this being associated with pathologies including atherosclerosis.
Sara M. Jørgensen, Lasse G. Lorentzen, Astrid Hammer, Gerald Hoefler, Ernst Malle, Christine Y. Chuang, Michael J. Davies   +6 more
doaj   +1 more source

TLR5 participates in the TLR4 receptor complex and promotes MyD88-dependent signaling in environmental lung injury

eLife, 2020
Lung disease causes significant morbidity and mortality, and is exacerbated by environmental injury, for example through lipopolysaccharide (LPS) or ozone (O3). Toll-like receptors (TLRs) orchestrate immune responses to injury by recognizing pathogen- or
Salik Hussain, Collin G Johnson, Joseph Sciurba, Xianglin Meng, Vandy P Stober, Caini Liu, Jaime M Cyphert-Daly, Katarzyna Bulek, Wen Qian, Alma Solis, Yosuke Sakamachi, Carol S Trempus, Jim J Aloor, Kym M Gowdy, W Michael Foster, John W Hollingsworth, Robert M Tighe, Xiaoxia Li, Michael B Fessler, Stavros Garantziotis   +19 more
doaj   +1 more source

Ovarian Cancer-Cell Pericellular Hyaluronan Deposition Negatively Impacts Prognosis of Ovarian Cancer Patients

Biomedicines, 2022
Background: Hyaluronan (HA), a component of the extracellular matrix, is frequently increased under pathological conditions including cancer. Not only stroma cells but also cancer cells themselves synthesize HA, and the interaction of HA with its cognate
Leticia Oliveira-Ferrer, Barbara Schmalfeldt, Johannes Dietl, Catharina Bartmann, Udo Schumacher, Christine Stürken   +5 more
doaj   +1 more source

Lipid raft-mediated regulation of hyaluronan-CD44 interactions in inflammation and cancer

Frontiers in Immunology, 2015
Hyaluronan is a major component of the extracellular matrix and plays pivotal roles in inflammation and cancer. Hyaluronan oligomers are frequently found in these pathological conditions, in which they exert their effects via association with the ...
Toshiyuki eMurai
doaj   +1 more source