Results 101 to 110 of about 20,143 (217)

Hyaluronan Synthase of Chlorella Virus PBCV-1

Science, 1997
Sequence analysis of the 330-kilobase genome of the virus PBCV-1 that infects a chlorella-like green algae revealed an open reading frame, A98R, with similarity to several hyaluronan synthases. Hyaluronan is an essential polysaccharide found in higher animals as well as in a few pathogenic bacteria. Expression of the A98R
DeAngelis, Paul L., Jing, Wei, Graves, Michael V., Burbank, Dwight E., Van Etten, James L.   +4 more
openaire   +3 more sources

Nanoscopic Mapping of the Extracellular Space in Amyloid Plaque‐rich Cortex

Advanced Science, Volume 13, Issue 1, 5 January 2026.
The extracellular space and diffusion around amyloid plaques are examined using shadow imaging and single‐particle tracking. Increased diffusivity is found near plaques, extracellular matrix alterations, and plaque core penetrability that varies with amyloid phenotype.
Juan Estaún‐Panzano, Yulia Dembitskaya, Ivo Calaresu, Somen Nandi, Quentin Gresil, Evelyne Doudnikoff, Thierry Leste‐Lasserre, Thierry Amédée, Laurent Cognet, Laurent Groc, Urs Valentin Nägerl, Erwan Bezard   +11 more
wiley   +1 more source

Inhibition of Oesophageal Squamous Cell Carcinoma Progression by in vivo Targeting of Hyaluronan Synthesis

Molecular Cancer, 2011
Background Oesophageal cancer is a highly aggressive tumour entity with at present poor prognosis. Therefore, novel treatment options are urgently needed.
Savani Rashmin C, Stoecklein Nikolas H, Knoefel Wolfram T, Prenzel Klaus, Alves Frauke, Dullin Christian, Jannasch Katharina, Dai Guang, Poscher Eva, Freudenberger Till, Twarock Sören, Homey Bernhard, Fischer Jens W   +12 more
doaj   +1 more source

A Sweet Talk: The Molecular Systems of Perineuronal Nets in Controlling Neuronal Communication [PDF]

, 2017
Perineuronal nets (PNNs) are mesh-like structures, composed of a hierarchical assembly of extracellular matrix molecules in the central nervous system (CNS), ensheathing neurons and regulating plasticity.
Arranz, Baig, Banerjee, Baranova, Barritt, Beebe, Beurdeley, Blosa, Bradbury, Brakebusch, Brückner, Brückner, Bukalo, Bukalo, Cabungcal, Caillard, Carstens, Carulli, Carulli, Carulli, Chang, Cheah, Corvetti, Coulson-Thomas, Dauth, Day, de Winter, Deepa, Deepa, Dick, Dityatev, Donato, Favuzzi, Foscarin, Frischknecht, Galtrey, Galtrey, Geissler, Giamanco, Gogolla, Grøndahl, Gu, Gurevicius, Happel, Heleen M. van 't Spijker, Hensch, Hisaoka, Hylin, Härtig, Härtig, Jansen, Jessica C. F. Kwok, Kochlamazashvili, Kwok, Kwok, Lafarga, Lander, Lee, Lensjø, Lensjø, Mabuchi, Matthews, McRae, Miyata, Miyata, Miyata, Morawski, Morawski, Morawski, Morikawa, Orlando, Pantazopoulos, Pelkey, Pizzorusso, Pizzorusso, Romberg, Rossier, Shinozaki, Smith, Spatazza, Spreafico, Steullet, Sugiyama, Suttkus, Suzuki, Vo, Wang, Yamada, Ye   +88 more
core   +2 more sources

The Role of Macrophages in Cancer: From Basic Research to Clinical Applications

MedComm, Volume 7, Issue 1, January 2026.
Monocytes infiltrate the tumor microenvironment (TME) and differentiate into macrophages, which polarize into proinflammatory, antitumor M1 cells or immunosuppressive, protumor M2 cells. Within the TME, M2‐type tumor‐associated macrophages (TAMs) predominate and drive tumor growth, angiogenesis, and metastasis. Therapeutic strategies therefore focus on
Zhimei Liu, Yan Li, Jingchao Cao, Yefeng Qiu, Kun Yu, Shoulong Deng   +5 more
wiley   +1 more source

Hypoxia promotes redifferentiation and suppresses markers of hypertrophy and degeneration in both healthy and osteoarthritic chondrocytes [PDF]

, 2013
INTRODUCTION: Hypoxia is considered to be a positive influence on the healthy chondrocyte phenotype and cartilage matrix formation. However, hypoxia-inducible factors (HIFs) have been implicated in the pathogenesis of osteoarthritis (OA).
Brandon D Markway, Brian Johnstone, Holly Cho   +2 more
core   +1 more source

Current Status of Research on Losartan in Tumour Therapy

Journal of Cellular and Molecular Medicine, Volume 30, Issue 1, January 2026.
ABSTRACT Losartan, a widely prescribed antihypertensive agent, has attracted growing interest as a potential adjuvant in cancer therapy due to its affordability, established safety profile and pleiotropic effects. Emerging preclinical evidence demonstrates that losartan can effectively modulate the tumour microenvironment (TME) by inhibiting ...
Han Wang, Shuang Yuan, Hongjing Wang
wiley   +1 more source

Effect of modulating the extracellular matrix cross linkage by genipin on tumor cell resistance and survival in thioacetamide-induced hepatocellular carcinoma in rats [PDF]

PeerJ
Background Previous studies on patients and rats with hepatocellular carcinoma (HCC) have shown significant changes in the extracellular matrix (ECM). Versican, a component of the ECM, forms extensive multimolecular interactions with other ECM components,
Hanan M. Hassan, Mohammed Baradwan, Alaa Bagalagel, Reem Diri, Ahmed Basilim, Mohammed Z. Nasrullah, Abdulhamid Althagafi, Hussam I. Kutbi, Abdulaziz A. Mohammed, Hanan M. Alshan, Mohammed M.H. Al-Gayyar   +10 more
doaj   +2 more sources

Management of Osteoarthritis with Avocado/Soybean Unsaponifiables. [PDF]

, 2015
Osteoarthritis (OA) is a painful and life-altering disease that severely limits the daily activity of millions of Americans, and is one of the most common causes of disability in the world. With obesity on the rise and the worlds population living longer,
Bhatti, Simi, Christiansen, Blaine, Emami, Shahin, Goudarzi, Ramin   +3 more
core   +1 more source

Hyaluronan Synthases [PDF]

Journal of Biological Chemistry, 1997
P H, Weigel, V C, Hascall, M, Tammi
openaire   +2 more sources