Results 131 to 140 of about 59,454 (330)

Cotransfer of the Eαd and Aβd genes into L cells results in the surface expression of a functional mixed-isotype Ia molecule [PDF]

, 1986
Ia molecules play a key role in antigen recognition by T lymphocytes. To analyze the structural features of the individual α and β chains relevant to the assembly of intact Ia molecules, mouse fibroblasts were contransfected with various combinations of ...
Hood, Leroy, Malissen, Bernard, Pierres, Michel, Shastri, Nilabh   +3 more
core  

Neuromuscular junction instability with inactivity: morphological and functional changes after 10 days of bed rest in older adults

The Journal of Physiology, EarlyView.
Abstract figure legend This figure summarises the study of neuromuscular junction (NMJ) changes in 10 older males following a 10 day bed rest period. Baseline (BR0) and post‐bed rest (BR10) assessments were conducted using intramuscular EMG (iEMG) to measure NMJ transmission. At BR0 and BR10, muscle biopsies were obtained to analyse NMJ morphology, and
Evgeniia Motanova, Fabio Sarto, Samuele Negro, Marco Pirazzini, Ornella Rossetto, Michela Rigoni, Daniel W. Stashuk, Mladen Gasparini, Boštjan Šimunic, Rado Pišot, Marco V. Narici   +10 more
wiley   +1 more source

Bispecific antibodies and their use in applied research

Veterinary World, 2012
Bispecific antibodies (BsAb) can, by virtue of combining two binding specificities, improve the selectivity and efficacy of antibody-based treatment of human disease.
Harshit Verma, Durairajan Ramachandran, Ashabaree Samal   +2 more
doaj   +1 more source

α-Lactosylceramide Protects Against iNKT-Mediated Murine Airway Hyperreactivity and Liver Injury Through Competitive Inhibition of Cd1d Binding. [PDF]

, 2019
Invariant natural killer T (iNKT) cells, which are activated by T cell receptor (TCR)-dependent recognition of lipid-based antigens presented by the CD1d molecule, have been shown to participate in the pathogenesis of many diseases, including asthma and ...
Chang, Ya-Jen, Chi, Po-Yu, Gervay-Hague, Jacquelyn, Han, Yun-Chiann, Hsieh, Hsiao-Wu, Kao, Hsien-Neng, Lai, Alan Chuan-Ying, Thio, Christina Li-Ping   +7 more
core  

Inhibition of Influenza-Immune T Cell Effector Function by Virus-Specific Hybridoma Antibody [PDF]

, 1979
Rita B. Effros, Mark Frankel, Walter Gerhard, Peter C. Doherty   +3 more
openalex   +1 more source

Role of reactive oxygen intermediates in TCR-induced death of T cell blasts and hybridomas.

Journal of Immunology, 1996
The functional role of reactive oxygen intermediates (ROI) in activation-induced death of mature T lymphocytes and hybridomas was tested using antioxidants and inhibitors of enzymes that generate oxidants. These agents were shown to inhibit TCR-triggered
M. S. Williams, P. Henkart
semanticscholar   +1 more source

Antioxidant supplementation blunts the proteome response to 3 weeks of sprint interval training preferentially in human type 2 muscle fibres

The Journal of Physiology, EarlyView.
Abstract figure legend Sprint interval training (SIT) is a popular time‐efficient type of endurance training. Healthy young men performed nine SIT sessions (4–6 × 30 s all‐out cycling sprints) over 3 weeks while being supplemented with antioxidants (high doses of vitamins C and E) or placebo. Muscle biopsies taken before and after the first SIT session
Victoria L. Wyckelsma, Marta Murgia, Sigitas Kamandulis, Stefano Gastaldello, Marius Brazaitis, Audrius Snieckus, Nerijus Eimantas, Mati Pääsuke, Sebastian Edman, William Apro, Daniel C. Andersson, Håkan Westerblad, Tomas Venckunas   +12 more
wiley   +1 more source

A novel monoclonal antibody for detection of galectin-9 in tissue sections: application to human tissues infected by oncogenic viruses

Infectious Agents and Cancer, 2012
Background Galectin-9 is a mammalian lectin which possesses immunosuppressive properties. Excessive production of galectin-9 has been reported in two types of human virus-associated diseases chronic hepatitis C and nasopharyngeal carcinoma associated to ...
Barjon Clément, Niki Toshiro, Vérillaud Benjamin, Opolon Paule, Bedossa Pierre, Hirashima Mitsuomi, Blanchin Stéphanie, Wassef Michel, Rosen Hugo R, Jimenez Anne-Sophie, Wei Ming, Busson Pierre   +11 more
doaj   +1 more source

Retinoic acids inhibit activation-induced apoptosis in T cell hybridomas and thymocytes.

Journal of Immunology, 1992
Apoptosis is induced in immature thymocytes and T cell hybridomas upon stimulation via the TCR/CD3 complex. This phenomenon appears to be related to negative selection of T cell clones in the thymus.
M. Iwata, M. Mukai, Y. Nakai, R. Iseki
semanticscholar   +1 more source

Antitumor efficacy of intermittent low‐dose erlotinib plus sulindac via MHC upregulation and remodeling of the immune cell niche

International Journal of Cancer, Volume 157, Issue 2, Page 355-370, 15 July 2025.
What's new? Novel immunomodulatory insights derived from experimental models and clinical samples reveal the cancer‐preventive potential of intermittent low‐dose erlotinib plus sulindac (ERL + SUL). This study shows that ERL + SUL treatment upregulates MHC class I and II expression and remodels the immune cell niche, with significant tumor suppression ...
Chakrapani Tripathi, Jorge E. Tovar Perez, Sabeeta Kapoor, Ahmed Muhsin, Wan Mohaiza Dashwood, Yunus Demirhan, Melek Demirhan, Alessandro Shapiro, Altaf Mohammed, Shizuko Sei, Jacklyn Thompson, Mahira Zaheer, Krishna M. Sinha, Powel H. Brown, Michelle I. Savage, Eduardo Vilar, Praveen Rajendran, Roderick H. Dashwood   +17 more
wiley   +1 more source