Type-3 Hyaluronan Synthase Attenuates Tumor Cells Invasion in Human Mammary Parenchymal Tissues [PDF]
Molecules, 2021 The microenvironment for tumor growth and developing metastasis should be essential. This study demonstrated that the hyaluronic acid synthase 3 (HAS3) protein and its enzymatic product hyaluronic acid (HA) encompassed in the subcutaneous extracellular ...
Wen-Jui Lee +11 more
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4-Methylumebelliferone Enhances Radiosensitizing Effects of Radioresistant Oral Squamous Cell Carcinoma Cells via Hyaluronan Synthase 3 Suppression [PDF]
Cells, 2022 Radioresistant (RR) cells are poor prognostic factors for tumor recurrence and metastasis after radiotherapy. The hyaluronan (HA) synthesis inhibitor, 4-methylumbelliferone (4-MU), shows anti-tumor and anti-metastatic effects through suppressing HA ...
Kazuki Hasegawa +9 more
doaj +2 more sources
Hyaluronic acid production and characterization by novel Bacillus subtilis harboring truncated Hyaluronan Synthase [PDF]
AMB Express, 2022 Key points The strains containing truncated forms of SeHAS enzysme are able to produce HA. The HA from all recombinant strains was the same and low Mw. Deletion of C-terminal region of SeHAS was not effective on Mw.
Fatemeh Sadat Amjad Zanjani +7 more
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Hyaluronan synthase 1 (HAS1): A mysterious enzyme with unexpected functions [PDF]
Frontiers in Immunology, 2015 Hyaluronan synthase 1 (HAS1) is one of three isoenzymes responsible for cellular hyaluronan synthesis. Interest in HAS1 has been limited because its role in hyaluronan production seems to be insignificant compared to the two other isoenzymes, HAS2 and ...
Hanna eSiiskonen +3 more
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Nanotherapy in Joints: Increasing Endogenous Hyaluronan Production by Delivering Hyaluronan Synthase 2 [PDF]
Advanced Materials, 2019 AbstractOsteoarthritis (OA) is a common joint degenerative disease that causes pain, joint damage, and dysfunction. External hyaluronic acid (HA) supplement is a common method for the management of osteoarthritis which requires multi‐injections. It is demonstrated that biodegradable mesoporous silica nanoparticles successfully deliver an enzyme ...
Huimin Li +11 more
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Natural Antisense mRNAs to Hyaluronan Synthase 2 Inhibit Hyaluronan Biosynthesis and Cell Proliferation [PDF]
Journal of Biological Chemistry, 2005 We report the identification of a natural antisense mRNA of hyaluronan synthase 2 that we have chosen to designate as HASNT (for HA synthase 2 antisense) in human and mouse. HASNT is transcribed from the opposite strand of the HAS2 gene locus and is represented by several independent expressed sequence tags in human.
Hsu‐Wen Chao, Andrew P. Spicer
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Hyaluronan synthase 2-mediated hyaluronan production mediates Notch1 activation and liver fibrosis. [PDF]
Sci Transl Med, 2019 Hepatic stellate cells activated by hyaluronan synthase 2–mediated hyaluronan and Notch1 promote liver fibrosis, identifying a potential target.
Yang YM +19 more
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Melatonin promotes neuroblastoma cell differentiation by activating hyaluronan synthase 3‐induced mitophagy [PDF]
Cancer Medicine, 2019 Neuroblastoma is the second most common pediatric malignancy and has a high rate of spontaneous remission. Uncovering the mechanisms underlying neuroblastoma cell differentiation is critical for therapeutic purposes.
Wen‐Jui Lee +8 more
doaj +2 more sources
Cancer-Associated Fibroblasts Move and Interact More with Triple-Negative Breast Cancer Cells and Stimulate Their Proliferation in a Hyaluronan-Dependent Manner [PDF]
CellsWhile normal fibroblasts suppress tumor growth, during cancer initiation and progression, this capacity can be lost and even switched to tumor-promoting, for reasons that are not understood.
Sz-Ying Hou +7 more
doaj +2 more sources
Hyaluronan synthase 2 expressed by cancer-associated fibroblasts promotes oral cancer invasion [PDF]
Journal of Experimental & Clinical Cancer Research, 2016 Background Hyaluronan synthases (HAS) control the biosynthesis of hyaluronan (HA) and critically modulate the tumor microenviroment. Cancer-associated fibroblasts (CAFs) affect the progression of a tumor by remolding the matrix.
Ziwen Zhang +8 more
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