Hydrazides as Powerful Tools in Medicinal Chemistry: Synthesis, Reactivity, and Biological Applications [PDF]
MoleculesThe increase in drug resistance and the high toxicity of current drugs have inspired the scientific community to develop new drugs for various diseases. Hydrazides have become an attractive functional group to easily obtain a plethora of novel compounds ...
Sofia Teixeira +2 more
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Design, Synthesis and Antitubercular Activity of Certain Nicotinic Acid Hydrazides
Molecules, 2015 Three series of 6-aryl-2-methylnicotinohydrazides 4a–i, N′-arylidene-6-(4-bromophenyl)-2-methylnicotino hydrazides 7a–f, and N′-(un/substituted 2-oxoindolin-3-ylidene)-6-(4-fluorophenyl)-2-methylnicotinohydrazides 8a–c were synthesized and evaluated for ...
Marwa M Abdel-Aziz +2 more
exaly +3 more sources
Palladium-catalyzed sulfonylative coupling of benzyl(allyl) carbonates with arylsulfonyl hydrazides
Green Synthesis and Catalysis, 2022 An efficient palladium-catalyzed sulfonylative coupling for the synthesis of benzyl(allyl) sulfones from sulfonyl hydrazides and carbonates was developed.
Haibo Zhu, Qiangwen Fan
exaly +3 more sources
Synthesis and characterization of FeCuAlO4 as a reusable heterogeneous acidic nanocatalyst for preparation of 2-amino-1,3,4-thiadiazole derivatives in water [PDF]
Scientific Reports2-amino-1,3,4-thiadiazole derivatives possess notable significance across therapeutic, agricultural, and industrial domains. The reaction of acid hydrazides and potassium thiocyanate in aqueous solution leads to the production of thiosemicarbazide ...
Abbas Nikoo
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Late-stage diversification strategy for the synthesis of peptide acids and amides using hydrazides [PDF]
Exploration of Drug Science, 2023 Aim: Modification of the C-terminus of a peptide to improve its properties, particularly after constructing the peptide chain, has great promise in the development of peptide therapeutics.
Shoko Tanaka +5 more
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Journal of Applied Pharmaceutical Research, 2022 Acid hydrazides are essential intermediates in organic synthesis. They conventionally require a two-step synthetic pathway; esterification and hydrazine hydrate treatment; to obtain the hydrazide. The microwave-assisted synthetic methodology was utilized
Sabah Mohamad +2 more
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Electrochemical Synthesis of Dibenzothiophene S,S-Dioxides from Biaryl Sulfonyl Hydrazides
Electrochemistry, 2023 The electrochemical synthesis of dibenzothiophene S,S-dioxides was achieved by the anodic oxidation of biaryl sulfonyl hydrazides. The use of Bu4NOTf as the electrolyte in HFIP/CH3NO2 (15 : 1) is essential.
Yasuyuki OKUMURA +3 more
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Synthesis of Some Substituted 1,3,4-Oxadiazoles, Thiadiazoles and 1,2,4-Triazoles from Acid Chlorides [PDF]
مجلة التربية والعلم, 2013 The conversion of some acid chlorides to substituted 1,3,4-oxadiazole, 1,3,4-thiadiazoles and 1,2,4-triazoles is reported. Benzoyl chloride and 4- nitrobenzoyl chloride were treated with hydrazine hydrate in ethanol to give acid hydrazides (1,2), The ...
E. Q. Mahmood, O. Th. Ali, K. M. Daoud
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Molecules, 2021 Based on the broad spectrum of biological activity of hydrazide–hydrazones, trifluoromethyl compounds, and clinical usage of cholinesterase inhibitors, we investigated hydrazones obtained from 4-(trifluoromethyl)benzohydrazide and various benzaldehydes ...
Martin Krátký +4 more
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Synthesis, Characterization and Antimicrobial Activity of Some New Tetrazole Derivatives from Hydrazones [PDF]
Iranian Journal of Chemistry & Chemical Engineering, 2022 In this investigation, a combination of Z1-Z5 hydrazone compounds is obtained from the reaction between 4-methylbenzohydrazide and aryl-aldehydes. A subsequent unique synthetic approach to the preparation of di-substituted tetrazoles T6-T10 was achieved ...
Ahmed Sajjad, Zainab Al Shuhaib
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