Results 21 to 30 of about 27,059 (274)

Anticancer Therapeutics: Targeting Macromolecules and Nanocarriers to Hyaluronan or CD44, a Hyaluronan Receptor [PDF]

Molecular Pharmaceutics, 2008
The complex system involved in the synthesis, degradation and binding of the high molecular weight glycosaminoglycan hyaluronic acid (hyaluronan or HA) provides a variety of structures that can be exploited for targeted cancer therapy. In many cancers of epithelial origin there is an upregulation of CD44, a receptor that binds HA.
Virginia M, Platt, Francis C, Szoka
openaire   +2 more sources

Chain Gangs: New Aspects of Hyaluronan Metabolism

Biochemistry Research International, 2012
Hyaluronan is a matrix polymer prominent in tissues undergoing rapid growth, development, and repair, in embryology and during malignant progression. It reaches 107 Daltons in size but also exists in fragmented forms with size-specific actions.
Michael Erickson, Robert Stern
doaj   +1 more source

ALK1 controls hepatic vessel formation, angiodiversity, and angiocrine functions in hereditary hemorrhagic telangiectasia of the liver

Hepatology, EarlyView., 2022
Hepatic endothelial Alk1 signaling protects from development of vascular malformations while maintaining organ‐specific endothelial differentiation and angiocrine portmanteau of the names Wingless and Int‐1 signaling. Abstract Background and Aims In hereditary hemorrhagic telangiectasia (HHT), severe liver vascular malformations are associated with ...
Christian David Schmid, Victor Olsavszky, Manuel Reinhart, Vanessa Weyer, Felix A. Trogisch, Carsten Sticht, Manuel Winkler, Sina W. Kürschner, Johannes Hoffmann, Roxana Ola, Theresa Staniczek, Joerg Heineke, Beate K. Straub, Jens Mittler, Kai Schledzewski, Peter ten Dijke, Karsten Richter, Steven Dooley, Cyrill Géraud, Sergij Goerdt, Philipp‐Sebastian Koch   +20 more
wiley   +1 more source

The molecular regulation of oligodendrocyte development and CNS myelination by ECM proteins

Frontiers in Cell and Developmental Biology, 2022
Oligodendrocytes are myelin-forming cells in the central nervous system (CNS). The development of oligodendrocytes is regulated by a large number of molecules, including extracellular matrix (ECM) proteins that are relatively less characterized. Here, we
Momona Yamada, Miho Iwase, Binri Sasaki, Nobuharu Suzuki   +3 more
doaj   +1 more source

Hyaluronan Receptor-Mediated Tumor Cell Motlity.

Trends in Glycoscience and Glycotechnology, 1994
ヒアルロナン (以下HA) は、形態形成、傷の治癒、及び腫瘍発生のような疾病のある段階において、細胞の移動に関与する、進化的に保存された、負に荷電した大きなグリコサミノグリカンである。最近、我々はHAが、ras 遺伝子により形質転換した細胞で高レベルに産生されることと、これらの細胞の移動性に必要であることを証明した。また、これらの細胞の移動を誘起するTGF-β1は、その効果を現すためにHAを必要とする。我々は、繊維芽細胞から最近クローン化された新規の糖タンパク質であるRHAMMが、ras 形質転換型の繊維芽細胞の移動に関与していることを明らかにした。つまり、競合する抗体は、ras形質転換性の移動を阻害し、逆にゲノムRHAMMクローンが感染して細胞表層にRHAMMを過剰に産生する細胞は ...
Bing Yang, Eva A. Turley
openalex   +3 more sources

The Content and Size of Hyaluronan in Biological Fluids and Tissues

Frontiers in Immunology, 2015
Hyaluronan is a simple repeating disaccharide polymer, synthesized at the cell surface by integral membrane synthases. The repeating sequence is perfectly homogeneous, and is the same in all vertebrate tissues and fluids.
Mary K. Cowman, Hong-Gee eLee, Kathryn L. Schwertfeger, James B. McCarthy, Eva A. Turley   +4 more
doaj   +1 more source

Hyaluronan Regulates Transforming Growth Factor-β1 Receptor Compartmentalization [PDF]

Journal of Biological Chemistry, 2004
Transforming growth factor-beta1 (TGF-beta1) is a key cytokine involved in the pathogenesis of fibrosis in many organs. We previously demonstrated in renal proximal tubular cells that the engagement of the extracellular polysaccharide hyaluronan with its receptor CD44 attenuated TGF-beta1 signaling.
Takafumi, Ito, John D, Williams, Donald J, Fraser, Aled O, Phillips   +3 more
openaire   +2 more sources

Hyaluronan receptors involved in cytokine induction in monocytes [PDF]

Glycobiology, 2008
During inflammation, lower molecular weight fragments of hyaluronan accumulate, and this is known to be inflammatory and immune-stimulatory. In diseases such as inflammatory bowel disease, inflammatory cells bind to hyaluronan; however, the cellular response and molecular mechanism of hyaluronan-hyaluronan receptor interactions in mononuclear cells are
Hitoshi, Yamawaki, Satoshi, Hirohata, Toru, Miyoshi, Katsuyuki, Takahashi, Hiroko, Ogawa, Ryoko, Shinohata, Kadir, Demircan, Shozo, Kusachi, Kazuhide, Yamamoto, Yoshifumi, Ninomiya   +9 more
openaire   +2 more sources

SPERM SELECTION WITH HYALURONAN AND BLASTOCYST DEVELOPMENT AFTER ICSI

Zdravniški Vestnik, 2018
Background. Selection of mature sperm for intracytoplasmic sperm injection (ICSI) has recently been made possible by hyaluronan, a naturally occurring substance found in the cumulus cells.
Lili Bačer Kermavner, Irma Virant Klun, Eda Vrtačnik Bokal, Tomaž Tomaževič, Helena Meden Vrtovec   +4 more
doaj   +1 more source

The Hyaluronan Receptor RHAMM Regulates Extracellular-regulated Kinase [PDF]

Journal of Biological Chemistry, 1998
We have identified two RHAMM (receptor for hyaluronan-mediated motility) isoforms that encode an alternatively spliced exon 4 (Hall, C. L., Yang, B., Yang, X., Zhang, S., Turley, M., Samuel, S., Lange, L. A., Wang, C., Curpen, G. D., Savani, R. C., Greenberg, A. H., and Turley, E. A.
Zhang, S., Chang, M. C., Zylka, D., Turley, S., Harrison, R., Turley, E. A.   +5 more
openaire   +2 more sources