What is special about 200 kDa hyaluronan that activates hyaluronan receptor signaling? [PDF]
Glycobiology, 2017 The polydispersity of hyaluronan (HA) presents challenges for analyzing its solution properties, such as the relationship between mass and particle size. The broad mass range of natural HA (≤50-fold) makes molecular characterization difficult and ambiguous compared to molecules with known molecular weights (e.g., proteins).
Paul H. Weigel, Bruce A. Baggenstoss
openaire +3 more sources
Hyaluronan Regulates Cell Behavior: A Potential Niche Matrix for Stem Cells
Biochemistry Research International, 2012 Hyaluronan is a linear glycosaminoglycan that has received special attention in the last few decades due to its extraordinary physiological functions.
Mairim Alexandra Solis +5 more
doaj +1 more source
Versican—A Critical Extracellular Matrix Regulator of Immunity and Inflammation
Frontiers in Immunology, 2020 The extracellular matrix (ECM) proteoglycan, versican increases along with other ECM versican binding molecules such as hyaluronan, tumor necrosis factor stimulated gene-6 (TSG-6), and inter alpha trypsin inhibitor (IαI) during inflammation in a number ...
Thomas N. Wight +7 more
doaj +1 more source
A Blocking Antibody to the Hyaluronan Receptor for Endocytosis (HARE) Inhibits Hyaluronan Clearance by Perfused Liver [PDF]
Journal of Biological Chemistry, 2003 Hyaluronan (HA) and chondroitin sulfate clearance from lymph and blood is mediated by the hyaluronan receptor for endocytosis (HARE). The purification and molecular cloning (Zhou, B., Weigel, J. A., Saxena, A., and Weigel, P. H. (2002) Mol. Biol. Cell 13, 2853-2868) of this cell surface receptor were finally achieved after we developed monoclonal ...
Paul H. Weigel +4 more
openaire +3 more sources
Increased levels of hyaluronic acid in bronchoalveolar lavage from patients with interstitial lung diseases, relationship with lung function and inflammatory cells recruitment [PDF]
, 2014 Purpose: Interstitial Lung Diseases (ILD) are characterized by inflammation and fibrosis. It described the role of hyaluronic acid (HA) as an immune-regulator. It is not known if HA contributes to the recruitment of inflammatory cells associated with ILD.
Auteri, Santiago +6 more
core +1 more source
Hyaluronan-Conjugated Carbon Quantum Dots for Bioimaging Use
ACS Applied Materials and Interfaces, 2020 This work demonstrates the application of hyaluronan-conjugated nitrogen-doped carbon quantum dots (HA-nCQDs) for bioimaging of tumor cells and illustrates their potential use as carriers in targeted drug delivery. Quantum dots are challenging to deliver
B. Karakocak +5 more
semanticscholar +1 more source
Localization of hyaluronan and the hyaluronan receptor ICAM-1 in rheumatoid synovia—a histochemical study [PDF]
Acta Orthopaedica Scandinavica, 1995 The major site for elimination of HA from the bloodstream is via receptor mediated endocytosis by liver endothelial cells (LEC) (Fraser and Laurent 1989, Laurent and Fraser 1992). The HA receptor (HAR) on LEC has been characterized and isolated from rat LEC membranes (Forsberg and Gustafson 1991).
Stefan Gustafson +3 more
openaire +2 more sources
Hyaluronan-CD44 interaction promotes microRNA signaling and RhoGTPase activation leading to tumor progression. [PDF]
, 2012 A hallmark of all solid tumor malignancies is the ability to invade the surrounding tissue and/or metastasize to distant sites. Tumors cells have altered signaling pathways which that to cytoskeleton activation and migration.
Bourguignon, Lilly YW
core +1 more source
Ligand Binding and Signaling of HARE/Stabilin-2
Biomolecules, 2019 The Stabilin receptors are a two-member family in the type H class of scavenger receptors. These dynamic receptors bind and internalize multiple ligands from the cell surface for the purpose of clearing extracellular material including some synthetic ...
Edward N. Harris, Fatima Cabral
doaj +1 more source
The Hyaluronan Receptor RHAMM Regulates Extracellular-regulated Kinase [PDF]
Journal of Biological Chemistry, 1998 We have identified two RHAMM (receptor for hyaluronan-mediated motility) isoforms that encode an alternatively spliced exon 4 (Hall, C. L., Yang, B., Yang, X., Zhang, S., Turley, M., Samuel, S., Lange, L. A., Wang, C., Curpen, G. D., Savani, R. C., Greenberg, A. H., and Turley, E. A.
Zhang, S. +5 more
openaire +3 more sources