Results 171 to 180 of about 10,976 (205)
International Journal of Cancer, 2002 Advanced colorectal cancers are often associated with elevated amounts of hyaluronan. To investigate the importance of hyaluronan in colon carcinoma tumor progression, we have expressed by stable transfection hyaluronan synthase 2 (Has2) and ...
Kristofer Rubin, Paraskevi Heldin
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Analysis of Hyaluronan Synthase Activity
2014Hyaluronan (HA) is a component of the extracellular matrix that is involved in many physiological and pathological processes. As HA modulates several functions (i.e., cell proliferation and migration, inflammation), its presence in the tissues can have positive or negative effects.
Davide, Vigetti +3 more
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Hyaluronan and hyaluronan synthases expression and localization in embryonic mouse molars
Journal of Molecular Histology, 2016Hyaluronan (HA) and hyaluronan synthases (HASs) have been shown to play critical roles in embryogenesis and organ development. However, there have not been any studies examining HA and HAS expression and localization during tooth development. The present study was designed to investigate the expression of HA and three isoforms of HASs (HAS1, 2, 3) in ...
Guofeng, Yang +4 more
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Hyaluronan synthase expression in ovarian cancer
Oncology Reports, 2004To determine if the immunohistochemical expression of hyaluronan synthase (HAS) correlates with the clinicopathological manifestations or clinical outcomes of ovarian carcinoma, sections of tumor tissue from 33 ovarian cancer patients were immunostained by the avidin-biotin-peroxidase complex method using anti-HAS1, anti-HAS2, anti-HAS3 and anti-CD44 ...
Hiromitsu, Yabushita +7 more
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Hyaluronan Synthases Posttranslational Regulation in Cancer
2014Hyaluronan (HA) is a critical component of cancer microenvironment that is known to increase tumor progression and aggressiveness. The synthesis of HA starts from the cytosolic precursors UDP-N-acetylglucosamine and UDP-glucuronic acid. These two sugar nucleotides have several functions in addition to glycoconjugate synthesis and glucuronidation ...
VIGETTI, DAVIDE, PASSI, ALBERTO
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Hyaluronan synthases and hyaluronidases in nasal polyps
European Archives of Oto-Rhino-Laryngology, 2015Nasal polyps (NPs) are benign lesions of nasal and paranasal sinuses mucosa affecting 1-4 % of all adults. Nasal polyposis affects the quality of patient's life as it causes nasal obstruction, postnasal drainage, purulent nasal discharge, hyposmia or anosmia, chronic sinusitis, facial pain and snoring.
T, Panogeorgou +7 more
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Molecular Cloning of Human Hyaluronan Synthase
Biochemical and Biophysical Research Communications, 1996We report here the cDNA sequence of human hyaluronan synthase. The cDNA clone was isolated from a human fetal brain cDNA library by screening with a DNA probe generated from the coding sequence of murine hyaluronan synthase. It contains a 2107 bp cDNA insert which is composed of a 1629 bp open reading frame and a short segment of the 3'-untranslated ...
N, Itano, K, Kimata
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Therapeutic roles of hyaluronan and synthases in cartilage
Trends in Molecular MedicineHyaluronan synthases (HASs) are essential enzymes for hyaluronic acid (HA) production; a key component for joint lubrication and cartilage health. Dysregulated HA synthesis contributes to joint dysfunction. In this Forum, we discuss the role of HAS in matrix assembly, inflammation and the pathogenesis of osteoarthritis (OA).
Gengyun, Le-Chan +4 more
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2009
Hyaluronan (HA) is a polysaccharide composed of repeating GlcNAcβ(1 → 4)- GlcUAβ(1 → 3) disaccharide units. This polysaccharide has a molecular mass ranging from 103 to 107 Da, depending on the tissue source and physiological conditions. Three members of the HA synthase family, HAS1, HAS2 and HAS3, have been thus far identified in a wide variety of ...
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Hyaluronan (HA) is a polysaccharide composed of repeating GlcNAcβ(1 → 4)- GlcUAβ(1 → 3) disaccharide units. This polysaccharide has a molecular mass ranging from 103 to 107 Da, depending on the tissue source and physiological conditions. Three members of the HA synthase family, HAS1, HAS2 and HAS3, have been thus far identified in a wide variety of ...
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Expression of hyaluronan synthases and hyaluronan in malignant mesothelioma cells.
Anticancer research, 2004Hyaluronan is one of the main components of the extracellular matrix. It is synthesized at the cell plasma membrane by specific hyaluronan synthases (HAS). Although a large number of studies have described hyaluronan in pleural effusion from malignant mesothelioma, the source of hyaluronan in malignant mesothelioma has been subject to controversy.The ...
Zhiwen, Liu +3 more
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