Results 81 to 90 of about 8,263 (198)

The E‐cadherin‐Wnt‐mir‐994 Axis Repurposes a Cadherin Switch for Niche Robustness and Germline Stem Cell Maintenance

Cell Proliferation, EarlyView.
In the Drosophila ovarian niche, an E‐cadherin‐to‐N‐cadherin switch, mediated by Wnt‐mir‐994 signalling, is repurposed to ensure niche resilience. This compensatory mechanism maintains niche integrity and stem cell support upon E‐cadherin loss, revealing a robustness circuit.
Renjun Tu, Hiu Laam Yau, Runzhi Deng, Sarah E. Webb, Shiyuan Chen, Jianquan Ni, Ting Xie   +6 more
wiley   +1 more source

Generation of a murine monoclonal antibody to capsular polysaccharide Vi from Salmonella Typhi

VacciMonitor, 2015
The conventional hybridoma technology has enabled the development of monoclonal antibodies (Mabs) against many antigens. Mabs have several applications in the field of basic research, diagnosis, immunotherapy and vaccine manufacturing processes. Mabs-
Fátima Reyes-López, Frank Camacho-Casanova, Oscar Otero-Alfaro, Maribel Cuello-Pérez, Darcy Núñez-Martínez, Sonsire Fernández-Castillo, Luis Guillermo García-Imía   +6 more
doaj  

Toxicity of Mercury to Hybridoma TA7 Cells [PDF]

, 1999
Environmental mercury and mercury compound contamination has increased dramatically since the industrial revolution. This paper describes the toxic effects of mercury on a culture of hybridoma TA7 cells, which produce antibodies against the A-subunit of ...
Hackel Veksler, Andersons, Pauls, Inessa Remez, Remez, Inessa, Veksler, Hackel, Pauls Andersons   +5 more
core   +1 more source

TOP1MT rs2293925 is an enhancer‐active regulatory SNP that shapes mitochondrial R‐loop dynamics

The FEBS Journal, EarlyView.
This study shows how a common genetic variant of mitochondrial topoisomerase 1 (TOP1MT rs2293925) can influence mitochondrial gene regulation, DNA topology, and formation of noncanonical nucleic acid structures such as R‐loops. By linking this enhancer‐active variant to mitochondrial nucleic acid stress in cellular contexts relevant to amyotrophic ...
Dóra Varga, Zsolt Ráduly, Beáta Boros‐Oláh, Éva Nagy, Zsolt Karányi, László Halász, Bálint László Bálint, György Vámosi, Emese Tóth, Péter Bai, Serena Santangelo, Patrizia Bossolasco, Antonia Ratti, Vincent Géli, Yves Pommier, Lóránt Székvölgyi   +15 more
wiley   +1 more source

Generation of the first TCR transgenic mouse with CD4+ T cells recognizing an anti-inflammatory regulatory T cell-inducing HSP70 peptide

Frontiers in Immunology, 2016
Antigen-specific regulatory T cells (Tregs) directed at self-antigens are difficult to study since suitable specific tools to isolate and characterize these cells are lacking. A T cell receptor (TCR)-transgenic mouse would generate possibilities to study
Manon AA Jansen, Martijn JC Van Herwijnen, Peter JS van Kooten, Aad eHoek, Ruurd eVan Der Zee, Willem eVan Eden, Femke eBroere   +6 more
doaj   +1 more source

Myo1g Mediates NKR‐P1C Expression in Primary Mouse NK Cells and Participates in Cytotoxicity

Immunology, EarlyView.
In this study we analysed the participation of Myosin 1g in the development and functions of murine natural killer (NK) cells; we found that Myosin 1g is expressed in murine‐activated primary NK cells from the spleen. Additionally, in the absence of Myosin 1g, correlates with a reduced expression of NKR‐P1C but not of CD49b or NKp46.
Héctor Romero‐Ramírez, Vania Aminta Zuleica López‐Esparza, Mariana Flores‐Castelán, Leopoldo Santos‐Argumedo   +3 more
wiley   +1 more source

Updates on the production of therapeutic antibodies using human hybridoma technique

, 2016
Therapeutic antibodies are implicated into the very promising and fast growing area of pharmaceutics. Human hybridoma technology, allowing generation of natural human antibodies in a native form, seems to be the most direct way that require no additional
Zaripov M.M., Glukhov A.S., Prusakova O.V., Avila-Rodriguez M., Glukhova X.A., Trizna J.A., Barreto, George, Aliev G., Poltavtseva R.A., Ivanov A.A., Afanas’Eva G.V., Beletsky I.P.   +11 more
core   +1 more source

Ocular Manifestations of Infectious Salmon Anaemia Virus Infection in Atlantic Salmon (Salmo salar)

Journal of Fish Diseases, EarlyView.
ABSTRACT Eyes are essential sensory organs needed by teleost Atlantic salmon for high visual acuity and survival in both the wild and in aquaculture settings. In this work, we assessed the ocular manifestations of Infectious Salmon Anaemia Virus (ISAV) infection in Atlantic salmon by a cohabitation‐mediated infection assay and histological and ...
Emily Mahon, Rebecca R. Kwabiah, Hélène Paradis, Manuel A. Soto‐Dávila, Sathees Duglas, Raja Ram Gurung, Thurka Paramanathan, Ignacio Vasquez, Shams Al‐Badoosh, John Law, Javier Santander, Mark D. Fast, Robert L. Gendron   +12 more
wiley   +1 more source

Advances in the Isolation of Specific Monoclonal Rabbit Antibodies

Frontiers in Immunology, 2017
The rabbit monoclonal antibodies (mAbs) have advantages in pharmaceuticals and diagnostics with high affinity and specificity. During the past decade, many techniques have been developed for isolating rabbit mAbs, including single B cell antibody ...
Zaibao Zhang, Zaibao Zhang, Huijuan Liu, Huijuan Liu, Qian Guan, Lei Wang, Lei Wang, Hongyu Yuan, Hongyu Yuan   +8 more
doaj   +1 more source

Establishment of a procedure for producing the anti-b monoclonal antibody from B4C10D9 hybridoma cell line

, 2017
There are two the most important blood group system in blood transfusion, that is the ABO system and the Rh system. The anti-A or anti-B antibodies in the blood of recipient cause strongly agglutination the red blood cells of donor bearing A or B ...
Nguyen Thi Trung, Truong Nam Hai
core   +1 more source