Results 61 to 70 of about 87,553 (215)

Effect of modulating the extracellular matrix cross linkage by genipin on tumor cell resistance and survival in thioacetamide-induced hepatocellular carcinoma in rats [PDF]

PeerJ
Background Previous studies on patients and rats with hepatocellular carcinoma (HCC) have shown significant changes in the extracellular matrix (ECM). Versican, a component of the ECM, forms extensive multimolecular interactions with other ECM components,
Hanan M. Hassan, Mohammed Baradwan, Alaa Bagalagel, Reem Diri, Ahmed Basilim, Mohammed Z. Nasrullah, Abdulhamid Althagafi, Hussam I. Kutbi, Abdulaziz A. Mohammed, Hanan M. Alshan, Mohammed M.H. Al-Gayyar   +10 more
doaj   +2 more sources

Dynamic interplay between breast cancer cells and normal endothelium mediates the expression of matrix macromolecules, proteasome activity and functional properties of endothelial cells [PDF]

, 2014
Background Breast cancer\u2013endothelium interactions provide regulatory signals facilitating tumor progression. The endothelial cells have so far been mainly viewed in the context of tumor perfusion and relatively little is known regarding the effects ...
Barbouri, D., Gialeli, C., Karamanos, N.K., Kletsas, D., Passi, A., Viola, M.   +5 more
core   +1 more source

Knockout of hyaluronan synthase 1, but not 3, impairs formation of the retrocalcaneal bursa [PDF]

Journal of Orthopaedic Research, 2018
ABSTRACTHyaluronan (HA), a high molecular weight non‐sulfated glycosaminoglycan, is an integral component of the extracellular matrix of developing and mature connective tissues including tendon. There are few published reports quantifying HA content during tendon growth and maturation, or detailing its effects on the mechanical properties of the ...
Sikes, Katie J., Renner, Kristen, Li, Jun, Grande‐Allen, K. Jane, Connell, Jennifer P., Cali, Valbona, Midura, Ronald J., Sandy, John D., Plaas, Anna, Wang, Vincent M.   +9 more
openaire   +3 more sources

Hyaluronan synthase 2 expressed by cancer-associated fibroblasts promotes oral cancer invasion

Journal of Experimental & Clinical Cancer Research, 2016
Background Hyaluronan synthases (HAS) control the biosynthesis of hyaluronan (HA) and critically modulate the tumor microenviroment. Cancer-associated fibroblasts (CAFs) affect the progression of a tumor by remolding the matrix.
Ziwen Zhang, Detao Tao, Ping Zhang, Xue Liu, Yuchao Zhang, Jie Cheng, Hua Yuan, Laikui Liu, Hongbing Jiang   +8 more
doaj   +1 more source

The use of pituitary adenylate cyclase-activating polypeptide in the pre-maturation system improves in vitro developmental competence from small follicles of porcine oocytes [PDF]

Asian-Australasian Journal of Animal Sciences, 2019
Objective We investigated how pituitary adenylate cyclase-activating polypeptide (PACAP) affects embryonic development during pre-in vitro maturation (pre-IVM) using porcine oocytes isolated from small follicles. Methods We divided the follicles into the
Kyu-Mi Park, Kyu-Jun Kim, Minghui Jin, Yongquan Han, Kyoung-Ha So, Sang-Hwan Hyun   +5 more
doaj   +1 more source

Doxycycline inhibits inflammation-induced lymphangiogenesis in mouse cornea by multiple mechanisms. [PDF]

PLoS ONE, 2014
Lymphangiogenesis is significantly involved in the pathogenesis of diseases, including graft rejection, cancer metastasis and various inflammatory conditions.
Longhui Han, Wenru Su, Jingwen Huang, Jingwen Zhou, Sujuan Qiu, Dan Liang   +5 more
doaj   +1 more source

Bench-to-bedside review: The role of glycosaminoglycans in respiratory disease. [PDF]

, 2006
The extracellular matrix (ECM) plays a significant role in the mechanical behaviour of the lung parenchyma. The ECM is composed of a three-dimensional fibre mesh that is filled with various macromolecules, among which are the glycosaminoglycans (GAGs ...
PELOSI P.P., ROCCO PR, SOUZA-FERNANDES AB   +2 more
core   +1 more source

The potential for dietary factors to prevent or treat osteoarthritis [PDF]

, 2014
Osteoarthritis (OA) is a degenerative joint disease for which there are no disease-modifying drugs. It is a leading cause of disability in the UK. Increasing age and obesity are both major risk factors for OA and the health and economic burden of this ...
Bao, Yongping, Cassidy, Aedín, Clark, Ian M., Davidson, Rose K., Donell, Simon T., Green, Jonathan A., Hirst-Jones, Kimberley L., Jupp, Orla, Macgregor, Alexander J.   +8 more
core   +1 more source

Antiemesis Corticosteroids Potentiate Checkpoint Blockade Efficacy by Normalizing the Immune Microenvironment in Metastatic Murine Breast Cancer

Advanced Science, EarlyView.
Corticosteroids improve the efficacy of immune checkpoint blockade therapy in metastatic murine breast cancer. By normalizing the tumor immune microenvironment, corticosteroids reduce immunosuppressive signals, restore T‐cell function, and promote antitumor immune responses, resulting in enhanced tumor control.
John D. Martin, Koji Nagaoka, Myrofora Panagi, Akihiro Hosoi, Fotios Mpkeris, Pengwen Chen, Thahomina T. Khan, Margaret R. Martin, Changbo Sun, Chrysovalantis Voutouri, Maria Louca, Panagiotis Papageorgis, Akira Sumiyoshi, Nobuhiro Nitta, Kazuyoshi Takeda, Ichio Aoki, Kazunori Kataoka, Triantafyllos Stylianopoulos, Kazuhiro Kakimi, Horacio Cabral   +19 more
wiley   +1 more source

Protein glycosylation in lung cancer from a mass spectrometry perspective

Mass Spectrometry Reviews, EarlyView.
Abstract Lung cancer is a severe disease for which better diagnostic and therapeutic approaches are urgently needed. Increasing evidence implies that aberrant protein glycosylation plays a crucial role in the pathogenesis and progression of lung cancer.
Mirjam Balbisi, Simon Sugár, Lilla Turiák   +2 more
wiley   +1 more source