Results 41 to 50 of about 10,002 (164)

Inhibition of hyaluronan synthase-3 decreases subcutaneous colon cancer growth by increasing apoptosis. [PDF]

Anticancer Agents Med Chem, 2011
Hyaluronan (HA) and hyaluronan synthases (HAS) have been implicated in cancer growth and progression. We previously have shown that HAS3 and HA mediate tumor growth in SW620 colon cancer cells, but the mechanism remains poorly understood. In addition, the effect of HAS3 inhibition on tumor growth with other cells lines has not been explored.
Teng BP, Heffler MD, Lai EC, Zhao YL, LeVea CM, Golubovskaya VM, Bullarddunn KM.   +6 more
europepmc   +4 more sources

Novel Gene Expression Profile of Women with Intrinsic Skin Youthfulness by Whole Transcriptome Sequencing. [PDF]

PLoS ONE, 2016
While much is known about genes that promote aging, little is known about genes that protect against or prevent aging, particularly in human skin. The main objective of this study was to perform an unbiased, whole transcriptome search for genes that ...
Jin Xu, Robert C Spitale, Linna Guan, Ryan A Flynn, Eduardo A Torre, Rui Li, Inbar Raber, Kun Qu, Dale Kern, Helen E Knaggs, Howard Y Chang, Anne Lynn S Chang   +11 more
doaj   +1 more source

Anti-Müllerian Hormone Inhibits FSH-Induced Cumulus Oocyte Complex In Vitro Maturation and Cumulus Expansion in Mice

Animals, 2022
Anti-Müllerian hormone (AMH) is secreted by the ovaries of female animals and exerts its biological effects through the type II receptor (AMHR2). AMH regulates follicular growth by inhibiting the recruitment of primordial follicles and reducing the ...
Xue Yu, Zan Li, Xinzhe Zhao, Liping Hua, Shuanghang Liu, Changjiu He, Liguo Yang, John S. Davis, Aixin Liang   +8 more
doaj   +1 more source

Super Enhancer Driven Hyaluronan Synthase 3 Promotes Malignant Progression of Nasopharyngeal Carcinoma

Journal of Cancer, 2023
Nasopharyngeal carcinoma (NPC) is a malignant tumor of the head and neck with high metastatic and invasive nature. Super enhancers (SEs) control the expression of cell identity genes and oncogenes during tumorigenesis. As a glycosaminoglycan in the tumor microenvironment, hyaluronan (HA) is associated with cancer development.
Chen, Quanzhu, Peng, Qian, Cai, Jing, Liu, Ying, Lu, Xingxing, Xiong, Wei, Zeng, Zhaoyang, Li, Guiyuan, Li, Xiaoling, Li, Xiayu, Xiang, Bo, Yi, Mei, Chen, Pan   +12 more
openaire   +2 more sources

Expression of Hyaluronan Synthases (HAS1–3) and Hyaluronidases (HYAL1–2) in Serous Ovarian Carcinomas: Inverse Correlation between HYAL1 and Hyaluronan Content [PDF]

BMC Cancer, 2009
Abstract Background Hyaluronan, a tumor promoting extracellular matrix polysaccharide, is elevated in malignant epithelial ovarian tumors, and associates with an unfavorable prognosis. To explore possible contributors to the accumulation of hyaluronan, we examined the expression of hyaluronan synthases (HAS1, HAS2 and
Heikkinen Anna-Mari, Hämäläinen Kirsi, Tammi Raija H, Tammi Markku I, Sironen Reijo, Rilla Kirsi, Nykopp Timo K, Komulainen Marja, Kosma Veli-Matti, Anttila Maarit   +9 more
openaire   +3 more sources

Inhibition of Oesophageal Squamous Cell Carcinoma Progression by in vivo Targeting of Hyaluronan Synthesis

Molecular Cancer, 2011
Background Oesophageal cancer is a highly aggressive tumour entity with at present poor prognosis. Therefore, novel treatment options are urgently needed.
Savani Rashmin C, Stoecklein Nikolas H, Knoefel Wolfram T, Prenzel Klaus, Alves Frauke, Dullin Christian, Jannasch Katharina, Dai Guang, Poscher Eva, Freudenberger Till, Twarock Sören, Homey Bernhard, Fischer Jens W   +12 more
doaj   +1 more source

Matrix Remodeling and Hyaluronan Production by Myofibroblasts and Cancer-Associated Fibroblasts in 3D Collagen Matrices

Gels, 2020
The tumor microenvironment is a key modulator in cancer progression and has become a novel target in cancer therapy. An increase in hyaluronan (HA) accumulation and metabolism can be found in advancing tumor progression and are often associated with ...
Jiranuwat Sapudom, Claudia Damaris Müller, Khiet-Tam Nguyen, Steve Martin, Ulf Anderegg, Tilo Pompe   +5 more
doaj   +1 more source

Alteration of introns in a hyaluronan synthase 1 (HAS1) minigene convert Pre-mRNA [corrected] splicing to the aberrant pattern in multiple myeloma (MM): MM patients harbor similar changes. [PDF]

PLoS ONE, 2013
Aberrant pre-mRNA splice variants of hyaluronan synthase 1 (HAS1) have been identified in malignant cells from cancer patients. Bioinformatic analysis suggests that intronic sequence changes can underlie aberrant splicing.
Jitra Kriangkum, Amanda Warkentin, Andrew R Belch, Linda M Pilarski   +3 more
doaj   +1 more source

Effect of modulating the extracellular matrix cross linkage by genipin on tumor cell resistance and survival in thioacetamide-induced hepatocellular carcinoma in rats [PDF]

PeerJ
Background Previous studies on patients and rats with hepatocellular carcinoma (HCC) have shown significant changes in the extracellular matrix (ECM). Versican, a component of the ECM, forms extensive multimolecular interactions with other ECM components,
Hanan M. Hassan, Mohammed Baradwan, Alaa Bagalagel, Reem Diri, Ahmed Basilim, Mohammed Z. Nasrullah, Abdulhamid Althagafi, Hussam I. Kutbi, Abdulaziz A. Mohammed, Hanan M. Alshan, Mohammed M.H. Al-Gayyar   +10 more
doaj   +2 more sources

Hyaluronan synthase 2 expressed by cancer-associated fibroblasts promotes oral cancer invasion

Journal of Experimental & Clinical Cancer Research, 2016
Background Hyaluronan synthases (HAS) control the biosynthesis of hyaluronan (HA) and critically modulate the tumor microenviroment. Cancer-associated fibroblasts (CAFs) affect the progression of a tumor by remolding the matrix.
Ziwen Zhang, Detao Tao, Ping Zhang, Xue Liu, Yuchao Zhang, Jie Cheng, Hua Yuan, Laikui Liu, Hongbing Jiang   +8 more
doaj   +1 more source