Results 131 to 140 of about 45,417 (262)

Screening individual hybridomas by microengraving to discover monoclonal antibodies

open access: yesNature Protocols, 2009
A. Ogunniyi   +4 more
semanticscholar   +1 more source

Flow Cytometry: Advances, Challenges and Trends

open access: yesBioEssays, Volume 48, Issue 1, January 2026.
Recent advances in flow cytometry span hardware, data processing, and AI‐driven analytics. Emerging modalitiesincluding spectral, imaging, mass, and nano/EV cytometryenable higher‐parameter and small‐particle detection. Integrated machine learning drives a shift from manual gating toward automated multi‐omics workflows.
J. Paul Robinson   +2 more
wiley   +1 more source

Lysosomal processing of sulfatide analogs alters target NKT cell specificity and immune responses in cancer

open access: yesThe Journal of Clinical Investigation
In a structure-function study of sulfatides that typically stimulate type II NKT cells, we made an unexpected discovery. We compared analogs with sphingosine or phytosphingosine chains and 24-carbon acyl chains with 0-1-2 double bonds (C or pC24:0, 24:1,
Kumiko Nishio   +16 more
doaj   +1 more source

Nitration of GlcCer and Related Complex Lipids Enhances CD1d Binding Affinity and Modulates Immune Responses via Lipid Antigen Presentation to Natural Killer T Cells

open access: yesChemistryEurope, Volume 4, Issue 1, January 2026.
Nitration of glycolipids and phospholipids increases their binding to CD1d. Nitrated β‐GlcCer and phospholipids show strong CD1d binding but induce minimal cytokine production, suggesting potential immune suppression. In contrast, nitrated endogenous‐type α‐GalCer enhances cytokine responses, indicating that nitrated lipids can modulate CD1d‐mediated ...
Kodai Sueyoshi   +5 more
wiley   +1 more source

Antigen-specific identification and cloning of hybridomas with a fluorescence-activated cell sorter.

open access: yesProceedings of the National Academy of Sciences of the United States of America, 1979
D. Parks   +3 more
semanticscholar   +1 more source

Searching for Novel Antiviral Agents as COVID19 Treatments: Guanidino Diaryl Thioureas

open access: yesChemMedChem, Volume 21, Issue 1, January 2026.
Structure of the "hit‐compound" found and the proposed interaction with the active site of the TMPRSS2 protease, involving a reversible mechanism of action, are shown. The COVID‐19 pandemic highlighted the urgent need for effective antiviral treatments targeting SARS‐CoV‐2.
Marco Minneci   +6 more
wiley   +1 more source

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