Results 21 to 30 of about 9,447 (241)

Исследование связи "структура - противомикробная активность" с использованием молекулярного докинга в ряду замещенных амидов и гидразидов n-ароил-5-бром (5-хлор) антраниловых кислот [PDF]

, 2018
Изучение связи "структура - противомикробная активность" в отношении кишечной палочки (E. Coli) с использованием молекулярного докинга в ряду замещенных амидов и гидразидов N-ароил 5-бром (5-хлор) антраниловых ...
Андрюков, К. В., Коркодинова, Л. М.   +1 more
core   +2 more sources

N-Alkyl-2-[4-(trifluoromethyl)benzoyl]hydrazine-1-carboxamides and Their Analogues: Synthesis and Multitarget Biological Activity

Molecules, 2020
Based on the isosterism concept, we have designed and synthesized homologous N-alkyl-2-[4-(trifluoromethyl)benzoyl]hydrazine-1-carboxamides (from C1 to C18) as potential antimicrobial agents and enzyme inhibitors.
Martin Krátký, Zsuzsa Baranyai, Šárka Štěpánková, Katarína Svrčková, Markéta Švarcová, Jiřina Stolaříková, Lilla Horváth, Szilvia Bősze, Jarmila Vinšová   +8 more
doaj   +1 more source

Hydrazides in the reaction with hydroxypyrrolines: less nucleophilicity – more diversity

Beilstein Journal of Organic Chemistry, 2021
Expedient protocols for the synthesis of three types of highly functionalized azaheterocyclic scaffolds (dihydropyridazines, tetrahydropyridazines, and partially saturated tricyclic systems) from readily available hydroxypyrrolines and hydrazides are ...
Dmitrii A. Shabalin, Evgeniya E. Ivanova, Igor A. Ushakov, Elena Yu. Schmidt, Boris A. Trofimov   +4 more
doaj   +1 more source

Different Schiff Bases—Structure, Importance and Classification

Molecules, 2022
Schiff bases are a vast group of compounds characterized by the presence of a double bond linking carbon and nitrogen atoms, the versatility of which is generated in the many ways to combine a variety of alkyl or aryl substituents. Compounds of this type
Edyta Raczuk, Barbara Dmochowska, Justyna Samaszko-Fiertek, Janusz Madaj   +3 more
doaj   +1 more source

Readily accessible sp3-rich cyclic hydrazine frameworks exploiting nitrogen fluxionality [PDF]

, 2020
Increased molecular complexity correlates with improved chances of success in the drug development process. Here, a strategy for the creation of sp3-rich, non-planar heterocyclic scaffolds suitable for drug discovery is described that obviates the need ...
Carson, Nessa, Clarkson, Guy J., Dean, Conor, Jones, Matthew L., Rajkumar, Sundaram, Roesner, Stefan, Shipman, Michael, Wills, Martin   +7 more
core   +1 more source

Síntese e caracterização de um novo complexo de platina (IV) a partir de seu análogo de platina (II) utilizando iodo molecular como agente oxidante: uma rota sintética interessante para obtenção de novos complexos de platina Synthesis and characterization of a novel platinum (IV) complex from its platinum (II) analogue using molecular iodine as an oxidizing agent: an interesting synthetic route for the preparation of new platinum complexes

Química Nova, 2007
In an attempt to reduce toxicity and widen the spectrum of activity of cisplatin and its analogues, much attention has been focused on designing new platinum complexes.
Wendell Guerra, Heveline Silva, Mauro Vieira de Almeida, Ana Paula Soares Fontes   +3 more
doaj   +1 more source

A facile, one-pot procedure for the conversion of aromatic aldehydes to esters, as well as thioesters and amides, via acyl hydrazide intermediates [PDF]

, 2015
In the present work, an effective and facile one-pot dealloying strategy has been developed to synthesize monolithic asymmetry-patterned nanoporous copper ribbons (AP-NPCRs) from melt-spun bi-phase Al 32 at% Cu alloy with trace α-Al.
Akhbar, AR, Baggs, H, Chudasama, V, Lee, MTW, Maruani, A, Richards, DA, Shamsabadi, A, Watkins, G   +7 more
core   +1 more source

Study on the synthesis of novel 5-substituted 2-[2-(pyridyl)ethenyl]-1,3,4-oxadiazoles and their acid–base interactions [PDF]

, 2014
: A series of novel 5-substituted 2-[2-(pyridyl)ethenyl]-1,3,4-oxadiazoles were efficiently synthesized by cyclocondensation of the appropriate 3-(pyridyl)acrylohydrazides with triethyl orthoesters in the presence of glacial acetic acid.
Agnieszka Kudelko, Karolina Jasiak, Krzysztof Ejsmont   +2 more
core   +1 more source

Synthesis and Quantitative Structure–Activity Relationship of Imidazotetrazine Prodrugs with Activity Independent of O6-Methylguanine-DNA-methyltransferase, DNA Mismatch Repair and p53. [PDF]

, 2013
The antitumor prodrug Temozolomide is compromised by its dependence for activity on DNA mismatch repair (MMR) and the repair of the chemosensitive DNA lesion, O6-methylguanine (O6-MeG), by O6-methylguanine-DNA-methyltransferase (EC 2.1.1.63, MGMT). Tumor
Arris C. E., Arrowsmith J., Barvaux V. A., Boberg F., Boyd M. R., Bunz F., Damera K., Darkes M. J. M., De K., Denny B. J., Dimitrios Pletsas, Dinca E. B., Elrashied A. E. Garelnabi, Garelnabi E. A. E., Hirose Y., Honnalli S. S., Judson P. L., Karran P., Karran P., Kotera M., Leteurtre F., Li Li, Liu L., McElhinney R. S., McGarrity J. F., Mladek A. C., Nishizuka S., Pletsas D., Richard T. Wheelhouse, Roger M. Phillips, Sarkaria J. N., Schmidt B. F., Schmiedekamp A., Shealy Y. F., Siddiqui A. A., Smith R. H., Stevens M. F. G., Svilar D., Wang Y., Wheelhouse R. T., Wheelhouse R. T., Zhang J., Zhang J.   +42 more
core   +1 more source

1,3-Dipolar cycloadditions of azomethine imines [PDF]

, 2015
Azomethine imines are considered 1,3-dipoles of the aza-allyl type which are transient intermediates and should be generated in situ but can also be stable and isolable compounds.
Nájera, Carmen, Sansano, Jose M., Yus, Miguel   +2 more
core   +3 more sources