Results 1 to 10 of about 10,002 (164)

4-Methylumebelliferone Enhances Radiosensitizing Effects of Radioresistant Oral Squamous Cell Carcinoma Cells via Hyaluronan Synthase 3 Suppression [PDF]

Cells, 2022
Radioresistant (RR) cells are poor prognostic factors for tumor recurrence and metastasis after radiotherapy. The hyaluronan (HA) synthesis inhibitor, 4-methylumbelliferone (4-MU), shows anti-tumor and anti-metastatic effects through suppressing HA ...
Kazuki Hasegawa, Ryo Saga, Yoshikazu Kuwahara   +2 more
exaly   +4 more sources

Melatonin promotes neuroblastoma cell differentiation by activating hyaluronan synthase 3-induced mitophagy. [PDF]

Cancer Med, 2019
Neuroblastoma is the second most common pediatric malignancy and has a high rate of spontaneous remission. Uncovering the mechanisms underlying neuroblastoma cell differentiation is critical for therapeutic purposes.
Lee WJ, Chen LC, Lin JH, Cheng TC, Kuo CC, Wu CH, Chang HW, Tu SH, Ho YS.   +8 more
europepmc   +5 more sources

Hyaluronan synthase 3 deficiency lowers the incidence of ruptures of abdominal aortic aneurysms by reducing monocyte infiltration. [PDF]

Front Immunol
IntroductionAbdominal aortic aneurysms and dissections (AAA/AD) are vascular disorders with high mortality due to aortic ruptures. Critical pathomechanisms involve immune cell infiltration and degradation of the vascular extracellular matrix (ECM ...
Niemann V, Brack F, Rolauer L, Kaczur J, Petzsch P, Köhrer K, Quast C, Gerdes N, Bouvain P, Voigt K, Krüger M, Brückner A, Fleischmann BK, Wenzel D, Barnowski P, Zimmermann LM, Simsekyilmaz S, Filler T, Ibing W, Feige T, Krott KJ, Wagenhäuser MU, Fischer JW, Elvers M, Sengle G, Flögel U, Hundhausen C, Suvorava T, Grandoch M.   +28 more
europepmc   +4 more sources

A Connecting Link between Hyaluronan Synthase 3-Mediated Hyaluronan Production and Epidermal Function [PDF]

International Journal of Molecular Sciences, 2022
Hyaluronan (HA), an essential component of the extracellular matrix of the skin, is synthesized by HA synthases (HAS1-3). To date, epidermal HA has been considered a major player in regulating cell proliferation and differentiation. However, a previous study reported that depletion of epidermal HA by Streptomyces hyaluronidase (St-HAase) has no ...
Hiroyuki Yoshida, Yoko Endo, Tetsuya Sayo   +2 more
exaly   +5 more sources

Hydrocellular foam dressing promotes wound healing along with increases in hyaluronan synthase 3 and PPARα gene expression in epidermis. [PDF]

PLoS One, 2013
BackgroundHydrocellular foam dressing, modern wound dressing, induces moist wound environment and promotes wound healing: however, the regulatory mechanisms responsible for these effects are poorly understood. This study was aimed to reveal the effect of
Yamane T, Nakagami G, Yoshino S, Muramatsu A, Matsui S, Oishi Y, Kanazawa T, Minematsu T, Sanada H.   +8 more
europepmc   +2 more sources

Type-3 Hyaluronan Synthase Attenuates Tumor Cells Invasion in Human Mammary Parenchymal Tissues [PDF]

Molecules, 2021
The microenvironment for tumor growth and developing metastasis should be essential. This study demonstrated that the hyaluronic acid synthase 3 (HAS3) protein and its enzymatic product hyaluronic acid (HA) encompassed in the subcutaneous extracellular ...
Wen-Jui Lee, Shih-Hsin Tu, Tzu-Chun Cheng, Juo-Han Lin, Ming-Thau Sheu, Ching-Chuan Kuo, Chun A. Changou, Chih-Hsiung Wu, Hui-Wen Chang, Hang-Lung Chang, Li-Ching Chen, Yuan-Soon Ho   +11 more
doaj   +3 more sources

Hyaluronan Synthase 3 Null Mice Exhibit Decreased Intestinal Inflammation and Tissue Damage in the DSS-Induced Colitis Model. [PDF]

Int J Cell Biol, 2015
Hyaluronan (HA) overproduction is a hallmark of multiple inflammatory diseases, including inflammatory bowel disease (IBD). Hyaluronan can act as a leukocyte recruitment molecule and in the most common mouse model of intestinal inflammation, the ...
Kessler SP, Obery DR, de la Motte C.
europepmc   +2 more sources

Hyaluronan nanoscale clustering and Hyaluronan synthase 2 expression are linked to the invasion of child fibroblasts and infantile fibrosarcoma in vitro and in vivo

Scientific Reports, 2022
Infantile fibrosarcoma is a rare childhood tumour that originates in the fibrous connective tissue of the long bones for which there is an urgent need to identify novel therapeutic targets.
Joseph J. Tonge, Scott V. Notley, Mark J. Dunning, Ana López-Guajardo, Jessica D. Medcalf, Paraskevi Heldin, George Panoutsos, Annica K. B. Gad   +7 more
doaj   +1 more source

Mycobacteria exploit host hyaluronan for efficient extracellular replication. [PDF]

PLoS Pathogens, 2009
In spite of the importance of hyaluronan in host protection against infectious organisms in the alveolar spaces, its role in mycobacterial infection is unknown.
Yukio Hirayama, Mamiko Yoshimura, Yuriko Ozeki, Isamu Sugawara, Tadashi Udagawa, Satoru Mizuno, Naoki Itano, Koji Kimata, Aki Tamaru, Hisashi Ogura, Kazuo Kobayashi, Sohkichi Matsumoto   +11 more
doaj   +1 more source

The role of the multifaceted long non-coding RNAs: A nuclear-cytosolic interplay to regulate hyaluronan metabolism

Matrix Biology Plus, 2021
In the extracellular matrix (ECM), the glycosaminoglycan (GAG) hyaluronan (HA) has different physiological roles favouring hydration, elasticity and cell survival.
Arianna Parnigoni, Ilaria Caon, Paola Moretto, Manuela Viola, Evgenia Karousou, Alberto Passi, Davide Vigetti   +6 more
doaj   +1 more source