Results 11 to 20 of about 2,309,824 (325)

Dissecting the Dual Nature of Hyaluronan in the Tumor Microenvironment

Frontiers in Immunology, 2019
Hyaluronan (HA) is a glycosaminoglycan with a simple structure but diverse and often opposing functions. The biological activities of this polysaccharide depend on its molecular weight and the identity of interacting receptors.
Muhan Liu, Cornelia Tolg, Eva Turley, Eva Turley   +3 more
doaj   +2 more sources

Hyaluronidase-induced matrix remodeling contributes to long-term synaptic changes [PDF]

Frontiers in Neural Circuits
Extracellular brain space contains water, dissolved ions, and multiple other signaling molecules. The neural extracellular matrix (ECM) is also a significant component of the extracellular space.
Rostislav Sokolov, Rostislav Sokolov, Viktoriya Krut', Viktoriya Krut', Vsevolod Belousov, Vsevolod Belousov, Vsevolod Belousov, Vsevolod Belousov, Andrey Rozov, Andrey Rozov, Irina V. Mukhina, Irina V. Mukhina   +11 more
doaj   +2 more sources

The Hyaluronan Receptors CD44 and Rhamm (CD168) Form Complexes with ERK1,2 That Sustain High Basal Motility in Breast Cancer Cells

Journal of Biological Chemistry, 2007
CD44 is an integral hyaluronan receptor that can promote or inhibit motogenic signaling in tumor cells. Rhamm is a nonintegral cell surface hyaluronan receptor (CD168) and intracellular protein that promotes cell motility in culture.
Sara R. Hamilton, Shireen F. Fard, Frouz Frozan Paiwand, Cornelia Tölg, Mandana Veiseh, Chao Wang, James B. McCarthy, Mina J. Bissell, James Koropatnick, Eva A. Turley   +9 more
openalex   +2 more sources

Expression of Hyaluronan Synthases and Corresponding Hyaluronan Receptors Is Differentially Regulated During Oocyte Maturation in Cattle1 [PDF]

Biology of Reproduction, 2003
In response to the gonadotropin surge, the compact cumulus-oocyte complex (COC) undergoes expansion by synthesis of the mucopolysaccharide hyaluronan (HA) accompanying oocyte maturation. The objective of the present study was to quantify mRNA transcripts of the HA synthase (HAS) 1, HAS2, and HAS3 and the HA-receptors CD44 and RHAMM (receptor for HA ...
M. Schoenfelder, R. Einspanier
semanticscholar   +4 more sources

The Content and Size of Hyaluronan in Biological Fluids and Tissues

Frontiers in Immunology, 2015
Hyaluronan is a simple repeating disaccharide polymer, synthesized at the cell surface by integral membrane synthases. The repeating sequence is perfectly homogeneous, and is the same in all vertebrate tissues and fluids.
Mary K. Cowman, Hong-Gee eLee, Kathryn L. Schwertfeger, James B. McCarthy, Eva A. Turley   +4 more
doaj   +2 more sources

INTERACTIONS BETWEEN HYALURONAN AND ITS RECEPTORS (CD44, RHAMM) REGULATE THE ACTIVITIES OF INFLAMMATION AND CANCER

Frontiers in Immunology, 2015
The glycosaminoglycan hyaluronan (HA), a major component of extracellular matrices (ECMs), and cell surface receptors of HA have been proposed to have pivotal roles in cell proliferation, migration, and invasion, which are necessary for inflammation and ...
SUNITI eMISRA, Roger R. Markwald, Vincent C. Hascall, Shibnath eGhatak   +3 more
doaj   +2 more sources

HIV infection is associated with elevated biomarkers of immune activation in Ugandan adults with pneumonia. [PDF]

PLoS ONE, 2019
IntroductionPneumonia is an important cause of morbidity and mortality in persons living with human immunodeficiency virus (HIV) infection. How immune activation differs among HIV-infected and HIV-uninfected adults with pneumonia is unknown.MethodsThe ...
Richard J Wang, Julia Moore, Daniela Moisi, Emily G Chang, Patrick Byanyima, Sylvia Kaswabuli, Emmanuel Musisi, Ingvar Sanyu, Abdulwahab Sessolo, Rejani Lalitha, William Worodria, J Lucian Davis, Kristina Crothers, Jue Lin, Michael M Lederman, Peter W Hunt, Laurence Huang   +16 more
doaj   +3 more sources

Functional Hierarchy of Simultaneously Expressed Adhesion Receptors: Integrin α2β1 but Not CD44 Mediates MV3 Melanoma Cell Migration and Matrix Reorganization within Three-dimensional Hyaluronan-containing Collagen Matrices

Molecular Biology of the Cell, 1999
Haptokinetic cell migration across surfaces is mediated by adhesion receptors including beta1 integrins and CD44 providing adhesion to extracellular matrix (ECM) ligands such as collagen and hyaluronan (HA), respectively.
Kerstin Maaser, Katarina Wolf, Christophe Klein, Bernd Niggemann, Kurt S. Zänker, Eva‐B. Bröcker, Peter Friedl   +6 more
openalex   +3 more sources

Are hyaluronan receptors involved in three-dimensional cell migration?

Histology and histopathology, 2000
Hyaluronan (HA), an unbranched polysaccharide consisting of repeated glucuronic acid/N-acetylglucosamine disaccharide units, is ubiquitously present in the extracellular matrix of many tissues (for a more comprehensive review see: Fraser et al., 1997 ...
Volker Nehls, W. Hayen
semanticscholar   +5 more sources

Sperm Separation and Selection Techniques to Mitigate Sperm DNA Damage [PDF]

Life
Semen preparation and sperm selection techniques exploit the morphological and physiological characteristics of sperm function, including motility, morphology, density, and maturity, as reflected by their cell-surface charge and the expression of ...
Steven Fleming, David Morroll, Martine Nijs   +2 more
doaj   +2 more sources