Results 71 to 80 of about 3,541 (213)

Synthesis of Peptides, Peptide Nucleic Acid Components, and Other Biogenic Compounds From a Three‐Component Prebiotic Mixture

Chemistry – A European Journal, Volume 32, Issue 9, 2 March 2026.
High‐energy proton irradiation of a formamide–diaminomaleonitrile–glycine system in the presence of meteorites produces a broad spectrum of biogenic compounds, including nucleobases, nucleosides, peptides, and nucleobase–peptide conjugates, highlighting a chemically plausible prebiotic network.
Bruno Mattia Bizzarri, Rosangela Santalucia, Eleonora Mancin, Mikhail Kapralov, Eugene Krasavin, Raffaele Saladino, Ernesto Di Mauro   +6 more
wiley   +1 more source

Drug interaction in the emergency service [PDF]

, 2013
OBJECTIVE: To identify the occurrence of potential drug interactions in prescriptions for adult patients admitted to the Emergency Department of Hospital São Paulo. METHODS: A cross-sectional and descriptive study.
Batista, Ruth Ester Assayag, Cintra, Raíssa Silveira, Okuno, Meiry Fernanda Pinto, Vancini-campanharo, Cássia Regina   +3 more
core   +1 more source

Thermotolerant D‐Hydantoinases for Efficient and Stereoselective Intermediate Synthesis of (R)‐3‐Isobutylglutaric Acid Monoamide, a Key Intermediate in Pregabalin Production

Microbial Biotechnology, Volume 19, Issue 3, March 2026.
We engineered thermo‐alkali‐stable D‐hydantoinases via mutagenesis (M63A/F65H/C317T) to resolve Pregabalin's challenging chiral splitting, achieving ee value > 97% for key intermediate (R)‐3‐isobutylglutaric acid monoamide (R‐IBM) synthesis under extreme conditions (pH 10, 70°C–80°C).
Jiujiuzi Zhang, Bin Zhi, Zhenyu Xie, Beibei Zhang, Ning Wang, Wanpeng Wang   +5 more
wiley   +1 more source

Anogenital Contact Dermatitis in Spain: A REIDAC Study of Patients Undergoing Patch Testing in 2019–2024

Contact Dermatitis, Volume 94, Issue 3, Page 272-285, March 2026.
Allergic contact dermatitis is very common in patients with anogenital lesions referred for patch testing in Spain. Key allergens include fragrances, preservatives and topical treatments like anaesthetics and steroids. Emerging sensitisers including benzisothiazolinone and sodium metabisulphite are also relevant.
Mercè Grau‐Pérez, Pedro Mercader‐García, Ana María Giménez‐Arnau, Tatiana Sanz‐Sánchez, Violeta Zaragoza Ninet, Susana Córdoba Guijarro, Francisco Javier Miquel Miquel, Juan Francisco Silvestre Salvador, Ricardo González‐Pérez, Inmaculada Ruíz González, Esther Serra Baldrich, José Manuel Carrascosa, Francisco Javier Ortiz de Frutos, Mercedes Rodríguez Serna, María Elena Gatica Ortega, Carmen Paredes Suárez, Francisco José Navarro Triviño, Pablo Chicharro, Marta Andreu, Araceli Sánchez Gilo, José Juan Pereyra Rodríguez, María Antonia Pastor Nieto, Gemma Melé‐Ninot, Paloma Sánchez‐Pedreño Guillén, Enrique Gómez de la Fuente, Marta Elosua‐González, Mónica Munera‐Campos, Fátima Tous Romero, Miguel Ángel Descalzo, Leopoldo Borrego   +29 more
wiley   +1 more source

Synthesis of 5-bromonaphthalimide derivatives with 3-aminocycloalkanespiro-5-hydantoins [PDF]

BIO Web of Conferences
The present work reports a study on the interaction of 5-bromo-1H,3H-naphtho[1,8-cd]pyran-1,3-dione with various 3-aminocycloalkanespiro-5-hydantoins, aimed at the development of new biologically active compounds.
Marinov Marin, Nikolova Iliana, Kostova Iliana   +2 more
doaj   +1 more source

Prevalence of Contact Sensitisation Among Patients With Atopic Dermatitis in Thailand: A 20‐Year Retrospective Study

Contact Dermatitis, Volume 94, Issue 6, Page 689-693, June 2026.
Silada Kanokrungsee, Rungsima Kiratiwongwan, Nicha Wareesawetsuwan, Sasitorn Yenyuwadee, Pichanee Chaweekulrat, Titinun Kumpangsin, Waranya Boonchai   +6 more
wiley   +1 more source

Highly Substituted 1,4‐Benzodiazepin‐2‐ones: A Rapid Modular Approach From Arynes and Unsymmetrical Imides

ChemistryEurope, Volume 4, Issue 2, February 2026.
In this work, 1,4‐benzodiazepine‐2‐ones are synthesized starting from Kobayashi‐type aryne precursors and amino acid‐derived, unsymmetrical imides. Operationally simple protocols to access both the starting materials and the potential active pharmaceutical ingredients are presented.
Jasper Mindner, Julia Gartzke, Silas Wittmer, Tassilo Segerer, Burkhard Butschke, Daniel B. Werz   +5 more
wiley   +1 more source

Aryl hydantoin Ro 13-3978, a broad-spectrum antischistosomal [PDF]

, 2017
Objectives Praziquantel is the only drug available for the treatment of schistosomiasis and the state of the exhausted drug discovery pipeline is alarming.
Dong, Yuxiang, Gautam, Nagsen, Keiser, Jennifer, Panic, Gordana, Vargas, Mireille, Vennerstrom, Jonathan L., Wang, Chunkai   +6 more
core  

Xanthines as a scaffold for molecular diversity [PDF]

, 2018
Summary: Xanthines represent a new, versatile scaffold for combinatorial chemistry. A five-step solid-phase synthesis of xanthine derivatives is described which includes alkylations, a nucleophilic displacement reaction at a heterocycle and a ring ...
Eberle, Alex, Heizmann, Gerhard
core  

Ring closure reactions of bicyclic prolinol and prolin ester enantiomers [PDF]

, 2009
Starting from the of bicyclic proline ester, ethyl exo-2-azabicyclo[2.2.1]heptane-3-carboxylate (+)-5 several hydantoines and thiohydantoines were prepared by acidic ring closure of the corresponding urea or thiourea derivatives. Enantiomer (-)-5 was
Fülöp, Ferenc, Kivela, H., Molnar, Zs., Palkó, Márta, Pihlaja, K., Sinnkonen, J.   +5 more
core   +1 more source