Results 31 to 40 of about 2,309,824 (325)

Identification of two hyaluronan-binding domains in the hyaluronan receptor RHAMM. [PDF]

Journal of Biological Chemistry, 1993
We have identified two discrete hyaluronan- (HA) binding domains in the HA receptor RHAMM (Receptor for HA-Mediated Motility) that mediates the locomotion of H-ras transformed fibroblasts. A complete RHAMM cDNA (1.43 kilobases (kb)) was expressed as a fusion protein with pGEX-2T in Escherichia coli HB101 and was shown to bind specifically to both ...
Eva A. Turley, Baihua Yang, Liying Zhang
openaire   +2 more sources

Hyaluronan in the Cancer Cells Microenvironment

Cancers, 2023
Simple Summary The extracellular matrix has a complex structure, and the glycans within are difficult to study, but are able to elicit multiple effects on resident and immune cells, with a crucial role being exerted by hyaluronan.
E. Karousou, Arianna Parnigoni, P. Moretto, A. Passi, M. Viola, D. Vigetti   +5 more
semanticscholar   +1 more source

Anticancer Therapeutics: Targeting Macromolecules and Nanocarriers to Hyaluronan or CD44, a Hyaluronan Receptor [PDF]

Molecular Pharmaceutics, 2008
The complex system involved in the synthesis, degradation and binding of the high molecular weight glycosaminoglycan hyaluronic acid (hyaluronan or HA) provides a variety of structures that can be exploited for targeted cancer therapy. In many cancers of epithelial origin there is an upregulation of CD44, a receptor that binds HA.
Francis C. Szoka, Virginia M. Platt
openaire   +3 more sources

Ovarian Cancer-Cell Pericellular Hyaluronan Deposition Negatively Impacts Prognosis of Ovarian Cancer Patients

Biomedicines, 2022
Background: Hyaluronan (HA), a component of the extracellular matrix, is frequently increased under pathological conditions including cancer. Not only stroma cells but also cancer cells themselves synthesize HA, and the interaction of HA with its cognate
Leticia Oliveira-Ferrer, Barbara Schmalfeldt, Johannes Dietl, Catharina Bartmann, Udo Schumacher, Christine Stürken   +5 more
doaj   +1 more source

Hyaluronan: Biosynthesis and signaling [PDF]

, 2014
Background Hyaluronan is a critical component of extracellular matrix with several different roles. Besides the contribution to the tissue hydration, mechanical properties and correct architecture, hyaluronan plays important biological functions ...
De Luca, G., Deleonibus, S., Karousou, E., Passi, A., Vigetti, D., Viola, M.   +5 more
core   +1 more source

Lipid raft-mediated regulation of hyaluronan-CD44 interactions in inflammation and cancer

Frontiers in Immunology, 2015
Hyaluronan is a major component of the extracellular matrix and plays pivotal roles in inflammation and cancer. Hyaluronan oligomers are frequently found in these pathological conditions, in which they exert their effects via association with the ...
Toshiyuki eMurai
doaj   +1 more source

TLR5 participates in the TLR4 receptor complex and promotes MyD88-dependent signaling in environmental lung injury

eLife, 2020
Lung disease causes significant morbidity and mortality, and is exacerbated by environmental injury, for example through lipopolysaccharide (LPS) or ozone (O3). Toll-like receptors (TLRs) orchestrate immune responses to injury by recognizing pathogen- or
Salik Hussain, Collin G Johnson, Joseph Sciurba, Xianglin Meng, Vandy P Stober, Caini Liu, Jaime M Cyphert-Daly, Katarzyna Bulek, Wen Qian, Alma Solis, Yosuke Sakamachi, Carol S Trempus, Jim J Aloor, Kym M Gowdy, W Michael Foster, John W Hollingsworth, Robert M Tighe, Xiaoxia Li, Michael B Fessler, Stavros Garantziotis   +19 more
doaj   +1 more source

Hyaluronan and the Fascial Frontier

International Journal of Molecular Sciences, 2021
The buzz about hyaluronan (HA) is real. Whether found in face cream to increase water volume loss and viscoelasticity or injected into the knee to restore the properties of synovial fluid, the impact of HA can be recognized in many disciplines from ...
Rebecca L Pratt
semanticscholar   +1 more source

Hyaluronan and Hyaluronidase, which is better for embryo development? [PDF]

, 2016
Our aim was to examine size-specific effects of Hyaluronan (HA) on preimplantation embryo development. We investigated the effects of Hyalovet (HA, 500–750 kDa; the size produced by HA synthase-3, which is abundant in the oviduct), or HA treated with ...
Ali A. Fouladi-Nashta, Aruffo, Aviles, Bastow, Bergqvist, Block, Bourguignon, Choudhary, Csoka, Dicker, Fenwick, Fouladi-Nashta, Furnus, Furnus, Georgiou, Hahnel, Hess, Kabir A. Raheem, Lane, Laurent, Lesley, Lloyd, Marei, Marei, Mariani, Matwee, Mazdak Salavati, Mehta, Mohey-Elsaeed, Muhammad Khalid, Neira, Oesterreicher, Ohno-Nakahara, Pandey, Pushpakumara, Raheem, Robinson, Rozen, Russell, Ryan, Saliba, Schmidt, Seytanoglu, Stern, Stevenson, Tienthai, Tina Tremaine, Tombolan, Toole, Torner, Ulbrich, Waleed F.A. Marei, Wang, Wathes, Watson, Way, Weigel, Xu, Yevdokimova, Yoon   +59 more
core   +1 more source

Influence of hyaluronan on endometrial receptivity and embryo attachment in sheep [PDF]

, 2017
An increasing number of reports suggests a role of hyaluronan (HA) in female reproduction and interest in its application in assisted reproduction is rising.
Fouladi-Nashta, A A, Ghafari, F, Marei, W F A, Mohey-Elsaeed, O, Raheem, K A, Wathes, D C   +5 more
core   +1 more source