Results 1 to 10 of about 59,780 (293)

Human endothelial culture supernatant (HECS): a growth factor for hybridomas. [PDF]

open access: bronzeJournal of Immunology, 1980
Human endothelial culture supernatant (HECS) had strong growth-promotion activity for hybridoma cells: the yield of hybridomas after fusion was increased at least 2-fold over that in the presence of feeder cells, such as mouse macrophages and spleen ...
G Astaldi   +5 more
openalex   +2 more sources

Production of a T cell hybridoma that expresses the T cell receptor gamma/delta heterodimer. [PDF]

open access: bronze, 1987
We have produced a T cell hybridoma line by fusion of an IL-2-dependent, long-term T cell receptor (TCR) gamma/delta+ Thy-1+, bone marrow-derived, dendritic epidermal cell line to the BW5147 tumor line.
Wayne M. Yokoyama   +5 more
openalex   +4 more sources

Antigen-specific identification and cloning of hybridomas with a fluorescence-activated cell sorter.

open access: greenProceedings of the National Academy of Sciences of the United States of America, 1979
David R. Parks   +3 more
openalex   +2 more sources

When monoclonal antibodies are not monospecific: Hybridomas frequently express additional functional variable regions

open access: yesmAbs, 2018
Monoclonal antibodies are commonly assumed to be monospecific, but anecdotal studies have reported genetic diversity in antibody heavy chain and light chain genes found within individual hybridomas.
A. Bradbury   +24 more
semanticscholar   +1 more source

Characterization of the T cell receptor repertoire causing collagen arthritis in mice [PDF]

open access: yes, 1993
Collagen type II-induced arthritis (CIA) is generated in susceptible rodent strains by intradermal injections of homologous or heterologous native type II collagen in complete Freund's adjuvant.
Hood, Leroy E.   +3 more
core   +2 more sources

Antigen-inducible, H-2-restricted, interleukin-2-producing T cell hybridomas. Lack of independent antigen and H-2 recognition

open access: yesJournal of Experimental Medicine, 1981
We developed a method for production of antigen-specific, H-2-restricted T cell hybrids. The tumor cell partner in the fusions was itself a T cell hybrid, FS6-14.13.AG2 (or its derivatives), which could be induced to produce the growth factor ...
J. Kappler   +3 more
semanticscholar   +1 more source

Hybrid cell lines producing monoclonal antibodies directed against Treponema [PDF]

open access: yes, 1985
Continuous hybrid cell lines for producing monoclonal antibodies directed against antigens of Treponema pallidum have been developed. The hybrid cell lines were established by fusing differentiated lymphoid cells primed with antigens of Treponema ...
Kettman, John R., Norgard, Michael V.
core   +1 more source

Monoclonal antibodies against human astrocytomas and their reactivity pattern [PDF]

open access: yes, 1987
The establishment of hybridomas after fusion of X63-Ag8.653 mouse myeloma cells and splenocytes from mice hyperimmunized against human astrocytomas is presented. The animals were primed with 5 × 106 chemically modified uncultured or cultured glioma cells.
B. Martin   +36 more
core   +1 more source

Class-switched anti-insulin antibodies originate from unconventional antigen presentation in multiple lymphoid sites [PDF]

open access: yes, 2016
Autoantibodies to insulin are a harbinger of autoimmunity in type 1 diabetes in humans and in non-obese diabetic mice. To understand the genesis of these autoantibodies, we investigated the interactions of insulin-specific T and B lymphocytes using T ...
Acevedo-Suárez   +59 more
core   +2 more sources

Posttranslational association of immunoglobulin heavy chain binding protein with nascent heavy chains in nonsecreting and secreting hybridomas

open access: yesJournal of Cell Biology, 1986
A rat monoclonal antibody specific for immunoglobulin (Ig) heavy chain binding protein (BiP) has allowed the examination of the association of BiP with assembling Ig precursors in mouse B lymphocyte-derived cell lines.
D. Bole, L. Hendershot, J. Kearney
semanticscholar   +1 more source

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