Results 81 to 90 of about 2,171 (198)

Probing 5‐Nitroimidazole‐Triazole Hybrids as Potential Anti‐Kinetoplastid Agents: Synthesis and In Vitro Efficacy

ChemMedChem, Volume 21, Issue 13, 14 July 2026.
A series of 5‐nitroimidazole‐1,2,3‐triazole hybrids was synthesised and evaluated for antitrypanosomatid activity to assess their potential as treatments against leishmaniasis and trypanosomiasis. No notable in vitro activity against Leishmania was detected.
Liandi Ferreira, Gideon D. Badenhorst, Janine Aucamp, Keisuke Suganuma, David D. N’Da   +4 more
wiley   +1 more source

Preparation of Hydantoins by Catalytic Oxidative Carbonylation of α-Amino Amides

, 2016
Hydantoins can be synthesized from the corresponding amino amides employing oxidative catalytic carbonylation using W(CO)6 as the catalyst, I2 as the oxidant, CO as the carbonyl source, and DBU as base.
Lisa McElwee-White (1453750), Delmy J. Díaz (2336692), Seth M. Dumbris (2254165)   +2 more
core   +1 more source

Acute generalized exanthematous pustulosis related to phenytoin administration. Case report

Case Reports, 2016
The occurrence of acute generalized exanthematous pustulosis adverse reactions to medication administration is becoming more frequent. This article reports the case of a 78-year-old woman who attended the clinic with generalized papules and pustules on ...
Juan Raul Castro-Ayarza, Eduardo Fierro
doaj  

A comparative study of the cis and trans isomers of two hydantoin compounds with anticonvulsant potency

Current Research in Biotechnology
Hydantoins are a class of compounds renowned for their diverse medical applications, particularly in neurology. Phenytoin (Dilantin) is one of the most well-known hydantoins, primarily used to stabilize neuronal membranes and prevent the spread of ...
Jana Tchekalarova, Tsveta Stoyanova, Petar Todorov   +2 more
doaj   +1 more source

Selective reductions of substituted hydantoins

, 1983
Nine N-3-substituted hydantoins (2) have been shown to undergo LiAlH4 reduction (tetrahydrofuran, room temperature, 2d) to give 4-hydroxy-2-imidazolidinones (21) in good yields.
Alvarado, Sergio Javier Cortes, 1950-
core  

Mechanochemical Preparation of Hydantoins from Amino Esters: Application to the Synthesis of the Antiepileptic Drug Phenytoin

, 2014
International audienceThe eco-friendly preparation of 5- and 5,5-disubstituted hydantoins from various amino ester hydrochlorides and potassium cyanate in a planetary ball-mill is described.
Colacino, Evelina, Lamaty, Frédéric, Konnert, Laure, Martinez, Jean, Reneaud, Benjamin, Campagne, Jean-Marc, Marcia de Figueiredo, Renata   +6 more
core   +1 more source

New route for 1-substituted hydantoins [PDF]

, 2022
Alkytation reactions on hydantoins (I) lead smoothly to 3-alkyl derivatives; more rigorous conditions allow further substitution at position 1 provided the N1-H group is activated by an aryl group or an ethylenic bond attached to the adjacent C52,a.
Corral, Renée Antonio, Orazi, Orfeo Osvaldo   +1 more
core  

Efflux pump blockers in Gram-negative bacteria:The new generation of hydantoin based-modulators to improve antibiotic activity

Frontiers in Microbiology, 2016
Multidrug resistant (MDR) bacteria are an increasing health problem with the shortage of new active antibiotic agents. Among effective mechanisms that contribute to the spread of MDR Gram-negative bacteria are drug efflux pumps that expel clinically ...
Ewa eOtrębska-Machaj, Ewa eOtrębska-Machaj, Jacqueline eChevalier, Jadwiga eHandzlik, Ewa eSzymańska, Jakub eSchabikowski, Gérard eBoyer, Jean-Michel eBolla, Katarzyna eKieć-Kononowicz, Jean-Marie ePAGES, Sandrine eAlibert   +10 more
doaj   +1 more source

From Diketopiperazines to Hydantoins: An Unprecedented Rearrangement

, 2014
International audienceBis-Boc-activated 2,5-diketopiperazines on reaction with potassium hydroxide or sodium methoxide in dry tetrahydrofuran led to Boc-protected hydantoins through an unprecedented ring contraction.
Chaubet, Guilhem, Lebrun, Aurélien, Parrot, Isabelle, Cazals, Guillaume, Martinez, Jean   +4 more
core   +1 more source

Solvent effects on the structure-property relationship of anticonvulsant hydantoin derivatives: A solvatochromic analysis

Chemistry Central Journal, 2011
Considering the pharmaceutical importance of hydantoins, a set of 25 derivatives of phenytoin, nirvanol and 5-methyl-5-phenylhydantoin, the lipophilicities of which were gradually increased by the introduction of different alkyl, cycloalkyl and alkenyl ...
Trišović Nemanja, Valentić Nataša, Ušćumlić Gordana   +2 more
doaj   +1 more source