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Decreased expression of hyaluronan synthase 1 and 2 associates with poor prognosis in cutaneous melanoma. [PDF]
BMC Cancer, 2016 Poukka M +6 more
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Unvaporized e-liquid toxicity elevates CD44-dependent hyaluronan catabolic gene expression and triggers inflammation in human vocal fold fibroblasts. [PDF]
Toxicol RepBasu K, Li J, Mongeau L.
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Hyaluronan and Hyaluronan Synthases: Potential Therapeutic Targets in Cancer
Current Drug Target -Cardiovascular & Hematological Disorders, 2005Current models of oncogenesis describe cancer as a progression of genetic mutations in a tumor cell mass. However, tumors are more than a clonal expansion of malignant cells. Tumors are heterogeneous, with a complex 3D structure, analogous to organs comprised of different tissues.
Sophia, Adamia +2 more
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Role of hyaluronan and hyaluronan synthase in endometrial cancer
Oncology Reports, 2005The aim of this study was to determine if the immunohistochemical expression of hyaluronan synthase (HAS) and serum levels of hyaluronan correlate with the clinicopathological manifestations of endometrial carcinoma. Sera were obtained from 59 endometrial cancer patients and 22 post-menopausal healthy women.
Hiromitsu, Yabushita +7 more
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Analysis of Hyaluronan Synthase Activity
2014Hyaluronan (HA) is a component of the extracellular matrix that is involved in many physiological and pathological processes. As HA modulates several functions (i.e., cell proliferation and migration, inflammation), its presence in the tissues can have positive or negative effects.
Davide, Vigetti +3 more
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Hyaluronan synthase expression in ovarian cancer
Oncology Reports, 2004To determine if the immunohistochemical expression of hyaluronan synthase (HAS) correlates with the clinicopathological manifestations or clinical outcomes of ovarian carcinoma, sections of tumor tissue from 33 ovarian cancer patients were immunostained by the avidin-biotin-peroxidase complex method using anti-HAS1, anti-HAS2, anti-HAS3 and anti-CD44 ...
Hiromitsu, Yabushita +7 more
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Hyaluronan Synthases Posttranslational Regulation in Cancer
2014Hyaluronan (HA) is a critical component of cancer microenvironment that is known to increase tumor progression and aggressiveness. The synthesis of HA starts from the cytosolic precursors UDP-N-acetylglucosamine and UDP-glucuronic acid. These two sugar nucleotides have several functions in addition to glycoconjugate synthesis and glucuronidation ...
VIGETTI, DAVIDE, PASSI, ALBERTO
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Molecular Cloning of Human Hyaluronan Synthase
Biochemical and Biophysical Research Communications, 1996We report here the cDNA sequence of human hyaluronan synthase. The cDNA clone was isolated from a human fetal brain cDNA library by screening with a DNA probe generated from the coding sequence of murine hyaluronan synthase. It contains a 2107 bp cDNA insert which is composed of a 1629 bp open reading frame and a short segment of the 3'-untranslated ...
N, Itano, K, Kimata
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Phosphorylation of Thr328 in hyaluronan synthase 2 is essential for hyaluronan synthesis
Biochemical and Biophysical Research Communications, 2020Hyaluronan synthase 2 (HAS2) is an integral membrane protein composed of multi-membrane-spanning regions and a large intracellular loop (HAS2-loop). We previously examined the effect of phorbol 12-myristate 13-acetate (PMA) and/or 4-methylumbelliferone (4-MU) on the synthesis of hyaluronan (HA) in human skin fibroblasts and found that TPA and 4-MU have
Kosuke Kasai +7 more
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