Results 81 to 90 of about 1,978 (203)
From Diketopiperazines to Hydantoins: An Unprecedented Rearrangement
, 2014 International audienceBis-Boc-activated 2,5-diketopiperazines on reaction with potassium hydroxide or sodium methoxide in dry tetrahydrofuran led to Boc-protected hydantoins through an unprecedented ring contraction.
Chaubet, Guilhem +4 more
core +1 more source
Microbial Biotechnology, Volume 19, Issue 3, March 2026.We engineered thermo‐alkali‐stable D‐hydantoinases via mutagenesis (M63A/F65H/C317T) to resolve Pregabalin's challenging chiral splitting, achieving ee value > 97% for key intermediate (R)‐3‐isobutylglutaric acid monoamide (R‐IBM) synthesis under extreme conditions (pH 10, 70°C–80°C).
Jiujiuzi Zhang +5 more
wiley +1 more source
Facile One-Pot Synthesis of Substituted Hydantoins from Carbamates
, 2017 A novel and simple approach for the preparation of 3-substituted, 5-substituted, or 3,5-disubstituted hydantoins is reported. It involves the reaction of α-amino methyl ester hydrochlorides with carbamates to yield the corresponding ureido derivatives ...
Anjali Ratan +2 more
core +1 more source
Contact Dermatitis, Volume 94, Issue 6, Page 689-693, June 2026.
Silada Kanokrungsee +6 more
wiley +1 more source
Contact Dermatitis, Volume 94, Issue 3, Page 272-285, March 2026.Allergic contact dermatitis is very common in patients with anogenital lesions referred for patch testing in Spain. Key allergens include fragrances, preservatives and topical treatments like anaesthetics and steroids. Emerging sensitisers including benzisothiazolinone and sodium metabisulphite are also relevant.
Mercè Grau‐Pérez +29 more
wiley +1 more source
Comparative metabolism of hydantoin and beta-methyl hydantoin.
Experimental Biology and Medicine, 1926 In previous experiments1 it was pointed out that when betamethyl hydantoin is given subcutaneously to dogs only fifteen per cent of the compound reappears unchanged in the urine. A similar amount is excreted as methyl hydantoic acid. But while all of the nitrogen of the compound was excreted, the remainder was unaccounted for in the nitrogen partition.
openaire +1 more source
Synthesis of substituted hydantoins in low melting mixtures [PDF]
, 2013 A novel domino synthesis of 1,3,5-trisubstituted hydantoin derivatives has been developed in low melting L-(+)-tartaricacid-DMU melt mixtures. The functionalized hydantoins are obtained in good yields from beta,gamma-unsaturated ketoacids and urea under ...
Chinthapally, Kiran +3 more
core +1 more source
Acute generalized exanthematous pustulosis related to phenytoin administration. Case report
Case Reports, 2016 The occurrence of acute generalized exanthematous pustulosis adverse reactions to medication administration is becoming more frequent. This article reports the case of a 78-year-old woman who attended the clinic with generalized papules and pustules on ...
Juan Raul Castro-Ayarza, Eduardo Fierro
doaj
Selective reductions of substituted hydantoins
, 1983 Nine N-3-substituted hydantoins (2) have been shown to undergo LiAlH4 reduction (tetrahydrofuran, room temperature, 2d) to give 4-hydroxy-2-imidazolidinones (21) in good yields.
Alvarado, Sergio Javier Cortes, 1950-
core
Facile one-pot synthesis of 5-substituted hydantoins.
, 2008 5-Substituted and 5,5-disubstituted hydantoins are synthesised from the corresponding aldehydes or ketones, using a one-pot, gallium(III) triflate-catalysed procedure that is compatible with a range of substrates and ...
Le Strat, F +8 more
core +1 more source