Results 41 to 50 of about 4,421 (175)

Photochemical Deracemization of Chromanes and its Application to the Synthesis of Enantiopure Bioactive Compounds

open access: yesAngewandte Chemie, Volume 138, Issue 5, 28 January 2026.
Various substituted chromane‐2‐carboxamides were successfully deracemized by employing a chiral benzophenone (BP, 10 mol%) as photocatalyst and an achiral thiol as additive (20 mol%). The method was applied to the concise enantioselective synthesis of five active pharmaceutical ingredients.
Biki Ghosh   +5 more
wiley   +2 more sources

Theoretical calculation of the adiabatic electron affinity and vertical electron affinity of some hydantoin drugs

open access: yesJournal of Saudi Chemical Society, 2023
Several DFT approaches with 6–311 + G(2df,2p) basis set at the B3LYP/6–31 + G(d,p) geometries were examined to calculate accurate adiabatic electron affinity (AEA) for some hydantoin derivatives.
Nuha Wazzan, Zaki Safi
doaj   +1 more source

Marked Impact of Regulatory Bans on Formaldehyde and Formaldehyde‐Releaser‐Induced Allergic Contact Dermatitis: A Retrospective Cohort Study (1996–2024) From Turkey

open access: yesContact Dermatitis, EarlyView.
The overall prevalence of sensitization to FA/FRs was 1.9% (48/2592). ACD was diagnosed in 37.5% (18/48), comprising non‐occupational ACD (83.3%) and occupational ACD (16.7%). FA 1%–2% aq. failed to detect FR sensitisation in 31.9% (n = 15/47) and FR‐induced ACD in 35.3% (n = 6/17) of patients.
Esen Özkaya   +2 more
wiley   +1 more source

Synthesis, crystal structure and Hirshfeld surface analysis of 5,5-diphenyl-3-(prop-2-yn-1-yl)imidazolidine-2,4-dione

open access: yesActa Crystallographica Section E: Crystallographic Communications
The new phenytoin analogue 5,5-diphenyl-3-(2-propyn-1-yl)imidazolidine-2,4-dione, C18H14N2O2 (3), was obtained through an alkylation reaction with propargyl bromide via the phase-transfer catalysis method, and its structure was determined via single ...
Abderrazzak El Moutaouakil Ala Allah   +5 more
doaj   +1 more source

Computer-Aided Studies for Novel Arylhydantoin 1,3,5-Triazine Derivatives as 5-HT6 Serotonin Receptor Ligands with Antidepressive-Like, Anxiolytic and Antiobesity Action In Vivo

open access: yesMolecules, 2018
This study focuses on the design, synthesis, biological evaluation, and computer-aided structure-activity relationship (SAR) analysis for a novel group of aromatic triazine-methylpiperazines, with an hydantoin spacer between 1,3,5-traizine and the ...
Rafał Kurczab   +15 more
doaj   +1 more source

Effect of New 2-Thioxoimidazolidin-4-one Compounds against Staphylococcus aureus Clinical Strains and Immunological Markers’ Combinations

open access: yesCanadian Journal of Infectious Diseases and Medical Microbiology, 2022
Although the structure-activity relationship indicates that the 4-thioxoimidazolidin ring is essential for antibacterial activities and pharmaceutical applications, there were no enough studies on the derivatives of this compound.
Hanan Tariq Subhi   +2 more
doaj   +1 more source

ADAM17 and its proteolytic targets in disease pathogenesis

open access: yesThe FEBS Journal, EarlyView.
ADAM17 as a multifunctional sheddase with contrasting roles across inflammatory, metabolic, cardiovascular, and neoplastic diseases. Through regulated activation by iRhom, iTAP/FRMD8, and tetraspanins, ADAM17 cleaves diverse membrane ligands and receptors, thereby promoting inflammation, fibrosis, obesity, insulin resistance, and tumor progression ...
Abdulbasit Amin, Marina Badenes
wiley   +1 more source

The Aminobarbituric Acid−Hydantoin Rearrangement [PDF]

open access: yesThe Journal of Organic Chemistry, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
Manuela, Meusel   +3 more
openaire   +2 more sources

Continued Involvement: A Scoping Review on Family Members' Needs and Experiences Collaborating With Support Staff for Relatives With Intellectual Disabilities Living Outside the Family Home

open access: yesJournal of Intellectual Disability Research, EarlyView.
ABSTRACT Background Family members' involvement in the care for their relative often continues after their relative has moved out of the family home. However, little is known about the needs of family members when collaborating specifically with support staff caring for their relative.
Frances R. Vereijken   +3 more
wiley   +1 more source

Visible‐Light Mediated Functionalization in Phe‐Containing Peptides Upon a Debenzylative Amination Process

open access: yesAdvanced Synthesis &Catalysis, Volume 368, Issue 6, 17 March 2026.
Selective late‐stage modification of N‐terminal phenylalanine short peptides is achived by visible‐light initiated reaction with N‐iodoimides in a debenzylation–amination process. This metal‐free method permits the incorporation of N‐containing heterocycles into the α‐position of the peptide backbone.
Guillermo Morales‐Ortega   +4 more
wiley   +1 more source

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