Results 41 to 50 of about 3,489 (193)

New Roads Leading to Old Destinations: Efflux Pumps as Targets to Reverse Multidrug Resistance in Bacteria [PDF]

, 2017
Multidrug resistance (MDR) has appeared in response to selective pressures resulting from the incorrect use of antibiotics and other antimicrobials.
Amaral, Leonard, Gajdács, Márió, Kincses, Annamária, Spengler, Gabriella   +3 more
core   +8 more sources

Imide and isatin derivatives as β-lactam mimics of β-lactam antibiotics [PDF]

, 2002
Activated γ-lactams, which are derivatives of succinimide, phthalimide and isatin with suitable elements of molecular recognition, have been synthesised as mimics of the ß-lactam antibiotics and their chemical and biological reactivity ...
Casey, Lorraine A., Galt, Ronald H. B., Hadfield, Peter S., Page, Michael I., Vilanova, Bartholomew   +4 more
core   +1 more source

ヒスチジンタグを持つホスファカンコア蛋白の大腸菌での発現と精製 [PDF]

, 1999
Specific regions of core protein of phosphacan, one of the chondroitin sulfate proteoglycans, were expressed as fusion proteins with histidine-tag (His-tag) in Escherichia coli (E.coli) and were affinity purified using nickel-nitrilotriacetic acid (Ni ...
Ito, Sekiko, Mori, Shuji, Okamoto, Motoi
core   +1 more source

Photochemical Deracemization of Chromanes and its Application to the Synthesis of Enantiopure Bioactive Compounds

Angewandte Chemie, Volume 138, Issue 5, 28 January 2026.
Various substituted chromane‐2‐carboxamides were successfully deracemized by employing a chiral benzophenone (BP, 10 mol%) as photocatalyst and an achiral thiol as additive (20 mol%). The method was applied to the concise enantioselective synthesis of five active pharmaceutical ingredients.
Biki Ghosh, Maximilian Iglhaut, Daria Babushkina, Mike Pauls, Christoph Bannwarth, Thorsten Bach   +5 more
wiley   +2 more sources

Bifunctional Photocatalysts: Exploiting Proximity for Enhanced Reaction Performance

Chemistry – A European Journal, EarlyView.
This review covers the application of the bifunctional approach to photocatalysis as a means to attain (enhanced) enantioselectivity, and, more in general, as a strategy to enhance the catalytic performance through an effective use of short‐lived reaction intermediates.
Luigi Dolcini, Daniele Lavelli, Alberto Dal Corso, Luca Pignataro   +3 more
wiley   +1 more source

Complementary regioselectivity in the synthesis of iminohydantoins: remarkable effect of amide substitution on the cyclization [PDF]

, 2013
Complementary regioselective synthesis of iminohydantoins from isocyanoacetamides controlled by the substituent on the amide group has been described.
García Valverde, María, González Ortega, Alfonso ., Marcaccini, Stefano ., Rodríguez Vidal, Francisco Javier, Rojo Cámara, Mª Josefa, Torroba Pérez, Tomás   +5 more
core   +1 more source

Regioselective synthesis of 7,8-dihydroimidazo[5,1-c][1,2,4]triazine-3,6(2H,4H)-dione derivatives: A new drug-like heterocyclic scaffold

Beilstein Journal of Organic Chemistry, 2012
Dihydroimidazo[5,1-c][1,2,4]triazine-3,6(2H,4H)-dione derivatives were prepared by successive N3- and N1-alkylation of hydantoins, followed by regioselective thionation and subsequent cyclization under mild conditions.
Nikolay T. Tzvetkov, Harald Euler, Christa E. Müller   +2 more
doaj   +1 more source

Synthesis of New Imidazolidin-2,4-dione and 2-Thioxoimidazolidin-4-ones via C-Phenylglycine Derivatives

Molecules, 2009
Hydantoins and their derivatives constitute a group of pharmaceutical compounds with anticonvulsant and antiarrhythmic properties, and are also used against diabetes. N-3 and C-5 substituted imidazolidines are examples of such products.
José Alixandre de Sousa Luis, José Maria Barbosa Filho, Bruno Freitas Lira, Isac Almeida Medeiros, Liana Clébia Soares Lima de Morais, Alexsandro Fernandes dos Santos, Cledualdo Soares de Oliveira, Petrônio Filgueiras de Athayde-Filho   +7 more
doaj   +1 more source

Solid Shampoo Is Mostly Not Preserved, in Contrast to Liquid Shampoos Used in Hairdressing—A Market Survey in Four European Countries

Contact Dermatitis, EarlyView.
Most solid shampoos (68.6%) did not contain preservatives according to Annex V of the EU Cosmetics Regulation (EC 1223/2009), while all liquid shampoos did. The number of preservatives used was significantly greater in liquid shampoos. ABSTRACT Background Hairdressers are frequently exposed to shampoos, both from neat liquid products and dilutions ...
Wolfgang Uter, Anders B. Funch, Mikkel Bak Jensen, Christoffer Kursawe Larsen, Ying X. Teo, Jeanne D. Johansen, Carola Lidén, Ian R. White   +7 more
wiley   +1 more source

A Practical Approach to New (5Z) 2-Alkylthio-5-arylmethylene- 1-methyl-1,5-dihydro-4H-imidazol-4-one Derivatives [PDF]

, 2011
International audienceA practical protocol for the preparation of (5Z)-2-alkylthio-5-arylmethylene-1-methyl-1,5-dihydro-4H-imidazol-4-one derivatives is reported.
Bazureau, Jean-Pierre, Bourahla, Khadidja, Carreaux, François, Lozach, Olivier, Meijer, Laurent, Paquin, Ludovic   +5 more
core   +4 more sources