Results 91 to 100 of about 59,454 (330)

Sponge Hybridomas: Applications and Implications [PDF]

Integrative and Comparative Biology, 2013
Many sponge-derived natural products with applications to human health have been discovered over the past three decades. In vitro production has been proposed as one biological alternative to ensure adequate supply of marine natural products for preclinical and clinical development of drugs. Although primary cell cultures have been established for many
Pomponi, S.A., Jevitt, A., Patel, J., Diaz, M.C.   +3 more
openaire   +3 more sources

3D Mitochondrial Structure in Aging Human Skeletal Muscle: Insights Into MFN‐2‐Mediated Changes

Aging Cell, EarlyView.
Changes in mitochondrial structure and dynamics during aging provide a mechanism for the development of age‐related sarcopenia, a condition characterized by muscle mass loss. Through the creation of three‐dimensional models of mitochondria from quadriceps muscle tissue taken from old and young humans, a loss in mitochondrial complexity was observed to ...
Estevão Scudese, Andrea G. Marshall, Zer Vue, Vernat Exil, Benjamin I. Rodriguez, Mert Demirci, Larry Vang, Edgar Garza López, Kit Neikirk, Bryanna Shao, Han Le, Dominique Stephens, Duane D. Hall, Rahmati Rostami, Taylor Rodman, Kinuthia Kabugi, Jian‐qiang Shao, Margaret Mungai, Salma T. AshShareef, Innes Hicsasmaz, Sasha Manus, Celestine N. Wanjalla, Aaron Whiteside, Revathi Dasari, Clintoria R. Williams, Steven M. Damo, Jennifer A. Gaddy, Brian Glancy, Estélio Henrique Martin Dantas, André Kinder, Ashlesha Kadam, Dhanendra Tomar, Fabiana Scartoni, Matheus Baffi, Melanie R. McReynolds, Mark A. Phillips, Anthonya Cooper, Sandra A. Murray, Anita M. Quintana, Nelson Wandira, Okwute M. Ochayi, Magdalene Ameka, Annet Kirabo, Sepiso K. Masenga, Chanel Harris, Ashton Oliver, Pamela Martin, Amadou Gaye, Olga Korolkova, Vineeta Sharma, Bret C. Mobley, Prasanna Katti, Antentor Hinton   +52 more
wiley   +1 more source

Antigen presentation by Ia+ B cell hybridomas to H-2-restricted T cell hybridomas.

Proceedings of the National Academy of Sciences of the United States of America, 1982
The Ia+, H-2d BALB/c lymphoma cell line L10.A 2J was fused to T cell-depleted spleen cells from mouse strains bearing other H-2 haplotypes. A portion of the selected hybrids expressed Ia antigens of the normal spleen cell partner in the fusion as ...
J. Kappler, J. White, D. Wegmann, E. Mustain, P. Marrack   +4 more
semanticscholar   +1 more source

Dual Inhibition of Mast Cells and Thymic Stromal Lymphopoietin Using a Novel Bispecific Antibody, CDX‐622

Allergy, EarlyView.
SCF and TSLP expression are known to drive unique immune responses leading to the onset of allergic and inflammatory diseases. Here, we describe the characterization of a novel bsAb, CDX‐622, that targets SCF and TSLP. CDX‐622 inhibits MC functions through SCF starvation and Type 2 inflammatory responses via TSLP inhibition.
Michael B. Murphy, Laura Vitale, Thomas O'Neill, Deena M. Maurer, Linda Malenchek, Andrea Crocker, Colleen Patterson, Laura Mills‐Chen, Virginia Saley, Nicole M. Antczak, James M. Boyer, Kelly M. McManus, Noe Rico Montanari, Russell A. Hammond, Joel Goldstein, Lawrence J. Thomas, Tibor Keler, Diego Alvarado   +17 more
wiley   +1 more source

T cell receptor-dependent cell death of T cell hybridomas mediated by the CD30 cytoplasmic domain in association with tumor necrosis factor receptor-associated factors

Journal of Experimental Medicine, 1996
CD30 is a member of the tumor necrosis factor superfamily and a surface marker for Hodgkin's disease. Normal activated T cells and several virally transformed T or B cell lines also show CD30 expression.
Soo-Young Lee, Chae Gyu Park, Yong-Sun Choi   +2 more
semanticscholar   +1 more source

MUSTN1 Interaction With SMPX Regulates Muscle Development and Regeneration

Cell Proliferation, EarlyView.
Model of the role of MUSTN1 in skeletal muscle development. MUSTN1‐KO mice display delayed muscle growth and regeneration. MUSTN1 protects SMPX from instability and maintains the morphology of muscle fibres. MUSTN1 and SMPX synergistically promote myoblast proliferation and dependently facilitate differentiation.
Yu Fu, Xin Hao, Peng Shang, Jingru Nie, Yangzom Chamba, Bo Zhang, Hao Zhang   +6 more
wiley   +1 more source

Human hybridomas constructed with antigen-specific Epstein-Barr virus-transformed cell lines.

Proceedings of the National Academy of Sciences of the United States of America, 1982
A 6-thioguanine-resistant, human lymphoblastoid B-cell line (GM1500 6TG A-11; IgG secreting) was mutagen-treated with low-level gamma-irradiation and selected for ouabain resistance.
D. Kozbor, A. Lagarde, J. Roder
semanticscholar   +1 more source

PCSK9 and coronary atherosclerosis progression beyond LDL‐cholesterol in coronary artery disease patients

European Journal of Clinical Investigation, EarlyView.
In a population of patients with stable CAD, circulating levels of PCSK9 are independently associated with the progression of adverse coronary plaque phenotypes, as assessed by serial coronary computed tomography angiography. At RNA‐seq analysis of whole blood, PCSK9 was linked to the expression of genes involved in the innate‐immune response.
Rosetta Ragusa, Silvia Rocchiccioli, Serena Del Turco, Antonio Morlando, Giuseppina Basta, Arthur Scholte, Danilo Neglia, Chiara Caselli   +7 more
wiley   +1 more source

Monoclonal Antibodies against the Drosophila Nervous System [PDF]

, 1982
A panel of 148 monoclonal antibodies directed against Drosophila neural antigens has been prepared by using mice immunized with homogenates of Drosophila tissue. Antibodies were screened immunohistochemically on cryostat sections of fly heads.
Benzer, Seymour, Ferrús, Alberto, Fujita, Shinobu C., Shotwell, Sandra L., Zipursky, Stephen L.   +4 more
core   +1 more source

Activation-induced cell death in murine T cell hybridomas. Differential regulation of Fas (CD95) versus Fas ligand expression by cyclosporin A and FK506.

International Immunology, 1996
We have previously reported that activation of murine T cell hybridomas leads to expression of Fas (CD95) and its ligand (FasL) which subsequently interact, even on the same cell, leading to apoptotic cell death.
Thomas Brunner, Nam Jin Yoo, D. Laface, Carl F. Ware, Douglas R. Green   +4 more
semanticscholar   +1 more source