Results 11 to 20 of about 3,055 (201)

Synthetic Strategies for Activity-Based Probes to Decode Ubiquitin-Like Modifiers. [PDF]

Chemistry
ABSTRACT Ubiquitin‐like proteins (Ubls) such as SUMO, NEDD8, ISG15, URM1, UFM1, FAT10, ATG8/ATG12, and FUBI are essential regulators of cellular homeostasis, controlling processes from protein stability and trafficking to immune signaling and autophagy.
Chanda S, Pham A, Karnati S, Rodriguez NS, Toner A, Liu WR.   +5 more
europepmc   +2 more sources

Synthesis of Some Substituted 1,3,4-Oxadiazoles, Thiadiazoles and 1,2,4-Triazoles from Acid Chlorides [PDF]

مجلة التربية والعلم, 2013
The conversion of some acid chlorides to substituted 1,3,4-oxadiazole, 1,3,4-thiadiazoles and 1,2,4-triazoles is reported. Benzoyl chloride and 4- nitrobenzoyl chloride were treated with hydrazine hydrate in ethanol to give acid hydrazides (1,2), The ...
E. Q. Mahmood, O. Th. Ali, K. M. Daoud
doaj   +1 more source

A Chitosan Hydrochloride Mediated, Simple and Efficient Approach for the Synthesis of Hydrazones, their in vitro Antimycobacterial Evaluations, and Molecular Modeling Studies (Part III)

SynOpen, 2023
A simple, eco-friendly and straightforward synthesis of hydrazones has been devised that is conducted in the presence of chitosan Hydrochloride (chitosan·HCl) as catalyst in aqueous-ethanol medium at room temperature.
Suraj N. Mali, Anima Pandey, Bapu Thorat
doaj   +1 more source

2-([1,2,4]triazolo[1,5-c]quinazoline-2-yl-)alkyl-(alkaryl-,aryl-)-amines and their derivatives. Message 2. The synthesis of (3Н-quinazoline-4-ylidene)hydrazides N-protected aminoacids, using a variety of amine-protecting approaches. Physical-chemical prop

Zaporožskij Medicinskij Žurnal, 2018
The synthetic potential of (3H-quinazoline-4-ylidene)hydrazides of carboxylic acids is significant in the context of new s-triazoloquinazolines creation and the obtained data of biological activity is a valid reason for the development of new methods of ...
Yu. V. Martynenko, M. S. Kazunin, I. S. Nosulenko, G. G. Berest, S. І. Kоvalenko, O. M. Kamyshnyi, N. M. Polishchuk   +6 more
doaj   +1 more source

Palladium-catalyzed sulfonylative coupling of benzyl(allyl) carbonates with arylsulfonyl hydrazides

Green Synthesis and Catalysis, 2022
An efficient palladium-catalyzed sulfonylative coupling for the synthesis of benzyl(allyl) sulfones from sulfonyl hydrazides and carbonates was developed.
Bozhen Gong, Haibo Zhu, Yishuai Liu, Qian Li, Liu Yang, Guorong Wu, Qiangwen Fan, Zongbo Xie, Zhanggao Le   +8 more
doaj   +1 more source

Síntese e caracterização de um novo complexo de platina (IV) a partir de seu análogo de platina (II) utilizando iodo molecular como agente oxidante: uma rota sintética interessante para obtenção de novos complexos de platina Synthesis and characterization of a novel platinum (IV) complex from its platinum (II) analogue using molecular iodine as an oxidizing agent: an interesting synthetic route for the preparation of new platinum complexes

Química Nova, 2007
In an attempt to reduce toxicity and widen the spectrum of activity of cisplatin and its analogues, much attention has been focused on designing new platinum complexes.
Wendell Guerra, Heveline Silva, Mauro Vieira de Almeida, Ana Paula Soares Fontes   +3 more
doaj   +1 more source

On the Nature of the Rotational Energy Barrier of Atropisomeric Hydrazides

Molecules, 2023
N-N atropisomers represent a useful class of compounds that has recently received important attention from many research groups. This article presents an in-depth analysis of the energy barrier needed for the racemization process of atropoisomeric ...
Andrea Pellegrini, Laura Marcon, Paolo Righi, Giovanni Centonze, Chiara Portolani, Marco Capodiferro, Shilashi Badasa Oljira, Simone Manetto, Alessia Ciogli, Giorgio Bencivenni   +9 more
doaj   +1 more source

Synthesis and Antibacterial Activity of New Azole, Diazole and Triazole Derivatives Based on p-Aminobenzoic Acid

Molecules, 2021
The p-aminobenzoic acid was applied for the synthesis of substituted 1-phenyl-5-oxopyrrolidine derivatives containing benzimidazole, azole, oxadiazole, triazole, dihydrazone, and dithiosemicarbazide moieties in the structure.
Birutė Sapijanskaitė-Banevič, Vykintas Palskys, Rita Vaickelionienė, Jūratė Šiugždaitė, Povilas Kavaliauskas, Birutė Grybaitė, Vytautas Mickevičius   +6 more
doaj   +1 more source

N-Alkyl-2-[4-(trifluoromethyl)benzoyl]hydrazine-1-carboxamides and Their Analogues: Synthesis and Multitarget Biological Activity

Molecules, 2020
Based on the isosterism concept, we have designed and synthesized homologous N-alkyl-2-[4-(trifluoromethyl)benzoyl]hydrazine-1-carboxamides (from C1 to C18) as potential antimicrobial agents and enzyme inhibitors.
Martin Krátký, Zsuzsa Baranyai, Šárka Štěpánková, Katarína Svrčková, Markéta Švarcová, Jiřina Stolaříková, Lilla Horváth, Szilvia Bősze, Jarmila Vinšová   +8 more
doaj   +1 more source

Hydrazides in the reaction with hydroxypyrrolines: less nucleophilicity – more diversity

Beilstein Journal of Organic Chemistry, 2021
Expedient protocols for the synthesis of three types of highly functionalized azaheterocyclic scaffolds (dihydropyridazines, tetrahydropyridazines, and partially saturated tricyclic systems) from readily available hydroxypyrrolines and hydrazides are ...
Dmitrii A. Shabalin, Evgeniya E. Ivanova, Igor A. Ushakov, Elena Yu. Schmidt, Boris A. Trofimov   +4 more
doaj   +1 more source