Results 241 to 250 of about 27,059 (274)

Study of Hyaluronan-Binding Proteins and Receptors Using Iodinated Hyaluronan Derivatives

2003
This chapter detailed methodology for the purification of high molecular weight HA, as well as procedures to fragment the HA to prepare large oligosaccharides in the range of 40,000-80,000 Da. The aforementioned procedures used to prepare HA-alkylamine and HA-Bolton-Hunter adducts, as well as 125I-labeled HA, have been very reproducible, and the latter
Carl T, McGary, Janet A, Weigel, Paul H, Weigel   +2 more
openaire   +2 more sources

Calcium‐Sensing Receptor function regulation by hyaluronan

The FASEB Journal, 2020
Mice exposure to halogens, chlorine (Cl 2 ) or bromine (Br 2 ), develop increased airway resistance and airway hyper‐responsiveness (AHR) to methacholine, which lasted for at least one‐week post ...
Ahmed Lazrak, Zhihong Yu, Sadis Matalon
openaire   +1 more source

Internalization of the Hyaluronan Receptor CD44 by Chondrocytes

Experimental Cell Research, 1999
Chondrocytes express CD44 as a primary receptor for the matrix macromolecule hyaluronan. Hyaluronan is responsible for the retention and organization of proteoglycan within cartilage, and hyaluronan-chondrocyte interactions are important for the assembly and maintenance of the cartilage matrix.
D J, Aguiar, W, Knudson, C B, Knudson
openaire   +2 more sources

Hyaluronan Synthases, Hyaluronan and Its CD44 Receptors in the Posterior Segment of Rabbit Eye

Ophthalmologica, 2005
To understand the possible roles of the hyaluronan synthetase (HAS)/hyaluronan (HA)/CD44 signaling system in the posterior eye segment, we investigated the expression of rabbit HAS isoforms and CD44 mRNA by RT-PCR and the level of HA by using HA assay and immunohistochemistry. HA was detectable in vitreous, retina and choroid.
Masatoshi, Murata, Saburo, Horiuchi
openaire   +2 more sources

Hyaluronan-binding proteins and receptors

Advanced Drug Delivery Reviews, 1991
Abstract Hyaluranon is a glycosaminoglycan implicated in development, repair and disease processes. It appears to regulate these processes, in part, by interacting with specific binding proteins. These proteins can be conveniently divided into those that are primarily extracellular, including aggrecan, link protein(s), versican, hyaluronection or ...
openaire   +1 more source

Hyaluronan synthases, hyaluronan, and its CD44 receptor in tissue around loosened total hip prostheses

The Journal of Pathology, 2001
Aseptic loosening of prosthetic components, the most common long-term complication after total hip replacement (THR), is characterized by the formation of a synovial membrane-like interface tissue (SMLIT). It was hypothesized that the hyaluronan synthase (HAS)/hyaluronan (HA)/HA receptor CD44 signalling system is responsible for the synovial-like ...
Y T, Konttinen, T F, Li, J, Mandelin, M, Ainola, J, Lassus, I, Virtanen, S, Santavirta, M, Tammi, R, Tammi   +8 more
openaire   +2 more sources

The regulation of sperm motility by a novel hyaluronan receptor

Fertility and Sterility, 1994
To determine if a novel receptor for hyaluronan, termed RHAMM, is responsible for the previously observed increase in sperm locomotion in response to hyaluronan and to assess whether expression of the RHAMM protein is involved in sperm motility.The RHAMM protein was localized on human sperm by immunofluorescence of fixed cells, fluorescence-activated ...
B S, Kornovski, J, McCoshen, J, Kredentser, E, Turley   +3 more
openaire   +2 more sources

Internalization of hyaluronan by chondrocytes occurs via receptor-mediated endocytosis

Journal of Cell Science, 1993
ABSTRACT Several studies have suggested that chondrocytes must have the capacity to internalize and degrade extracellular hyaluronan. In the present study we show direct evidence that hyaluronan is, in fact, endocytosed by chondrocytes and that the endocytosis is mediated via cell surface CD44/hyaluronan receptors.
Q, Hua, C B, Knudson, W, Knudson
openaire   +2 more sources

Histochemical studies of hyaluronan and the hyaluronan receptor ICAM-1 in psoriasis.

International journal of tissue reactions, 1997
Histochemical stainings of frozen sections of human normal and psoriatic skin were used to study the localization of hyaluronan (HA) and intercellular adhesion molecule 1 (ICAM-1). HA staining was found in all areas of the skin, with the exception of the stratum corneum, in both normal and psoriatic cases without any apparent quantitative differences ...
S, Gustafson, T, Wikström, L, Juhlin
openaire   +1 more source

Structure, substrate recognition and initiation of hyaluronan synthase

Nature, 2022
Jeremi Kuklewicz, Robin A Corey, Ruoya Ho   +2 more
exaly