Results 21 to 30 of about 10,002 (164)

Hyaluronan synthases (HAS1-3) and hyaluronidases (HYAL1-2) in the accumulation of hyaluronan in endometrioid endometrial carcinoma [PDF]

BMC Cancer, 2010
Abstract Background Hyaluronan accumulation correlates with the degree of malignancy in many solid tumor types, including malignant endometrial carcinomas. To elucidate the mechanism of hyaluronan accumulation, we examined the expression levels of the hyaluronan synthases (HAS1, HAS2 and HAS3) and hyaluronidases ...
Kosma Veli-Matti, Hämäläinen Kirsi, Sironen Reijo, Tammi Raija H, Rilla Kirsi, Tammi Markku I, Nykopp Timo K, Heinonen Seppo, Anttila Maarit   +8 more
openaire   +3 more sources

Platelet Hyaluronan Synthase 3 Regulates Thrombin Signaling and Adhesion to Fibrinogen Under Venous Shear. [PDF]

Proteoglycan Res
ABSTRACTHyaluronan (HA) is an essential glycosaminoglycan with supportive roles in hematopoiesis. HA is synthesized by hyaluronan synthases (HAS1, HAS2, and HAS3) and plays a crucial role in cellular signaling and extracellular matrix interactions.
Queisser KA, Smith L, Leung G, Albtoush N, Mellema RA, Petrey AC.   +5 more
europepmc   +4 more sources

Hyaluronic acid synthesis is required for zebrafish tail fin regeneration. [PDF]

PLoS ONE, 2017
Using genome-wide transcriptional profiling and whole-mount expression analyses of zebrafish larvae, we have identified hyaluronan synthase 3 (has3) as an upregulated gene during caudal fin regeneration. has3 expression is induced in the wound epithelium
Xiaohu Ouyang, Nicholas J Panetta, Maya D Talbott, Alexander Y Payumo, Caroline Halluin, Michael T Longaker, James K Chen   +6 more
doaj   +1 more source

PEGPH20, a PEGylated human hyaluronidase, induces radiosensitization by reoxygenation in pancreatic cancer xenografts. A molecular imaging study

Neoplasia: An International Journal for Oncology Research, 2022
Purpose: PEGylated human hyaluronidase (PEGPH20) enzymatically depletes hyaluronan, an important component of the extracellular matrix, increasing the delivery of therapeutic molecules.
Tomohiro Seki, Yu Saida, Shun Kishimoto, Jisook Lee, Yasunori Otowa, Kazutoshi Yamamoto, Gadisetti VR Chandramouli, Nallathamby Devasahayam, James B. Mitchell, Murali C. Krishna, Jeffery R. Brender   +10 more
doaj   +1 more source

Hyaluronan Metabolism in Human Keratinocytes and Atopic Dermatitis Skin Is Driven by a Balance of Hyaluronan Synthases 1 and 3 [PDF]

Journal of Investigative Dermatology, 2014
Hyaluronan (HA) is a glycosaminoglycan synthesized directly into the extracellular matrix by three hyaluronan synthases (HAS1, HAS2, and HAS3). HA is abundantly synthesized by keratinocytes but its epidermal functions remain unclear. We used culture models to grow human keratinocytes as autocrine monolayers or as reconstructed human epidermis (RHE) to ...
Malaisse, Jérémy, Bourguignon, Virginie, De Vuyst, Evelyne, de Rouvroit, Catherine Lambert; id_orcid 0000-0002-0273-8995, Nikkels, Arjen F, Flamion, Bruno, Poumay, Yves; id_orcid 0000-0001-5200-3367   +6 more
openaire   +3 more sources

Hyaluronan synthase 3 variant and anthracycline-related cardiomyopathy: a report from the children's oncology group. [PDF]

J Clin Oncol, 2014
PurposeThe strong dose-dependent association between anthracyclines and cardiomyopathy is further exacerbated by the co-occurrence of cardiovascular risk factors (diabetes and hypertension). The high morbidity associated with cardiomyopathy necessitates an understanding of the underlying pathogenesis so that targeted interventions can be developed ...
Wang X, Liu W, Sun CL, Armenian SH, Hakonarson H, Hageman L, Ding Y, Landier W, Blanco JG, Chen L, Quiñones A, Ferguson D, Winick N, Ginsberg JP, Keller F, Neglia JP, Desai S, Sklar CA, Castellino SM, Cherrick I, Dreyer ZE, Hudson MM, Robison LL, Yasui Y, Relling MV, Bhatia S.   +25 more
europepmc   +4 more sources

Effect of red ginseng NaturalGEL on skin aging

Journal of Ginseng Research, 2020
Background: In aged skin, degradation of collagen fibers, which occupy the majority of the extracellular matrix in the dermis, and changes of aquaporin 3 (AQP3) and skin constituents, such as hyaluronic acid and ceramide, cause wrinkles and decrease skin
Ye Hyang Kim, Hye Rim Park, So Yoon Cha, So Hun Lee, Jung Wung Jo, Jung Nam Go, Kang Hyuk Lee, Su Yeon Lee, Song Seok Shin   +8 more
doaj   +1 more source

Bacillus subtilis Fermentation Augments the Anti-Inflammatory and Skin Moisture Improvement Activities of Tetragonia tetragonoides through the Upregulation of Antioxidant Components

Fermentation, 2023
This study demonstrates that the fermentation of Tetragonia tetragonioides (T. tetragonioides) by Bacillus subtilis (B. subtilis) subsp. spizizenii enhances its antioxidant, anti-inflammatory, and skin-moisturizing activities. Fermented T. tetragonioides
Hyun Kang, Jin-Woo Hwang, Sung-Gyu Lee
doaj   +1 more source

Differential effects of hyaluronan synthase 3 deficiency after acute vs chronic liver injury in mice. [PDF]

Fibrogenesis Tissue Repair, 2016
Hyaluronan (HA) is a ubiquitous extracellular matrix (ECM) glycosaminoglycan synthesized by three different enzymes, hyaluronan synthase (HAS)1, 2, and 3. HA synthesis mediated by HAS3 promotes inflammation and is pathogenic in animal models of human lung and intestinal disease.
McCracken JM, Jiang L, Deshpande KT, O'Neil MF, Pritchard MT.   +4 more
europepmc   +5 more sources

Knockout of hyaluronan synthase 1, but not 3, impairs formation of the retrocalcaneal bursa [PDF]

Journal of Orthopaedic Research, 2018
ABSTRACTHyaluronan (HA), a high molecular weight non‐sulfated glycosaminoglycan, is an integral component of the extracellular matrix of developing and mature connective tissues including tendon. There are few published reports quantifying HA content during tendon growth and maturation, or detailing its effects on the mechanical properties of the ...
Sikes, Katie J., Renner, Kristen, Li, Jun, Grande‐Allen, K. Jane, Connell, Jennifer P., Cali, Valbona, Midura, Ronald J., Sandy, John D., Plaas, Anna, Wang, Vincent M.   +9 more
openaire   +3 more sources