Results 11 to 20 of about 10,002 (164)

Expression of hyaluronan synthase 3 in deformed human temporomandibular joint discs: in vivo and in vitro studies

European Journal of Histochemistry, 2010
The present study aimed at investigating the expression of a hyaluronan synthase (HAS) 3 in tissue samples of deformed human temporomandibular joint (TMJ) discs and cells obtained from the discs.
T. Matsumoto, M. Inayama, I. Tojyo, N. Kiga, S. Fujita   +4 more
doaj   +4 more sources

CPAP-induced airway hyper-reactivity in mice is modulated by hyaluronan synthase-3. [PDF]

Pediatr Res, 2022
Continuous positive airway pressure (CPAP) is a primary mode of respiratory support for preterm infants. Animal studies have shown long-term detrimental effects on lung/airway development, particularly airway (AW) hyper-reactivity, as an unfortunate consequence of neonatal CPAP. Since the hyaluronan (HA) synthesizing enzyme hyaluronan synthase-3 (HAS3)
Mayer CA, Ganguly A, Mayer A, Pabelick CM, Prakash YS, Hascall VC, Midura RJ, Cali V, Flask CA, Erokwu BO, Martin RJ, MacFarlane PM.   +11 more
europepmc   +3 more sources

Hyaluronan synthase 3 promotes plaque inflammation and atheroprogression. [PDF]

Matrix Biol, 2018
Hyaluronan (HA) is a prominent component of the provisional extracellular matrix (ECM) present in the neointima of atherosclerotic plaques. Here the role of HA synthase 3 (HAS3) in atheroprogression was studied.It is demonstrated here that HAS isoenzymes 1, -2 and -3 are expressed in human atherosclerotic plaques of the carotid artery.
Homann S, Grandoch M, Kiene LS, Podsvyadek Y, Feldmann K, Rabausch B, Nagy N, Lehr S, Kretschmer I, Oberhuber A, Bollyky P, Fischer JW.   +11 more
europepmc   +4 more sources

Role for Hyaluronan Synthase 3 in the Response to Vascular Injury. [PDF]

Arterioscler Thromb Vasc Biol, 2016
More than 1.5 million percutaneous coronary interventions are performed annually. The most important long-term complication is restenosis caused by inflammation, neointimal vascular smooth muscle cell (VSMC) hyperplasia, and excess accumulation of extracellular matrix.
Puré E, Krolikoski M, Monslow J.
europepmc   +4 more sources

Deletion of Hyaluronan Synthase 3 Inhibits Neointimal Hyperplasia in Mice. [PDF]

Arterioscler Thromb Vasc Biol, 2016
Objective— Hyaluronan (HA) is a polymeric glucosaminoglycan that forms a provisional extracellular matrix in diseased vessels. HA is synthesized by 3 different HA synthases (HAS1, HAS2, and HAS3). Aim of this study was to unravel the role of the HAS3 isoenzyme during experimental neointimal hyperplasia.
Kiene LS, Homann S, Suvorava T, Rabausch B, Müller J, Kojda G, Kretschmer I, Twarock S, Dai G, Deenen R, Hartwig S, Lehr S, Köhrer K, Savani RC, Grandoch M, Fischer JW.   +15 more
europepmc   +4 more sources

Epidermal keratinocytes regulate hyaluronan metabolism via extracellularly secreted hyaluronidase 1 and hyaluronan synthase 3. [PDF]

J Biol Chem
Hyaluronan (HA) is a high-molecular-weight (HMW) glycosaminoglycan, which is a fundamental component of the extracellular matrix that is involved in a variety of biological processes. We previously showed that the HYBID/KIAA1199/CEMIP axis plays a key role in the depolymerization of HMW-HA in normal human dermal fibroblasts (NHDFs).
Abe M, Masuda M, Mizukami Y, Inoue S, Mizutani Y.   +4 more
europepmc   +4 more sources

Accumulation of extracellular hyaluronan by hyaluronan synthase 3 promotes tumor growth and modulates the pancreatic cancer microenvironment. [PDF]

Biomed Res Int, 2014
Extensive accumulation of the glycosaminoglycan hyaluronan is found in pancreatic cancer. The role of hyaluronan synthases 2 and 3 (HAS2, 3) was investigated in pancreatic cancer growth and the tumor microenvironment. Overexpression of HAS3 increased hyaluronan synthesis in BxPC-3 pancreatic cancer cells.
Kultti A, Zhao C, Singha NC, Zimmerman S, Osgood RJ, Symons R, Jiang P, Li X, Thompson CB, Infante JR, Jacobetz MA, Tuveson DA, Frost GI, Shepard HM, Huang Z.   +14 more
europepmc   +4 more sources

Hyaluronan Synthase 3 Regulates Hyaluronan Synthesis in Cultured Human Keratinocytes [PDF]

Journal of Investigative Dermatology, 2002
Three human hyaluronan synthase genes (HAS1, HAS2, and HAS3) have been cloned, but the functional differences between these HAS genes remains obscure. The purpose of this study was to examine which of the HAS genes are selectively regulated in epidermis.
Sayo, Tetsuya, Sugiyama, Yoshinori, Takahashi, Yoshito, Ozawa, Naoko, Sakai, Shingo, Inoue, Shintaro, Ishikawa, Osamu, Tamura, Masaaki   +7 more
openaire   +2 more sources

Recombinant human hyaluronan synthase 3 is phosphorylated in mammalian cells [PDF]

Biochemical Journal, 2006
Hyaluronan is a ubiquitous component of vertebrate extracellular and cell-associated matrices that serves as a key structural component of skin, cartilage, eyes and joints, and plays important roles in dynamic cellular processes, including embryogenesis, inflammation, wound healing and metastasis.
Brian J, Goentzel, Paul H, Weigel, Robert A, Steinberg   +2 more
openaire   +2 more sources

The Role of Hyaluronan Synthase 3 in Ventilator-induced Lung Injury [PDF]

American Journal of Respiratory and Critical Care Medicine, 2005
Abstract We recently found that low-molecular-weight hyaluronan was induced by cyclic stretch in lung fibroblasts and accumulated in lungs from animals with ventilator-induced lung injury. The low-molecular-weight hyaluronan produced by stretch increased interleukin-8 production in epithelial cells, and was accompanied by an ...
Kuan-Jen, Bai, Andrew P, Spicer, Marcella M, Mascarenhas, Lunyin, Yu, Cristhiaan D, Ochoa, Hari G, Garg, Deborah A, Quinn   +6 more
openaire   +2 more sources