Class-switched anti-insulin antibodies originate from unconventional antigen presentation in multiple lymphoid sites [PDF]
, 2016 Autoantibodies to insulin are a harbinger of autoimmunity in type 1 diabetes in humans and in non-obese diabetic mice. To understand the genesis of these autoantibodies, we investigated the interactions of insulin-specific T and B lymphocytes using T ...
Acevedo-Suárez +59 more
core +2 more sources
Development and characterization of novel chimeric monoclonal antibodies for broad spectrum neutralization of rabies virus. [PDF]
PLoS ONE, 2017 Current post-exposure prophylaxis for rabies virus infection has several limitations in terms of supply, cost, safety, and efficacy. Attempts to replace human or equine rabies immune globulins (HRIG or ERIG) have been made by several companies and ...
Pan Kyeom Kim +18 more
doaj +1 more source
Frontiers in Immunology, 2023 IntroductionSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), had a major impact on both the global health and economy.
Chang-Kyu Heo +9 more
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MANUFACTURING OF HYBRIDOMAS-PRODUCERS OF MONOCLONAL ANTIBODIES TO BRUCELLOSIS AGENT ANTIGENS
Проблемы особо опасных инфекций, 2017 Objective of study is to prepare hybridomas-producers of monoclonal antibodies to brucellosis agent antigens. Materials and methods. B. abortus, B. melitensis, B.
G. V. Kuklina +5 more
doaj +1 more source
Characterization and epitope mapping of human monoclonal antibodies to PDC-E2, the immunodominant autoantigen of primary biliary cirrhosis [PDF]
, 1992 Further to define the epitopes of PDC-E2, the major autoantigen in primary biliary cirrhosis (PBC), we have developed and characterized five human monoclonal antibodies. These antibodies were derived by fusing a regional hepatic lymph node from a patient
Bassendine +49 more
core +1 more source
Correlation between cell aggregation and antibody production in IgE-producing plasma cells
Biochemistry and Biophysics Reports, 2017 Allergic conditions result in the increase of immunoglobulin (Ig)E-producing plasma cells (IgE-PCs); however, it is unclear how IgE production is qualitatively controlled.
Mari Hikosaka +3 more
doaj +1 more source
Is cancer progression caused by gradual or simultaneous acquisitions of new chromosomes?
Molecular Cytogenetics, 2018 Background Foulds defined, “Tumor progression (as a) permanent, irreversible qualitative change in one or more of its characters” (Cancer Res. 1954).
Mathew Bloomfield, Peter Duesberg
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A New Workflow to Generate Monoclonal Antibodies against Microorganisms
Applied Sciences, 2021 Monoclonal antibodies are used worldwide as highly potent and efficient detection reagents for research and diagnostic applications. Nevertheless, the specific targeting of complex antigens such as whole microorganisms remains a challenge.
Markus Göthel +5 more
doaj +1 more source
Immunogenomic engineering of a plug-and-(dis)play hybridoma platform
Nature Communications, 2016 Hybridomas are widely used for antibody screening and production due to their genetic stability and rapid proliferation. Here the authors demonstrate the rapid reprogramming of antibody specificity in hybridomas using CRISPR-Cas9.
Mark Pogson +4 more
doaj +1 more source
Iranian Journal of Parasitology, 2022 Background: Leishmaniasis is a zoonotic disease, which is one of the serious public health problems in the world. Nowadays, antibody production using hybridoma technology may be a correct approach in terms of sensitivity in the diagnosis of diseases ...
Asli Pinar Zorba Yildiz +6 more
doaj +1 more source