Results 31 to 40 of about 27,059 (274)
Dissecting the Dual Nature of Hyaluronan in the Tumor Microenvironment
Frontiers in Immunology, 2019 Hyaluronan (HA) is a glycosaminoglycan with a simple structure but diverse and often opposing functions. The biological activities of this polysaccharide depend on its molecular weight and the identity of interacting receptors.
Muhan Liu +3 more
doaj +1 more source
Cell Death Discovery, 2021 The extracellular matrix plays a key role in cancer progression. Hyaluronan, the main glycosaminoglycan of the extracellular matrix, has been related to several tumor processes. Hyaluronan acts through the interaction with cell membrane receptors as CD44
Matías Arturo Pibuel +6 more
doaj +1 more source
Hyaluronan Regulates Cell Behavior: A Potential Niche Matrix for Stem Cells
Biochemistry Research International, 2012 Hyaluronan is a linear glycosaminoglycan that has received special attention in the last few decades due to its extraordinary physiological functions.
Mairim Alexandra Solis +5 more
doaj +1 more source
Hyaluronan goes to great length
Cell Stress, 2020 Hyaluronan is a major non-protein component of extracellular matrix that affects biomechanical properties of tissues and interacts with cell receptors.
Vera Gorbunova +2 more
doaj +1 more source
mBio, 2023 Bacterial infections remain a significant cause of adverse pregnancy outcomes. Ascending infection of group B streptococcus (GBS) or Streptococcus agalactiae from the lower genital tract to the amniotic cavity leads to fetal injury, preterm births, or ...
Michelle Coleman +13 more
doaj +1 more source
The hyaluronan receptor (CD44) participates in the uptake and degradation of hyaluronan. [PDF]
The Journal of cell biology, 1992 The hyaluronan receptor belongs to the polymorphic family of CD44 glycoproteins, which have been implicated in a variety of cellular functions including adhesion to hyaluronan and collagen, the binding of lymphocytes to high endothelial cells during extravasation, and conferring metastatic potential to carcinoma cells.
M, Culty, H A, Nguyen, C B, Underhill
openaire +2 more sources
Versican—A Critical Extracellular Matrix Regulator of Immunity and Inflammation
Frontiers in Immunology, 2020 The extracellular matrix (ECM) proteoglycan, versican increases along with other ECM versican binding molecules such as hyaluronan, tumor necrosis factor stimulated gene-6 (TSG-6), and inter alpha trypsin inhibitor (IαI) during inflammation in a number ...
Thomas N. Wight +7 more
doaj +1 more source
What is special about 200 kDa hyaluronan that activates hyaluronan receptor signaling? [PDF]
Glycobiology, 2017 The polydispersity of hyaluronan (HA) presents challenges for analyzing its solution properties, such as the relationship between mass and particle size. The broad mass range of natural HA (≤50-fold) makes molecular characterization difficult and ambiguous compared to molecules with known molecular weights (e.g., proteins).
Paul H, Weigel, Bruce A, Baggenstoss
openaire +2 more sources
Ligand Binding and Signaling of HARE/Stabilin-2
Biomolecules, 2019 The Stabilin receptors are a two-member family in the type H class of scavenger receptors. These dynamic receptors bind and internalize multiple ligands from the cell surface for the purpose of clearing extracellular material including some synthetic ...
Edward N. Harris, Fatima Cabral
doaj +1 more source
Biomolecules, 2019 Since the discovery of a novel liver hyaluronan (HA) clearance receptor in 1981 by Laurent, Fraser and coworkers, 22 different ligands cleared by the renamed receptor (the Hyaluronan Receptor for Endocytosis (HARE); Stabilin-2 (Stab2)) were discovered ...
Paul H. Weigel
doaj +1 more source